Rab GTPases and their interacting protein partners: Structural insights into Rab functional diversity

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Rab GTPases and their interacting protein partners: Structural insights into Rab functional diversity is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1080/21541248.2017.1336191
P932PMC publication ID5902227
P698PubMed publication ID28632484

P50authorAnne Houdusse-JuilléQ15845472
Olena PylypenkoQ41904835
Hussein HammichQ125267436
P2093author name stringI-Mei Yu
P2860cites workA structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1Q24294988
A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transportQ24295585
Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia diseaseQ24295739
GOLPH3 is essential for contractile ring formation and Rab11 localization to the cleavage site during cytokinesis in Drosophila melanogaster.Q35160845
Rab proteins and the compartmentalization of the endosomal systemQ35548944
Recruitment of OCRL and Inpp5B to phagosomes by Rab5 and APPL1 depletes phosphoinositides and attenuates Akt signalingQ35642868
Melanophilin Stimulates Myosin-5a Motor Function by Allosterically Inhibiting the Interaction between the Head and Tail of Myosin-5aQ35679335
The cargo-binding domain regulates structure and activity of myosin 5Q35752269
Rabenosyn-5 defines the fate of the transferrin receptor following clathrin-mediated endocytosisQ35779085
Legionella pneumophila LidA affects nucleotide binding and activity of the host GTPase Rab1Q35806017
Interaction analysis of prenylated Rab GTPase with Rab escort protein and GDP dissociation inhibitor explains the need for both regulatorsQ35927898
Targeting Rab GTPases to distinct membrane compartmentsQ35936418
Differential regulation of actin microfilaments by human MICAL proteinsQ36010015
An inducible mouse model for microvillus inclusion disease reveals a role for myosin Vb in apical and basolateral traffickingQ36155098
Cargo-selective apical exocytosis in epithelial cells is conducted by Myo5B, Slp4a, Vamp7, and Syntaxin 3.Q36266151
Review series: Rab GTPases and membrane identity: causal or inconsequential?Q37034278
Coordinated recruitment of Spir actin nucleators and myosin V motors to Rab11 vesicle membranesQ37253275
Griscelli syndrome: a model system to study vesicular traffickingQ37401438
Kinetic analysis of the guanine nucleotide exchange activity of TRAPP, a multimeric Ypt1p exchange factorQ37405222
The role of the hypervariable C-terminal domain in Rab GTPases membrane targeting.Q37599802
AMPylation is critical for Rab1 localization to vacuoles containing Legionella pneumophila.Q37631519
Apical trafficking in epithelial cells: signals, clusters and motorsQ37634760
Structurally distinct bacterial TBC-like GAPs link Arf GTPase to Rab1 inactivation to counteract host defensesQ24297790
Structure of the extremely slow GTPase Rab6A in the GTP bound form at 1.8A resolutionQ24298194
Membrane targeting and activation of the Lowe syndrome protein OCRL1 by rab GTPasesQ24299544
Crystal structure of rab11 in complex with rab11 family interacting protein 2Q24299686
Structural basis for Rab GTPase activation by VPS9 domain exchange factorsQ24303645
Structural basis of Rab5-Rabaptin5 interaction in endocytosisQ24304419
Structural basis for Rab11-mediated recruitment of FIP3 to recycling endosomesQ24305088
Structural basis for Rab11-dependent membrane recruitment of a family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1Q24306419
Nucleotide exchange via local protein unfolding--structure of Rab8 in complex with MSS4.Q24307945
Structural basis of family-wide Rab GTPase recognition by rabenosyn-5Q24309272
Rab and Arl GTPase family members cooperate in the localization of the golgin GCC185.Q24310137
RabGEFs are a major determinant for specific Rab membrane targetingQ24314408
Structural basis for recruitment of Rab6-interacting protein 1 to Golgi via a RUN domainQ24316267
Large nucleotide-dependent conformational change in Rab28Q24316429
Structural insights into the dual nucleotide exchange and GDI displacement activity of SidM/DrrAQ24321974
Identification and characterization of multiple novel Rab-myosin Va interactionsQ24322633
The FIP3-Rab11 protein complex regulates recycling endosome targeting to the cleavage furrow during late cytokinesis.Q24322791
Elucidation of Rab27 recruitment by its effectors: structure of Rab27a bound to Exophilin4/Slp2-aQ24336538
Structural basis for recruitment of RILP by small GTPase Rab7Q24529126
Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylationQ24647933
TIP47 is a key effector for Rab9 localizationQ24683616
Cellular functions of Rab GTPases at a glanceQ26798421
Molecular complexes that direct rhodopsin transport to primary ciliaQ26860718
The cellular and physiological functions of the Lowe syndrome protein OCRL1Q26862286
Bacterial pathogens commandeer Rab GTPases to establish intracellular nichesQ27026776
Head-to-tail regulation is critical for the in vivo function of myosin V.Q27310663
Rab35 GTPase couples cell division with initiation of epithelial apico-basal polarity and lumen openingQ27321208
Structural insights and in vitro reconstitution of membrane targeting and activation of human PI4KB by the ACBD3 proteinQ27325539
Structural basis of activation and GTP hydrolysis in Rab proteinsQ27617834
Crystal structures of a Rab protein in its inactive and active conformationsQ27628708
Structural plasticity of an invariant hydrophobic triad in the switch regions of Rab GTPases is a determinant of effector recognitionQ27630885
Structural basis of Rab effector specificity: crystal structure of the small G protein Rab3A complexed with the effector domain of rabphilin-3AQ27639792
Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferaseQ27640630
A Catalytic Coiled Coil: Structural Insights into the Activation of the Rab GTPase Sec4p by Sec2pQ27643770
Structure of the small GTPase Rab27b shows an unexpected swapped dimerQ27646174
The Structural Basis for Activation of the Rab Ypt1p by the TRAPP Membrane-Tethering ComplexesQ27650964
Structural basis for the exclusive specificity of Slac2-a/melanophilin for the Rab27 GTPasesQ27652590
RabGDI displacement by DrrA from Legionella is a consequence of its guanine nucleotide exchange activityQ27658919
Structural mechanism of host Rab1 activation by the bifunctional Legionella type IV effector SidM/DrrAQ27660007
Structural basis for Rab GTPase recognition and endosome tethering by the C2H2 zinc finger of Early Endosomal Autoantigen 1 (EEA1)Q27662147
The Legionella effector protein DrrA AMPylates the membrane traffic regulator Rab1bQ27663583
Protein LidA from Legionella is a Rab GTPase supereffectorQ27675125
The activation cycle of Rab GTPase Ypt32 reveals structural determinants of effector recruitment and GDI bindingQ27675208
Insights regarding guanine nucleotide exchange from the structure of a DENN-domain protein complexed with its Rab GTPase substrateQ27675441
Catalytic mechanism of a mammalian Rab⋅RabGAP complex in atomic detailQ27675470
Mechanism of Rab1b deactivation by the Legionella pneumophila GAP LepBQ27675735
Structural analyses of Legionella LepB reveal a new GAP fold that catalytically mimics eukaryotic RasGAPQ27677378
Structural Insights into a Unique Legionella pneumophila Effector LidA Recognizing Both GDP and GTP Bound Rab1 in Their Active StateQ27678042
Structural basis of cargo recognitions for class V myosinsQ27678783
The Legionella pneumophila GTPase Activating Protein LepB Accelerates Rab1 Deactivation by a Non-canonical Hydrolytic MechanismQ27678890
Intermediates in the Guanine Nucleotide Exchange Reaction of Rab8 Protein Catalyzed by Guanine Nucleotide Exchange Factors Rabin8 and GRABQ27680081
Structural basis of myosin V Rab GTPase-dependent cargo recognitionQ27680629
Structures of PI4KIII  complexes show simultaneous recruitment of Rab11 and its effectorsQ27684007
Molecular mechanism for Rabex-5 GEF activation by Rabaptin-5Q27684443
Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteinsQ27686798
Structure of Rab11-FIP3-Rabin8 reveals simultaneous binding of FIP3 and Rabin8 effectors to Rab11Q27701769
Coordination of Rab8 and Rab11 in primary ciliogenesisQ27967674
The roles of evolutionarily conserved functional modules in cilia-related traffickingQ28000150
BLOC-3 mutated in Hermansky-Pudlak syndrome is a Rab32/38 guanine nucleotide exchange factorQ28117259
The guanine nucleotide-binding switch in three dimensionsQ28131710
VipD is a Rab5-activated phospholipase A1 that protects Legionella pneumophila from endosomal fusion.Q37674312
Rab GEFs and GAPsQ37751479
Structure-function relationships of the G domain, a canonical switch motifQ37889983
Illuminating the functional and structural repertoire of human TBC/RABGAPs.Q37976530
Structural biology of Arf and Rab GTPases' effector recruitment and specificityQ38127799
Kinetics of interaction of Rab5 and Rab7 with nucleotides and magnesium ionsQ38353916
Structures of Ras superfamily effector complexes: What have we learnt in two decades?Q38399347
Rabaptin5 is recruited to endosomes by Rab4 and Rabex5 to regulate endosome maturationQ38830831
The lipid kinase PI4KIIIβ is highly expressed in breast tumors and activates Akt in cooperation with Rab11aQ38981564
Molecular control of Rab activity by GEFs, GAPs and GDI.Q39068332
Microvillus inclusion disease: loss of Myosin vb disrupts intracellular traffic and cell polarity.Q39076973
Multivalent Rab interactions determine tether-mediated membrane fusionQ39182367
Rab11-FIP3 links the Rab11 GTPase and cytoplasmic dynein to mediate transport to the endosomal-recycling compartmentQ39760408
ConSurf 2016: an improved methodology to estimate and visualize evolutionary conservation in macromoleculesQ39776544
Rab6 regulates transport and targeting of exocytotic carriersQ40097541
Multiple regions contribute to membrane targeting of Rab GTPasesQ40488536
Architecture and mechanism of the late endosomal Rab7-like Ypt7 guanine nucleotide exchange factor complex Mon1-Ccz1.Q40831502
Rab35 GTPase Triggers Switch-like Recruitment of the Lowe Syndrome Lipid Phosphatase OCRL on Newborn EndosomesQ40847509
bMERB domains are bivalent Rab8 family effectors evolved by gene duplicationQ41111601
Reversible phosphocholination of Rab proteins by Legionella pneumophila effector proteinsQ41898316
Diversity and plasticity in Rab GTPase nucleotide release mechanism has consequences for Rab activation and inactivationQ41940031
The motor function of Drosophila melanogaster myosin-5 is activated by calcium and cargo-binding protein dRab11.Q41998305
A molecular network for de novo generation of the apical surface and lumenQ42116509
Rab35 promotes the recruitment of Rab8, Rab13 and Rab36 to recycling endosomes through MICAL-L1 during neurite outgrowthQ42175750
A pull-down procedure for the identification of unknown GEFs for small GTPasesQ42730859
Structure of the disordered C terminus of Rab7 GTPase induced by binding to the Rab geranylgeranyl transferase catalytic complex reveals the mechanism of Rab prenylationQ42906968
Membrane targeting mechanism of Rab GTPases elucidated by semisynthetic protein probesQ45345750
Rab35 GTPase and OCRL phosphatase remodel lipids and F-actin for successful cytokinesis.Q45998530
Active diffusion positions the nucleus in mouse oocytesQ48583286
The mammalian Rab family of small GTPases: definition of family and subfamily sequence motifs suggests a mechanism for functional specificity in the Ras superfamily.Q48745906
Properties and catalytic activities of MICAL1, the flavoenzyme involved in cytoskeleton dynamics, and modulation by its CH, LIM and C-terminal domains.Q50335798
Rab GTPases containing a CAAX motif are processed post-geranylgeranylation by proteolysis and methylation.Q50336184
Biophysical Analysis of the Interaction of Rab6a GTPase with Its Effector DomainsQ57278410
GTPase activity of Rab5 acts as a timer for endocytic membrane fusionQ59097967
'Rab'ing up endosomal membrane transportQ77614150
Rab GTPases at a glanceQ81566767
Membrane Trafficking: An Endosome Tether Meets a Rab and CollapsesQ88623657
Rab GTPases as coordinators of vesicle trafficQ28131746
Rab5 regulates the kiss and run fusion between phagosomes and endosomes and the acquisition of phagosome leishmanicidal properties in RAW 264.7 macrophagesQ28138534
Evolution of the Rab family of small GTP-binding proteinsQ28204091
Phosphatidylinositol 4-kinasebeta is critical for functional association of rab11 with the Golgi complexQ28242748
Legionella pneumophila regulates the small GTPase Rab1 activity by reversible phosphorylcholinationQ28485632
Modulation of Rab GTPase function by a protein phosphocholine transferaseQ28485636
An actin-dependent mechanism for long-range vesicle transportQ28506739
The Arf and Rab11 effector FIP3 acts synergistically with ASAP1 to direct Rabin8 in ciliary receptor targetingQ28508183
cDNA cloning of component A of Rab geranylgeranyl transferase and demonstration of its role as a Rab escort proteinQ28569766
Crystal structure of the Rab binding domain of OCRL1 in complex with Rab8 and functional implications of the OCRL1/Rab8 module for Lowe syndromeQ29543937
Role of Rab GTPases in membrane traffic and cell physiologyQ29616548
Rabs and their effectors: achieving specificity in membrane trafficQ29619989
Structure of doubly prenylated Ypt1:GDI complex and the mechanism of GDI-mediated Rab recyclingQ30476697
Myosin Vb uncoupling from RAB8A and RAB11A elicits microvillus inclusion diseaseQ30581661
Rab11-FIP2 interaction with MYO5B regulates movement of Rab11a-containing recycling vesiclesQ30582688
A RAB5/RAB4 recycling circuitry induces a proteolytic invasive program and promotes tumor disseminationQ30584664
An endosomal tether undergoes an entropic collapse to bring vesicles togetherQ30831126
Oxidation of F-actin controls the terminal steps of cytokinesisQ30840206
Dual roles for the Drosophila PI 4-kinase four wheel drive in localizing Rab11 during cytokinesisQ33589995
Thousands of rab GTPases for the cell biologistQ34055251
Divalent Rab effectors regulate the sub-compartmental organization and sorting of early endosomes.Q34109207
Structural basis for the recruitment and activation of the Legionella phospholipase VipD by the host GTPase Rab5.Q34120152
Melanophilin directly links Rab27a and myosin Va through its distinct coiled-coil regionsQ34133114
Multiple factors contribute to inefficient prenylation of Rab27a in Rab prenylation diseasesQ34225670
Organization of the Rab-GDI/CHM superfamily: the functional basis for choroideremia diseaseQ34328378
Four additional members of the ras gene superfamily isolated by an oligonucleotide strategy: molecular cloning of YPT-related cDNAs from a rat brain libraryQ34368280
Untangling the evolution of Rab G proteins: implications of a comprehensive genomic analysisQ34370824
Toward a comprehensive map of the effectors of rab GTPasesQ34513353
TBC-domain GAPs for Rab GTPases accelerate GTP hydrolysis by a dual-finger mechanism.Q34549396
Rab GTPase prenylation hierarchy and its potential role in choroideremia diseaseQ35072549
P275copyright licenseCreative Commons Attribution-NonCommercial-NoDerivs 4.0 InternationalQ24082749
P433issue1-2
P921main subjectenzymeQ8047
peptideQ172847
transport proteinQ2111029
P304page(s)22-48
P577publication date2017-07-07
2018-03-04
P1433published inSmall GTPases (journal)Q15709529
P1476titleRab GTPases and their interacting protein partners: Structural insights into Rab functional diversity
P478volume9

Reverse relations

cites work (P2860)
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Q98171214Golgi inCOGnito: From vesicle tethering to human disease
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Q90179411Lcn2-derived Circular RNA (hsa_circ_0088732) Inhibits Cell Apoptosis and Promotes EMT in Glioma via the miR-661/RAB3D Axis
Q92763162Multiple Roles of Rab GTPases at the Golgi
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