Pancreatic stellate cell secreted IL-6 stimulates STAT3 dependent invasiveness of pancreatic intraepithelial neoplasia and cancer cells

scientific article published on September 2016

Pancreatic stellate cell secreted IL-6 stimulates STAT3 dependent invasiveness of pancreatic intraepithelial neoplasia and cancer cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.18632/ONCOTARGET.11786
P932PMC publication ID5323208
P698PubMed publication ID27602757

P50authorNagaraj NagathihalliQ83375638
P2093author name stringYanhua Xiong
Nipun B Merchant
Jason A Castellanos
Michael N VanSaun
Xizi Dai
Qiaozhi Guo
Mahogany Ambrose
P2860cites workThe pancreatic stellate cell: a star on the rise in pancreatic diseasesQ24676727
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Interstitial fluid flow and drug delivery in vascularized tumors: a computational modelQ27310300
Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in miceQ29617045
S1PR1-STAT3 signaling is crucial for myeloid cell colonization at future metastatic sites.Q30514214
Pancreatic stellate cells promote hapto-migration of cancer cells through collagen I-mediated signalling pathwayQ30567121
Diagnostic and Prognostic Impact of Circulating YKL-40, IL-6, and CA 19.9 in Patients with Pancreatic CancerQ34806348
Combined blockade of Src kinase and epidermal growth factor receptor with gemcitabine overcomes STAT3-mediated resistance of inhibition of pancreatic tumor growthQ34812100
Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer.Q35740663
Comparative phenotypic studies of duct epithelial cell lines derived from normal human pancreas and pancreatic carcinomaQ35753107
Pancreatic cancer-associated stroma productionQ36168805
Pancreatic stellate cells: a starring role in normal and diseased pancreasQ36192959
Targeted Inhibition of Src Kinase Signaling Attenuates Pancreatic TumorigenesisQ36253834
Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment.Q36691086
Epidermal growth factor receptor regulates pancreatic fibrosisQ37337706
STAT3 as a central regulator of tumor metastasesQ37550770
Fibrogenesis in pancreatic cancer is a dynamic process regulated by macrophage-stellate cell interaction.Q37711618
The impact of the activated stroma on pancreatic ductal adenocarcinoma biology and therapy resistanceQ37978347
Interleukin-6 signaling pathway in targeted therapy for cancerQ38014987
Revisiting STAT3 signalling in cancer: new and unexpected biological functionsQ38262473
Novel mechanistic insights into ectodomain shedding of EGFR Ligands Amphiregulin and TGF-α: impact on gastrointestinal cancers driven by secondary bile acids.Q38615458
Proteome variations in pancreatic stellate cells upon stimulation with proinflammatory factorsQ39088558
STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis.Q39540918
Tumor-stromal interactions with direct cell contacts enhance proliferation of human pancreatic carcinoma cells.Q39802638
The RON receptor tyrosine kinase mediates oncogenic phenotypes in pancreatic cancer cells and is increasingly expressed during pancreatic cancer progression.Q40110348
Immortalization of pancreatic stellate cells as an in vitro model of pancreatic fibrosis: deactivation is induced by matrigel and N-acetylcysteineQ40380544
Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cellsQ40436319
Desmoplastic reaction in pancreatic cancer: role of pancreatic stellate cellsQ40515728
Tumor stroma interactions induce chemoresistance in pancreatic ductal carcinoma cells involving increased secretion and paracrine effects of nitric oxide and interleukin-1betaQ40588153
Tumor-stroma interaction of human pancreatic cancer: acquired resistance to anticancer drugs and proliferation regulation is dependent on extracellular matrix proteins.Q40601873
Cell lineage markers in human pancreatic cancerQ43550994
Understanding the stroma of pancreatic cancer: co-evolution of the microenvironment with epithelial carcinogenesisQ44165695
Activation of STAT3 by IL-6 and IL-10 in primary human macrophages is differentially modulated by suppressor of cytokine signaling 3.Q44355411
Elevated serum interleukin-6 levels in patients with pancreatic cancer.Q50904492
Pancreatitis and the risk of pancreatic cancer. International Pancreatitis Study Group.Q51056982
Stat3/Socs3 Activation by IL-6 Transsignaling Promotes Progression of Pancreatic Intraepithelial Neoplasia and Development of Pancreatic CancerQ60594558
Cytokines in pancreatic carcinoma: correlation with phenotypic characteristics and prognosisQ80962995
Dynamics of the immune reaction to pancreatic cancer from inception to invasionQ81381605
P4510describes a project that usesImageJQ1659584
P433issue40
P407language of work or nameEnglishQ1860
P921main subjectintraepithelial neoplasiaQ6058399
neoplastic invasivenessQ112498967
P304page(s)65982-65992
P577publication date2016-09-01
P1433published inOncotargetQ1573155
P1476titlePancreatic stellate cell secreted IL-6 stimulates STAT3 dependent invasiveness of pancreatic intraepithelial neoplasia and cancer cells
P478volume7

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