Sorafenib inhibits neuroblastoma cell proliferation and signaling, blocks angiogenesis, and impairs tumor growth

scientific article

Sorafenib inhibits neuroblastoma cell proliferation and signaling, blocks angiogenesis, and impairs tumor growth is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/PBC.24004
P698PubMed publication ID22147414
P5875ResearchGate publication ID51858126

P50authorSusan L. CohnQ41883268
P2093author name stringMichael L Maitland
Yufeng Tian
Alexandre Chlenski
Helen R Salwen
Qiwei Yang
Lisa J Guerrero
Nisha C Kakodkar
Radhika R Peddinti
P2860cites workNeuroblastoma: biology, prognosis, and treatmentQ37683919
Thrombospondin-1 peptide ABT-510 combined with valproic acid is an effective antiangiogenesis strategy in neuroblastomaQ40169611
Sorafenib (BAY 43-9006) inhibits tumor growth and vascularization and induces tumor apoptosis and hypoxia in RCC xenograft modelsQ40198053
Proteomic analysis of neuroblastoma subtypes in response to mitogen-activated protein kinase inhibition: profiling multiple targets of cancer kinase signalingQ40285212
Multiple receptor tyrosine kinases regulate HIF-1alpha and HIF-2alpha in normoxia and hypoxia in neuroblastoma: implications for antiangiogenic mechanisms of multikinase inhibitorsQ43140228
Synergistic efficacy of sorafenib and genistein in growth inhibition by down regulating angiogenic and survival factors and increasing apoptosis through upregulation of p53 and p21 in malignant neuroblastoma cells having N-Myc amplification or non-aQ43272233
Neuroblastoma angiogenesis is inhibited with a folded synthetic molecule corresponding to the epidermal growth factor-like module of the follistatin domain of SPARC.Q45113187
NeuroblastomaQ54265665
Prominent Microvascular Proliferation in Clinically Aggressive NeuroblastomaQ57734254
Tumor angiogenesis: therapeutic implicationsQ27860595
Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signalingQ28296761
Anti-angiogenic SPARC peptides inhibit progression of neuroblastoma tumorsQ33955200
Tumor angiogenesis correlates with metastatic disease, N-myc amplification, and poor outcome in human neuroblastomaQ34733110
VEGF-targeted therapy: mechanisms of anti-tumour activity.Q34791610
The regulation of angiogenesis in neuroblastomaQ35184933
Signal transduction via the MAP kinases: proceed at your own RSK.Q36381460
Discovery and development of sorafenib: a multikinase inhibitor for treating cancer.Q36610990
Safety, pharmacokinetics, and preliminary antitumor activity of sorafenib: a review of four phase I trials in patients with advanced refractory solid tumorsQ36807146
Phase I trial and pharmacokinetic study of ixabepilone administered daily for 5 days in children and adolescents with refractory solid tumorsQ37104791
Initial testing (stage 1) of the multi-targeted kinase inhibitor sorafenib by the pediatric preclinical testing programQ37295112
P433issue4
P921main subjectneuroblastomaQ938205
P304page(s)642-647
P577publication date2011-12-06
P1433published inPediatric Blood & CancerQ15754342
P1476titleSorafenib inhibits neuroblastoma cell proliferation and signaling, blocks angiogenesis, and impairs tumor growth
P478volume59

Reverse relations

cites work (P2860)
Q35078100A mechanism linking Id2-TGFβ crosstalk to reversible adaptive plasticity in neuroblastoma
Q26771708Cell Proliferation in Neuroblastoma
Q38010377Development of treatment strategies for advanced neuroblastoma
Q50073387Emerging and investigational therapies for neuroblastoma.
Q38108399Emerging drugs for neuroblastoma
Q46314776Feasibility of HLA-haploidentical hematopoietic stem cell transplantation with post-transplantation cyclophosphamide for advanced pediatric malignancies
Q36916322HDAC inhibitors suppress c-Jun/Fra-1-mediated proliferation through transcriptionally downregulating MKK7 and Raf1 in neuroblastoma cells
Q36250783Molecular profiling of childhood cancer: Biomarkers and novel therapies
Q52639269Neuroblastoma: clinical and biological approach to risk stratification and treatment.
Q42736880Sorafenib treatment in children with relapsed and refractory neuroblastoma: an experience of four cases
Q52597787Too many targets, not enough patients: rethinking neuroblastoma clinical trials.
Q37259264Type III TGF-β receptor promotes FGF2-mediated neuronal differentiation in neuroblastoma

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