PI3K/AKT pathway regulates phosphorylation of steroid receptors, hormone independence and tumor differentiation in breast cancer

scientific article

PI3K/AKT pathway regulates phosphorylation of steroid receptors, hormone independence and tumor differentiation in breast cancer is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/CARCIN/BGR303
P698PubMed publication ID22180571
P5875ResearchGate publication ID51899102

P50authorClaudia LanariQ96097618
P2093author name stringMarina Riggio
Virginia Novaro
Matías Blaustein
Alejandro Colman-Lerner
Isabel Lüthy
María Laura Polo
P2860cites workThe MPA mouse breast cancer model: evidence for a role of progesterone receptors in breast cancer.Q37384523
Distinct biological roles for the akt family in mammary tumor progressionQ37737861
Akt isoforms regulate intermediate filament protein levels in epithelial carcinoma cellsQ39746827
Novel human breast cancer cell lines IBH-4, IBH-6, and IBH-7 growing in nude mice.Q39887248
Akt-induced endocrine therapy resistance is reversed by inhibition of mTOR signalingQ40095128
Activation of NF-kappaB by Akt upregulates Snail expression and induces epithelium mesenchyme transitionQ40120833
A transient three-plasmid expression system for the production of high titer retroviral vectorsQ40393091
Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinaseQ40533718
Three novel hormone-responsive cell lines derived from primary human breast carcinomas: functional characterization.Q40565025
Inhibition of mammary tumor growth by estrogens: is there a specific role for estrogen receptors alpha and beta?Q43220491
HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells.Q44450066
Activation of Akt-1 (PKB-alpha) can accelerate ErbB-2-mediated mammary tumorigenesis but suppresses tumor invasionQ44883122
Carcinoma-associated fibroblasts activate progesterone receptors and induce hormone independent mammary tumor growth: A role for the FGF-2/FGFR-2 axis.Q46394153
Progestins initiate a luminal to myoepithelial switch in estrogen-dependent human breast tumors without altering growthQ46788389
The association between Akt activation and resistance to hormone therapy in metastatic breast cancerQ46932769
Mice expressing myrAKT1 in the mammary gland develop carcinogen-induced ER-positive mammary tumors that mimic human breast cancerQ57975488
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complexQ24295120
Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylationQ24312168
Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTENQ24322051
Loss of Phosphatase and Tensin homologue deleted on chromosome 10 engages ErbB3 and insulin-like growth factor-I receptor signaling to promote antiestrogen resistance in breast cancerQ24653934
Akt kinases in breast cancer and the results of adjuvant therapyQ24795435
Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistanceQ28141690
Hormone dependence of a mouse mammary tumor line induced in vivo by medroxyprogesterone acetateQ28330193
Regulation of mammary stem/progenitor cells by PTEN/Akt/beta-catenin signalingQ28475546
In vitro propagation and transcriptional profiling of human mammary stem/progenitor cellsQ29616498
Three-dimensional culture models of normal and malignant breast epithelial cellsQ30496418
Proteomics exploration reveals that actin is a signaling target of the kinase Akt.Q33262841
Responsiveness to PI3K and MEK inhibitors in breast cancer. Use of a 3D culture system to study pathways related to hormone independence in miceQ33592917
Distinct roles of the three Akt isoforms in lactogenic differentiation and involutionQ33854404
Key signalling nodes in mammary gland development and cancer. Signalling downstream of PI3 kinase in mammary epithelium: a play in 3 AktsQ33889507
Akt/PKB regulates laminin and collagen IV isotypes of the basement membraneQ33951903
Hyperactivation of phosphatidylinositol-3 kinase promotes escape from hormone dependence in estrogen receptor-positive human breast cancerQ33968076
Emerging targeted therapies for breast cancerQ34119550
The role of genetic abnormalities of PTEN and the phosphatidylinositol 3-kinase pathway in breast and ovarian tumorigenesis, prognosis, and therapyQ34437249
Akt directly regulates focal adhesion kinase through association and serine phosphorylation: implication for pressure-induced colon cancer metastasisQ34717955
Tamoxifen resistance in breast tumors is driven by growth factor receptor signaling with repression of classic estrogen receptor genomic functionQ34745057
The PTEN-PI3K pathway: of feedbacks and cross-talksQ34828662
Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transitionQ36320600
Clinical significance of Akt and HER2/neu overexpression in African-American and Latina women with breast cancerQ36643018
Activation of AKT/PKB in breast cancer predicts a worse outcome among endocrine treated patientsQ36644036
Chromatin remodeling and control of cell proliferation by progestins via cross talk of progesterone receptor with the estrogen receptors and kinase signaling pathwaysQ36721725
Targeted therapies in breast cancer: where are we now?Q37327300
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
P304page(s)509-518
P577publication date2011-12-17
P1433published inCarcinogenesisQ326022
P1476titlePI3K/AKT pathway regulates phosphorylation of steroid receptors, hormone independence and tumor differentiation in breast cancer
P478volume33

Reverse relations

cites work (P2860)
Q37695410AKT1 and AKT2 isoforms play distinct roles during breast cancer progression through the regulation of specific downstream proteins
Q36355880Activation of PI3K/Akt/mTOR signaling in the tumor stroma drives endocrine therapy-dependent breast tumor regression
Q36769499Coactivators enable glucocorticoid receptor recruitment to fine-tune estrogen receptor transcriptional responses
Q42519337Comprehensive analysis of PTEN status in breast carcinomas
Q47694885Estrogen Receptors in Cell Membranes: Regulation and Signaling
Q54492986Fatty acid synthase regulates proliferation and migration of colorectal cancer cells via HER2-PI3K/Akt signaling pathway.
Q42645301In pulmonary lymphangioleiomyomatosis expression of progesterone receptor is frequently higher than that of estrogen receptor
Q36580396MicroRNA-374a activates Wnt/β-catenin signaling to promote breast cancer metastasis
Q33940350PIK3CA gene mutations and overexpression: implications for prognostic biomarker and therapeutic target in Chinese esophageal squamous cell carcinoma
Q37688583Relationship between tumour PTEN/Akt/COX-2 expression, inflammatory response and survival in patients with colorectal cancer.
Q55110307SIRT1 promotes formation of breast cancer through modulating Akt activity.
Q36165519The role of the PI3K/AKT signaling pathway in DADS-induced apoptosis of K562 cells
Q90559037Water-Soluble Nanoconjugate for Enhanced Cellular Delivery of Receptor-Targeted Magnetic Resonance Contrast Agents

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