Role of connexin-43 in protective PI3K-Akt-GSK-3β signaling in cardiomyocytes

scientific article

Role of connexin-43 in protective PI3K-Akt-GSK-3β signaling in cardiomyocytes is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1152/AJPHEART.00940.2011
P698PubMed publication ID22505645

P2093author name stringAtsushi Kuno
Daisuke Sunaga
Hidemichi Kouzu
Masaya Tanno
Satoko Ishikawa
Takahito Itoh
Takayuki Miki
Tatsuya Sato
Tetsuji Miura
Hiromichi Murase
P2860cites workCardiac regulation by phosphoinositide 3-kinases and PTENQ24317248
Gating properties of heterotypic gap junction channels formed of connexins 40, 43, and 45.Q24675707
Activator of G protein signaling 8 (AGS8) is required for hypoxia-induced apoptosis of cardiomyocytes: role of G betagamma and connexin 43 (CX43)Q28513014
Modulation of intercellular communication in macrophages: possible interactions between GAP junctions and P2 receptorsQ28590048
p84, a new Gbetagamma-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110gammaQ28590777
3'Phosphoinositide-dependent kinase-1 is essential for ischemic preconditioning of the myocardium.Q33262306
Connexin43 knockdown or overexpression modulates cell coupling in control and failing rabbit left ventricular myocytesQ33814794
Electrophysiological remodeling in heart failureQ33887264
Mitochondrial kinase signalling pathways in myocardial protection from ischaemia/reperfusion-induced necrosisQ34620765
Residual Cx45 and its relationship to Cx43 in murine ventricular myocardiumQ35693797
Gap junctions and connexin-interacting proteinsQ35749955
Interaction of cardiovascular risk factors with myocardial ischemia/reperfusion injury, preconditioning, and postconditioning.Q37019662
Connexin-related signaling in cell death: to live or let die?Q37386613
Connexin43 phosphorylation: structural changes and biological effectsQ37421795
GSK-3beta, a therapeutic target for cardiomyocyte protectionQ37511449
Role of the gap junction in ischemic preconditioning in the heartQ37684629
Ser9 phosphorylation of mitochondrial GSK-3beta is a primary mechanism of cardiomyocyte protection by erythropoietin against oxidant-induced apoptosisQ39937560
Connexin 43 acts as a cytoprotective mediator of signal transduction by stimulating mitochondrial KATP channels in mouse cardiomyocytes.Q40238713
Activation of Akt is essential for acetylcholine to trigger generation of oxygen free radicals.Q40659920
Acetylcholine leads to free radical production dependent on K(ATP) channels, G(i) proteins, phosphatidylinositol 3-kinase and tyrosine kinaseQ40713421
Gap junctional communication underpins EDHF-type relaxations evoked by ACh in the rat hepatic arteryQ40805683
Ultrastructure and regulation of lateralized connexin43 in the failing heart.Q41912488
Modulation of astrocyte P2Y1 receptors by the carboxyl terminal domain of the gap junction protein Cx43.Q42159344
Phosphorylation of glycogen synthase kinase-3beta during preconditioning through a phosphatidylinositol-3-kinase--dependent pathway is cardioprotectiveQ43909380
Opioid-induced cardioprotection occurs via glycogen synthase kinase beta inhibition during reperfusion in intact rat heartsQ44344567
Bradykinin induces mitochondrial ROS generation via NO, cGMP, PKG, and mitoKATP channel opening and leads to cardioprotectionQ44575126
Gbetagammas and the Ras binding domain of p110gamma are both important regulators of PI(3)Kgamma signalling in neutrophilsQ45345833
Connexin43 in cardiomyocyte mitochondria contributes to mitochondrial potassium uptake.Q46001765
Presence of connexin 43 in subsarcolemmal, but not in interfibrillar cardiomyocyte mitochondria.Q46109567
Ischaemic post-conditioning protects both adult and aged Sprague-Dawley rat heart from ischaemia-reperfusion injury through the phosphatidylinositol 3-kinase-AKT and glycogen synthase kinase-3beta pathwaysQ46126389
Impairment of diazoxide-induced formation of reactive oxygen species and loss of cardioprotection in connexin 43 deficient miceQ46650190
Bradykinin prevents reperfusion injury by targeting mitochondrial permeability transition pore through glycogen synthase kinase 3betaQ46975352
Downregulation of connexin 45 gene products during mouse heart development.Q52176241
Heterogeneous Connexin43 distribution in heart failure is associated with dispersed conduction and enhanced susceptibility to ventricular arrhythmiasQ54952185
Mitochondrial connexin43 as a new player in the pathophysiology of myocardial ischaemia-reperfusion injury.Q55045700
P433issue12
P304page(s)H2536-44
P577publication date2012-04-13
P1433published inAmerican Journal of Physiology Heart and Circulatory PhysiologyQ3193662
P1476titleRole of connexin-43 in protective PI3K-Akt-GSK-3β signaling in cardiomyocytes
P478volume302

Reverse relations

cites work (P2860)
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Q92617115Therapeutic Potential of Oxytocin in Atherosclerotic Cardiovascular Disease: Mechanisms and Signaling Pathways
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