Dyrk kinases regulate phosphorylation of doublecortin, cytoskeletal organization, and neuronal morphology

scientific article

Dyrk kinases regulate phosphorylation of doublecortin, cytoskeletal organization, and neuronal morphology is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/CM.21021
P932PMC publication ID3556588
P698PubMed publication ID22359282

P50authorJohn L. BixbyQ37374710
Vance P. LemmonQ37374728
P2093author name stringLindsey D Salay
Tatiana I Slepak
P2860cites workIsoform diversity and regulation in peripheral and central neurons revealed through RNA-SeqQ21134805
A high-resolution anatomical atlas of the transcriptome in the mouse embryoQ21145782
DYRK1A autophosphorylation on serine residue 520 modulates its kinase activity via 14-3-3 bindingQ24293338
Mirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1alphaQ24295673
DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damageQ24299608
Doublecortin microtubule affinity is regulated by a balance of kinase and phosphatase activity at the leading edge of migrating neuronsQ24306132
A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFATQ24306261
Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signalingQ24309408
A novel CNS gene required for neuronal migration and involved in X-linked subcortical laminar heterotopia and lissencephaly syndromeQ24314944
Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligaseQ24321736
ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damageQ24336416
Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivoQ24685647
The DCX-domain tandems of doublecortin and doublecortin-like kinaseQ27640972
Genetic analysis of anterior posterior expression gradients in the developing mammalian forebrainQ48345756
A phosphorylation cycle shapes gradients of the DYRK family kinase Pom1 at the plasma membrane.Q50622605
Doublecortin supports the development of dendritic arbors in primary hippocampal neurons.Q50654286
Disorganized microtubules underlie the formation of retraction bulbs and the failure of axonal regeneration.Q50668696
Structural and functional characteristics of Dyrk, a novel subfamily of protein kinases with dual specificity.Q51987577
The expression of the testis-specific Dyrk4 kinase is highly restricted to step 8 spermatids but is not required for male fertility in mice.Q51994844
The minibrain kinase homolog, mbk-2, is required for spindle positioning and asymmetric cell division in early C. elegans embryos.Q52095708
High-level expression of the Mnb/Dyrk1A gene in brain and heart during rat early development.Q52172241
MicroRNA-199b targets the nuclear kinase Dyrk1a in an auto-amplification loop promoting calcineurin/NFAT signalling.Q54631073
Doublecortin, a brain-specific gene mutated in human X-linked lissencephaly and double cortex syndrome, encodes a putative signaling proteinQ28263735
Genetic interactions between doublecortin and doublecortin-like kinase in neuronal migration and axon outgrowthQ28508775
Mice lacking doublecortin and doublecortin-like kinase 2 display altered hippocampal neuronal maturation and spontaneous seizuresQ28594825
Doublecortin associates with microtubules preferentially in regions of the axon displaying actin-rich protrusive structuresQ30273865
Spinophilin facilitates dephosphorylation of doublecortin by PP1 to mediate microtubule bundling at the axonal wrist.Q30479752
Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injuryQ30513561
DCX, a new mediator of the JNK pathwayQ30555002
Multisite phosphorylation of doublecortin by cyclin-dependent kinase 5.Q30760812
Identification of genes up-regulated by retinoic-acid-induced differentiation of the human neuronal precursor cell line NTERA-2 cl.D1.Q31832242
Cdk5 phosphorylation of doublecortin ser297 regulates its effect on neuronal migrationQ33197074
Activation-loop autophosphorylation is mediated by a novel transitional intermediate form of DYRKsQ33217276
A chemical screen identifies novel compounds that overcome glial-mediated inhibition of neuronal regeneration.Q33548229
The dynamic cytoskeleton: backbone of dendritic spine plasticityQ34441669
REST regulates DYRK1A transcription in a negative feedback loopQ34696021
Link between DYRK1A overexpression and several-fold enhancement of neurofibrillary degeneration with 3-repeat tau protein in Down syndromeQ34867587
Axon Guidance by Growth Cones and Branches: Common Cytoskeletal and Signaling MechanismsQ35568663
DCX's phosphorylation by not just another kinase (JNK).Q35760537
Pom1 DYRK regulates localization of the Rga4 GAP to ensure bipolar activation of Cdc42 in fission yeast.Q36514609
Evolutionary constraints associated with functional specificity of the CMGC protein kinases MAPK, CDK, GSK, SRPK, DYRK, and CK2alphaQ36519173
Molecular pathways regulating cytoskeletal organization and morphological changes in migrating neurons.Q37030402
Synaptic plasticity, neurogenesis, and functional recovery after spinal cord injuryQ37421067
DYRK family of protein kinases: evolutionary relationships, biochemical properties, and functional rolesQ37806870
MNB/DYRK1A as a multiple regulator of neuronal developmentQ37820722
High content screening of cortical neurons identifies novel regulators of axon growthQ41327476
Splice variants of the dual specificity tyrosine phosphorylation-regulated kinase 4 (DYRK4) differ in their subcellular localization and catalytic activityQ41767041
A JIP3-regulated GSK3β/DCX signaling pathway restricts axon branchingQ42065122
Kinase/phosphatase overexpression reveals pathways regulating hippocampal neuron morphology.Q42526841
Nonprimed and DYRK1A-primed GSK3 beta-phosphorylation sites on MAP1B regulate microtubule dynamics in growing axons.Q43102409
DYRK1A accumulates in splicing speckles through a novel targeting signal and induces speckle disassemblyQ44473703
Expression patterns and subcellular localization of the Down syndrome candidate protein MNB/DYRK1A suggest a role in late neuronal differentiation.Q44482754
Doublecortin maintains bipolar shape and nuclear translocation during migration in the adult forebrainQ46473576
JNK phosphorylates Ser332 of doublecortin and regulates its function in neurite extension and neuronal migrationQ48087566
Experimentally induced alteration in the polarity of developing neuronsQ48182875
A double-take on MAPsQ48325463
P433issue7
P921main subjectcytoskeletonQ154626
phosphorylationQ242736
P304page(s)514-527
P577publication date2012-03-07
P1433published inCytoskeletonQ2196987
P1476titleDyrk kinases regulate phosphorylation of doublecortin, cytoskeletal organization, and neuronal morphology
P478volume69

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cites work (P2860)
Q47823260CA1 pyramidal neuron gene expression mosaics in the Ts65Dn murine model of Down syndrome and Alzheimer's disease following maternal choline supplementation (MCS).
Q37633101Cortical Morphogenesis during Embryonic Development Is Regulated by miR-34c and miR-204.
Q28541616Design and synthesis of a library of lead-like 2,4-bisheterocyclic substituted thiophenes as selective Dyrk/Clk inhibitors
Q28539344Desvenlafaxine may accelerate neuronal maturation in the dentate gyri of adult male rats
Q48088472Dual-specificity tyrosine phosphorylation-regulated kinase 2 regulates osteoclast fusion in a cell heterotypic manner.
Q37633160Intracellular distribution of differentially phosphorylated dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A).
Q83225454Sequential phosphorylation of NDEL1 by the DYRK2-GSK3β complex is critical for neuronal morphogenesis
Q48100839Spag6 Negatively Regulates Neuronal Migration During Mouse Brain Development.
Q42213761Traffic jams and the complex role of α-Synuclein aggregation in Parkinson disease
Q35749574USP47 and C terminus of Hsp70-interacting protein (CHIP) antagonistically regulate katanin-p60-mediated axonal growth
Q36001639shRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act as Genetic Modifiers of Alpha-Synuclein Aggregation, Secretion and Toxicity

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