Preclinical antitumor activity of the novel heat shock protein 90 inhibitor CH5164840 against human epidermal growth factor receptor 2 (HER2)-overexpressing cancers

scientific article

Preclinical antitumor activity of the novel heat shock protein 90 inhibitor CH5164840 against human epidermal growth factor receptor 2 (HER2)-overexpressing cancers is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/J.1349-7006.2011.02144.X
P698PubMed publication ID22050138
P5875ResearchGate publication ID51767537

P2093author name stringNobuya Ishii
Shigeo Sato
Takaaki Miura
Ryoichi Saitoh
Toshihiko Fujii
Yuko Aoki
Toshikazu Yamazaki
Naomi Ono
Atsushi Suda
Osamu Kondoh
Takuo Tsukuda
Yukako Tachibana
Yoshito Nakanishi
Kihito Hada
Toshiyuki Mio
Kiyoaki Sakata
Kohnosuke Nakano
P2860cites workA combination of Trastuzumab and 17-AAG induces enhanced ubiquitinylation and lysosomal pathway-dependent ErbB2 degradation and cytotoxicity in ErbB2-overexpressing breast cancer cellsQ39943622
A central role for HER3 in HER2-amplified breast cancer: implications for targeted therapyQ39960692
High HSP90 expression is associated with decreased survival in breast cancerQ40149432
Activated B-RAF is an Hsp90 client protein that is targeted by the anticancer drug 17-allylamino-17-demethoxygeldanamycinQ40345142
Epidermal growth factor receptors harboring kinase domain mutations associate with the heat shock protein 90 chaperone and are destabilized following exposure to geldanamycinsQ40396742
Surface charge and hydrophobicity determine ErbB2 binding to the Hsp90 chaperone complex.Q40473008
A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitorsQ40631570
Polyubiquitination and proteasomal degradation of the p185c-erbB-2 receptor protein-tyrosine kinase induced by geldanamycinQ41168181
Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3Q24633878
The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferationQ24678674
Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug designQ27672398
The selective class I PI3K inhibitor CH5132799 targets human cancers harboring oncogenic PIK3CA mutationsQ27851644
Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogeneQ27860693
Targeting the dynamic HSP90 complex in cancerQ28288602
Drugging the cancer chaperone HSP90: combinatorial therapeutic exploitation of oncogene addiction and tumor stressQ28303213
HSP90 and the chaperoning of cancerQ29617504
Combination of trastuzumab and tanespimycin (17-AAG, KOS-953) is safe and active in trastuzumab-refractory HER-2 overexpressing breast cancer: a phase I dose-escalation studyQ33377626
Elevated expression of activated forms of Neu/ErbB-2 and ErbB-3 are involved in the induction of mammary tumors in transgenic mice: implications for human breast cancerQ33890758
Discovery and development of Hsp90 inhibitors: a promising pathway for cancer therapyQ34111364
V600E B-Raf requires the Hsp90 chaperone for stability and is degraded in response to Hsp90 inhibitorsQ34248395
AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activityQ34511038
Resiliency and vulnerability in the HER2-HER3 tumorigenic driverQ34551761
Update on Hsp90 inhibitors in clinical trial.Q35009729
Heat shock protein 90 as a molecular target for cancer therapeuticsQ35099516
Targeting Hsp90: small-molecule inhibitors and their clinical developmentQ37222845
Heat shock protein 90 as a drug target: some like it hot.Q37360814
Novel anticancer targets: revisiting ERBB2 and discovering ERBB3.Q37523202
Resistance to HER2 inhibitors: is addition better than substitution? Rationale for the hypothetical concept of drug sedimentationQ37777749
P433issue2
P921main subjectErb-b2 receptor tyrosine kinase 2Q415271
overexpressionQ61643320
P304page(s)342-349
P577publication date2011-12-13
P1433published inCancer ScienceQ326125
P1476titlePreclinical antitumor activity of the novel heat shock protein 90 inhibitor CH5164840 against human epidermal growth factor receptor 2 (HER2)-overexpressing cancers
P478volume103

Reverse relations

cites work (P2860)
Q34852929Association between HSP90 and Her2 in gastric and gastroesophageal carcinomas
Q39124519Enhanced antitumor activity of erlotinib in combination with the Hsp90 inhibitor CH5164840 against non-small-cell lung cancer
Q53091400Expression analysis of heat shock protein 90 (HSP90) and Her2 in colon carcinoma.
Q38973014Gallium-68-labeled anti-HER2 single-chain Fv fragment: development and in vivo monitoring of HER2 expression
Q42936269Heat Shock Protein 90 (HSP90) and Her2 in Adenocarcinomas of the Esophagus
Q39287689Inhibition of lymphatic metastasis in neuroblastoma by a novel neutralizing antibody to vascular endothelial growth factor-D.
Q39843650Regulation of Apoptosis by HER2 in Breast Cancer
Q28248791Selective targeting of the stress chaperome as a therapeutic strategy
Q37466405Suppression of inflammatory cascade is implicated in methyl amooranin-mediated inhibition of experimental mammary carcinogenesis
Q26765447Targeting Cell Survival Proteins for Cancer Cell Death
Q36347106Targeting heat-shock protein 90 with ganetespib for molecularly targeted therapy of gastric cancer
Q50959754The dual targeting of EGFR and ErbB2 with the inhibitor Lapatinib corrects high glucose-induced apoptosis and vascular dysfunction by opposing multiple diabetes-induced signaling changes

Search more.