Comparative analysis of pre-replication complex proteins in transformed and normal cells

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Comparative analysis of pre-replication complex proteins in transformed and normal cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/JCB.24006
P698PubMed publication ID22134836

P2093author name stringMaria Zannis-Hadjopoulos
Domenic Di Paola
P2860cites workInhibition of eukaryotic DNA replication by geminin binding to Cdt1Q24290664
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A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replicationQ24647097
Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensingQ24647856
Replication fork velocities at adjacent replication origins are coordinately modified during DNA replication in human cellsQ24679451
PCNA acts as a stationary loading platform for transiently interacting Okazaki fragment maturation proteinsQ24811726
14-3-3 proteins function in the initiation and elongation steps of DNA replication in Saccharomyces cerevisiaeQ27929787
The 14-3-3 protein homologues from Saccharomyces cerevisiae, Bmh1p and Bmh2p, have cruciform DNA-binding activity and associate in vivo with ARS307.Q27932007
GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forksQ27934889
DNA replication in eukaryotic cellsQ28131747
Ku80 binds to human replication origins prior to the assembly of the ORC complexQ28252302
Cdc7 inhibition reveals a p53-dependent replication checkpoint that is defective in cancer cellsQ28286189
PCNA, the maestro of the replication forkQ28303101
Right place, right time, and only once: replication initiation in metazoansQ30438278
The spatio-temporal organization of DNA replication sites is identical in primary, immortalized and transformed mammalian cellsQ31112880
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Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress.Q40035632
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Overexpression of ORC subunits and increased ORC-chromatin association in transformed mammalian cellsQ40373347
Decreased origin usage and initiation of DNA replication in haploinsufficient HCT116 Ku80+/- cellsQ40398220
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DNA content and chromatin texture of benzo[a]pyrene-transformed human breast epithelial cells as assessed by image analysisQ41003102
Eucaryotic DNA: organization of the genome for replicationQ41891888
DNA replication regulation protein Mcm7 as a marker of proliferation in prostate cancerQ42150330
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Deregulated minichromosomal maintenance protein MCM7 contributes to oncogene driven tumorigenesisQ42491680
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Role of the beta isoform of 14-3-3 proteins in cellular proliferation and oncogenic transformationQ42834335
Cell type-specific responses of human cells to inhibition of replication licensingQ43219572
Is there a pre-RC checkpoint that cancer cells lack?Q46760534
Localization of MCM2-7, Cdc45, and GINS to the site of DNA unwinding during eukaryotic DNA replication.Q46949073
Identification and functional analysis of a human homologue of the monkey replication origin ors8.Q50724389
Dynamics of DNA replication in mammalian somatic cells: nucleotide pool modulates origin choice and interorigin spacing.Q51834619
Ku is involved in cell growth, DNA replication and G1-S transition.Q53500086
Identification of novel initiation sites for human DNA replication around ARSH1, a previously characterized yeast replicator.Q54735331
Control of DNA replication and its potential clinical exploitation.Q55039971
Chaotic license for genetic instability and cancerQ56928083
Deletion of the cruciform binding domain in CBP/14-3-3 displays reduced origin binding and initiation of DNA replication in budding yeastQ33281965
Reduction of Orc6 expression sensitizes human colon cancer cells to 5-fluorouracil and cisplatinQ33396223
Increased origin activity in transformed versus normal cells: identification of novel protein players involved in DNA replication and cellular transformationQ33523235
Hypermethylated 14-3-3-sigma and ESR1 gene promoters in serum as candidate biomarkers for the diagnosis and treatment efficacy of breast cancer metastasisQ33582678
14-3-3gamma induces oncogenic transformation by stimulating MAP kinase and PI3K signalingQ33632327
Temporal differences in DNA replication during the S phase using single fiber analysis of normal human fibroblasts and glioblastoma T98G cellsQ33693748
Association of human origin recognition complex 1 with chromatin DNA and nuclease-resistant nuclear structuresQ33890737
A p53-dependent checkpoint pathway prevents rereplicationQ34533175
Utilization of the same DNA replication origin by human cells of different derivationQ34608729
Human Cdc45 is a proliferation-associated antigen.Q34645501
The role of pre-replicative complex (pre-RC) components in oncogenesisQ34661644
Deregulated overexpression of hCdt1 and hCdc6 promotes malignant behaviorQ34714143
DNA end binding activity and Ku70/80 heterodimer expression in human colorectal tumorQ35165910
DNA replication origin interference increases the spacing between initiation events in human cellsQ35191023
Dynamics of pre-replication complex proteins during the cell division cycleQ35213825
A cancer-associated PCNA expressed in breast cancer has implications as a potential biomarker.Q35220061
An origin of DNA replication in the promoter region of the human fragile X mental retardation (FMR1) geneQ35642112
Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication.Q36752433
Cell cycle regulation of DNA replication.Q36881426
Differential DNA replication origin activities in human normal skin fibroblast and HeLa cell linesQ36889231
Analysis of re-replication from deregulated origin licensing by DNA fiber spreadingQ37041809
The human GINS complex associates with Cdc45 and MCM and is essential for DNA replicationQ37169802
DNA replication and the GINS complex: localization on extended chromatin fibersQ37202985
DNA replication in early S phase pauses near newly activated originsQ37233544
Divergent S phase checkpoint activation arising from prereplicative complex deficiency controls cell survivalQ37327314
Why are we where we are? Understanding replication origins and initiation sites in eukaryotes using ChIP-approaches.Q37630984
A human DNA replication origin: localization and transcriptional characterizationQ38331620
14-3-3sigma is a cruciform DNA binding protein and associates in vivo with origins of DNA replicationQ38362716
Overexpression of the replication licensing regulators hCdt1 and hCdc6 characterizes a subset of non-small-cell lung carcinomas: synergistic effect with mutant p53 on tumor growth and chromosomal instability--evidence of E2F-1 transcriptional controQ38782589
In vivo association of Ku with mammalian origins of DNA replicationQ39265275
Eukaryotic chromosome replicationQ39364965
Ku86 is important for TrkA overexpression-induced breast cancer cell invasionQ39623103
Minichromosome maintenance (MCM) protein 4 as a marker for proliferation and its clinical and clinicopathological significance in non-small cell lung cancerQ39649520
Quantitative protein expression profiling of 14-3-3 isoforms in human renal carcinoma shows 14-3-3 epsilon is involved in limitedly increasing renal cell proliferationQ39767003
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)1333-1347
P577publication date2012-04-01
P1433published inJournal of Cellular BiochemistryQ6294917
P1476titleComparative analysis of pre-replication complex proteins in transformed and normal cells
P478volume113

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cites work (P2860)
Q36538243Cancer cell response to anthracyclines effects: mysteries of the hidden proteins associated with these drugs
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Q34227699Cdc6 cooperates with c-Myc to promote genome instability and epithelial to mesenchymal transition EMT in zebrafish
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Q52322877The Human Replicative Helicase, the CMG Complex, as a Target for Anti-cancer Therapy.
Q41950020The prognostic significance of Cdc6 and Cdt1 in breast cancer

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