The abundance of Met30p limits SCF(Met30p) complex activity and is regulated by methionine availability

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The abundance of Met30p limits SCF(Met30p) complex activity and is regulated by methionine availability is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.20.21.7845-7852.2000
P932PMC publication ID86396
P698PubMed publication ID11027256

P2093author name stringC Dixon
M G Goebl
N Mathias
D B Smothers
L Kozubowski
P2860cites workCdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34Q24602536
The COT2 gene is required for glucose-dependent divalent cation transport in Saccharomyces cerevisiaeQ24606217
The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitroQ24608829
Metabolism of sulfur amino acids in Saccharomyces cerevisiaeQ24643503
The ubiquitin systemQ27860803
Ubiquitin-dependent protein degradationQ27931143
Met30p, a yeast transcriptional inhibitor that responds to S-adenosylmethionine, is an essential protein with WD40 repeats.Q27931706
Feedback-regulated degradation of the transcriptional activator Met4 is triggered by the SCF(Met30 )complexQ27932747
Cdc53p acts in concert with Cdc4p and Cdc34p to control the G1-to-S-phase transition and identifies a conserved family of proteinsQ27933764
F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complexQ27934075
Cdc34 and the F-box protein Met30 are required for degradation of the Cdk-inhibitory kinase Swe1.Q27934879
GCN4 protein, synthesized in vitro, binds HIS3 regulatory sequences: implications for general control of amino acid biosynthetic genes in yeastQ27935053
The unstable F-box protein p58-Ctf13 forms the structural core of the CBF3 kinetochore complexQ27935572
SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-boxQ27936367
SCF ubiquitin protein ligases and phosphorylation-dependent proteolysisQ27937519
Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesisQ27938760
Ribosome-binding domain of eukaryotic initiation factor-2 kinase GCN2 facilitates translation controlQ27938904
A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1pQ27939049
Positive regulation in the general amino acid control of Saccharomyces cerevisiaeQ27939411
The Cdc42p effector Gic2p is targeted for ubiquitin-dependent degradation by the SCFGrr1 complexQ27939642
Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1.Q27940059
Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box proteincomplexes that regulate cell division and methionine biosynthesis in yeastQ27940196
The F-box: a new motif for ubiquitin dependent proteolysis in cell cycle regulation and signal transductionQ28139281
Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligaseQ28506124
SCF and Cullin/Ring H2-based ubiquitin ligasesQ29547637
Vectors for the inducible overexpression of glutathione S-transferase fusion proteins in yeastQ29618547
Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascadeQ29620459
A simple and efficient procedure for transformation of yeastsQ29620575
Grr1 of Saccharomyces cerevisiae is connected to the ubiquitin proteolysis machinery through Skp1: coupling glucose sensing to gene expression and the cell cycleQ33887490
The abundance of cell cycle regulatory protein Cdc4p is controlled by interactions between its F box and Skp1pQ33957380
The sulfur controller-2 negative regulatory gene of Neurospora crassa encodes a protein with beta-transducin repeatsQ34435598
An essential domain within Cdc34p is required for binding to a complex containing Cdc4p and Cdc53p in Saccharomyces cerevisiaeQ34455840
Degradation of the transcription factor Gcn4 requires the kinase Pho85 and the SCF(CDC4) ubiquitin-ligase complexQ34692221
Control of cell division in Saccharomyces cerevisiae by methionyl-tRNAQ35002489
SCF(Met30)-mediated control of the transcriptional activator Met4 is required for the G(1)-S transitionQ35008040
An additional role for the F-box motif: gene regulation within the Neurospora crassa sulfur control network.Q35918762
Intragenic suppression among CDC34 (UBC3) mutations defines a class of ubiquitin-conjugating catalytic domainsQ36555375
GRR1 of Saccharomyces cerevisiae is required for glucose repression and encodes a protein with leucine-rich repeatsQ36736572
Novel mutation causing derepression of several enzymes of sulfur metabolism in Neurospora crassaQ36774483
Amino acid signaling in Saccharomyces cerevisiae: a permease-like sensor of external amino acids and F-Box protein Grr1p are required for transcriptional induction of the AGP1 gene, which encodes a broad-specificity amino acid permeaseQ39610796
The Aspergillus nidulans sulphur regulatory gene sconB encodes a protein with WD40 repeats and an F-boxQ48039322
G1 cyclin turnover and nutrient uptake are controlled by a common pathway in yeastQ72613069
Ubiquitination and degradation of the substrate recognition subunits of SCF ubiquitin-protein ligasesQ77652490
Metabolism of sulfur amino acids in Saccharomyces cerevisiaeQ126946738
P433issue21
P407language of work or nameEnglishQ1860
P304page(s)7845-7852
P577publication date2000-11-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleThe abundance of Met30p limits SCF(Met30p) complex activity and is regulated by methionine availability
P478volume20

Reverse relations

cites work (P2860)
Q45978517A role for LKP2 in the circadian clock of Arabidopsis.
Q27931085Activation of the S-phase checkpoint inhibits degradation of the F-box protein Dia2
Q43895788Binding to Elongin C inhibits degradation of interacting proteins in yeast
Q39692225Cloning and characterization of scon-3+, a new member of the Neurospora crassa sulfur regulatory system.
Q21203558Cullin-RING ubiquitin ligases: global regulation and activation cycles
Q30709192Functional analysis of the Saccharomyces cerevisiae YFR021w/YGR223c/YPL100w ORF family suggests relations to mitochondrial/peroxisomal functions and amino acid signalling pathways
Q27938799Identification of residues in the WD-40 repeat motif of the F-box protein Met30p required for interaction with its substrate Met4p
Q64061044Multi-omics characterization of the necrotrophic mycoparasite Saccharomycopsis schoenii
Q34473396Overproduction of polypeptides corresponding to the amino terminus of the F-box proteins Cdc4p and Met30p inhibits ubiquitin ligase activities of their SCF complexes
Q38585206Proteolytic regulation of metabolic enzymes by E3 ubiquitin ligase complexes: lessons from yeast
Q36643830Regulation of cation balance in Saccharomyces cerevisiae
Q37448115Repression of sulfate assimilation is an adaptive response of yeast to the oxidative stress of zinc deficiency.
Q38346254Stability of homologue of Slimb F-box protein is regulated by availability of its substrate
Q36855414The emerging regulatory potential of SCFMet30 -mediated polyubiquitination and proteolysis of the Met4 transcriptional activator
Q39686868The replication stress response and the ubiquitin system: a new link in maintaining genomic integrity

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