Pharmacodynamic evaluation of irinotecan therapy by FDG and FLT PET/CT imaging in a colorectal cancer xenograft model

scientific article

Pharmacodynamic evaluation of irinotecan therapy by FDG and FLT PET/CT imaging in a colorectal cancer xenograft model is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S11307-011-0529-8
P8608Fatcat IDrelease_7gfi3xyqk5ht5jbfb234mhgdse
P698PubMed publication ID22167582

P2093author name stringCherrie K Donawho
Gerard B Fox
Mark Day
Arunava Chakravartty
Joann P Palma
Yanping Luo
Gail Bukofzer
Martin J Voorbach
Todd B Cole
David R Reuter
Sarah R Mudd
Paul Tapang
Kimberley D Holich
P2860cites workMolecular imaging in drug developmentQ22122025
Progress and promise of FDG-PET imaging for cancer patient management and oncologic drug developmentQ28245741
Next generation topoisomerase I inhibitors: Rationale and biomarker strategiesQ29011931
Regulation and functional contribution of thymidine kinase 1 in repair of DNA damageQ34094598
3'-deoxy-3'-[18F]fluorothymidine as a new marker for monitoring tumor response to antiproliferative therapy in vivo with positron emission tomography.Q34211088
A quantitative analysis of the kinetics of the G(2) DNA damage checkpoint systemQ35648439
[18F]FLT-PET in oncology: current status and opportunitiesQ35964138
Using imaging biomarkers to accelerate drug development and clinical trialsQ36039936
Positron emission tomography measurement of tumor metabolism and growth: its expanding role in oncologyQ36420719
Knockdown of the DNA repair and redox signaling protein Ape1/Ref-1 blocks ovarian cancer cell and tumor growthQ36468236
Imaging and oncologic drug development.Q36531381
Imaging of cell proliferation: status and prospectsQ37181529
Irinotecan therapy and molecular targets in colorectal cancer: a systemic reviewQ37571729
The histone deacetylase inhibitor PXD101 increases the efficacy of irinotecan in in vitro and in vivo colon cancer modelsQ38480031
Imaging colon cancer response following treatment with AZD1152: a preclinical analysis of [18F]fluoro-2-deoxyglucose and 3'-deoxy-3'-[18F]fluorothymidine imagingQ39606309
Early evaluation of the effects of chemotherapy with longitudinal FDG small-animal PET in human testicular cancer xenografts: early flare response does not reflect refractory disease.Q39909714
Noninvasive imaging of cell proliferation following mitogenic extracellular kinase inhibition by PD0325901.Q39939997
Colorectal tumor cells treated with 5-FU, oxaliplatin, irinotecan, and cetuximab exhibit changes in 18F-FDG incorporation corresponding to hexokinase activity and glucose transport.Q39960608
Irinotecan-induced apoptosis is inhibited by increased P-glycoprotein expression and decreased p53 in human hepatocellular carcinoma cellsQ40099977
Enhanced apoptotic reaction correlates with suppressed tumor glucose utilization after cytotoxic chemotherapy: use of 99mTc-Annexin V, 18F-FDG, and histologic evaluationQ40426552
Monitoring antiproliferative responses to kinase inhibitor therapy in mice with 3'-deoxy-3'-18F-fluorothymidine PET.Q40474923
Kinetics of 3'-deoxy-3'-18F-fluorothymidine during treatment monitoring of recurrent high-grade gliomaQ43097958
ABT-888 confers broad in vivo activity in combination with temozolomide in diverse tumorsQ43236659
Apoptosis and changes in glucose transport early after treatment of Morris hepatoma with gemcitabineQ43611315
Evaluation of pyrimidine metabolising enzymes and in vitro uptake of 3'-[(18)F]fluoro-3'-deoxythymidine ([(18)F]FLT) in pancreatic cancer cell lines.Q44112084
Validation of FLT uptake as a measure of thymidine kinase-1 activity in A549 carcinoma cells.Q44128080
Early changes in [18F]FLT uptake after chemotherapy: an experimental studyQ44192327
Predicting treatment response of malignant gliomas to bevacizumab and irinotecan by imaging proliferation with [18F] fluorothymidine positron emission tomography: a pilot studyQ46616816
PET/CT in the evaluation of response to treatment of liver metastases from colorectal cancer with bevacizumab and irinotecanQ46897347
In vivo biological activity of the histone deacetylase inhibitor LAQ824 is detectable with 3'-deoxy-3'-[18F]fluorothymidine positron emission tomography.Q53526226
Imaging proliferation in vivo with [F-18]FLT and positron emission tomography.Q54117465
Rapid rise in FDG uptake in an irradiated human tumour xenograft.Q55478609
Mitotic delay and repair in human lymphocytesQ71048640
Comparison of the pharmacokinetics and efficacy of irinotecan after administration by the intravenous versus intraperitoneal route in miceQ74756536
P433issue5
P921main subjectcolorectal cancerQ188874
irinotecanQ412197
pharmacodynamicsQ725307
colorectal carcinomaQ25493920
xenograftQ64148587
P304page(s)617-624
P577publication date2012-10-01
P1433published inMolecular Imaging and BiologyQ6895951
P1476titlePharmacodynamic evaluation of irinotecan therapy by FDG and FLT PET/CT imaging in a colorectal cancer xenograft model
P478volume14

Reverse relations

cites work (P2860)
Q37474422Combined Injection of (18)F-Fluorodeoxyglucose and 3'-Deoxy-3'-[(18)F]fluorothymidine PET Achieves More Complete Identification of Viable Lung Cancer Cells in Mice and Patients than Individual Radiopharmaceutical: A Proof-of-Concept Study
Q53110150Diagnostic performance of ¹⁸F-fluorothymidine PET/CT for primary colorectal cancer and its lymph node metastasis: comparison with ¹⁸F-fluorodeoxyglucose PET/CT.
Q39669240Evaluation of [18F]Fluorothymidine as a Biomarker for Early Therapy Response in a Mouse Model of Colorectal Cancer
Q33889809FLT-PET for early response evaluation of colorectal cancer patients with liver metastases: a prospective study
Q39018737HIV infection accelerates gastrointestinal tumor outgrowth in NSG-HuPBL mice
Q35081130Imaging of treatment response to the combination of carboplatin and paclitaxel in human ovarian cancer xenograft tumors in mice using FDG and FLT PET
Q36177290Longitudinal tumor hypoxia imaging with [(18)F]FAZA-PET provides early prediction of nanoliposomal irinotecan (nal-IRI) treatment activity
Q47103576Mismatched intratumoral distribution of [18F] fluorodeoxyglucose and 3'-deoxy-3'-[18F] fluorothymidine in patients with lung cancer
Q26778463Monitoring of anti-cancer treatment with (18)F-FDG and (18)F-FLT PET: a comprehensive review of pre-clinical studies
Q38775709Preclinical Applications of 3'-Deoxy-3'-[18F]Fluorothymidine in Oncology - A Systematic Review
Q36894808[18F]-FLT positron emission tomography can be used to image the response of sensitive tumors to PI3-kinase inhibition with the novel agent GDC-0941.

Search more.