| scholarly article | Q13442814 |
| P50 | author | Tetyana Klymenko | Q64678861 |
| Caroline Dive | Q30119872 | ||
| Guy Makin | Q61266306 | ||
| P2093 | author name string | Martin Brandenburg | |
| Christopher Morrow | |||
| P2860 | cites work | The Hallmarks of Cancer | Q221226 |
| The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis | Q22009936 | ||
| High-level expression of angiogenic factors is associated with advanced tumor stage in human neuroblastomas | Q73803428 | ||
| Upgrading the BCL-2 network | Q79397659 | ||
| BH3-only protein Noxa is a mediator of hypoxic cell death induced by hypoxia-inducible factor 1alpha | Q24303563 | ||
| Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension | Q24307473 | ||
| Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia | Q24313505 | ||
| Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein | Q24599442 | ||
| Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation | Q27860876 | ||
| Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects | Q28200181 | ||
| Hypoxia--a key regulatory factor in tumour growth | Q29547318 | ||
| The BCL-2 protein family: opposing activities that mediate cell death | Q29547380 | ||
| An inhibitor of Bcl-2 family proteins induces regression of solid tumours | Q29547595 | ||
| ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor | Q29616727 | ||
| Therapeutic efficacy of ABT-737, a selective inhibitor of BCL-2, in small cell lung cancer | Q33326515 | ||
| Treatment of high-risk neuroblastoma with intensive chemotherapy, radiotherapy, autologous bone marrow transplantation, and 13-cis-retinoic acid. Children's Cancer Group | Q33876841 | ||
| Hypoxia alters gene expression in human neuroblastoma cells toward an immature and neural crest-like phenotype | Q34068218 | ||
| Antagonism of cytotoxic chemotherapy in neuroblastoma cell lines by 13-cis-retinoic acid is mediated by the antiapoptotic Bcl-2 family proteins | Q35238042 | ||
| A decade of caspases | Q35591686 | ||
| Loss of Mcl-1 protein and inhibition of electron transport chain together induce anoxic cell death | Q35641895 | ||
| BH3 response profiles from neuroblastoma mitochondria predict activity of small molecule Bcl-2 family antagonists | Q36948615 | ||
| Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance | Q37011260 | ||
| Mcl1 downregulation sensitizes neuroblastoma to cytotoxic chemotherapy and small molecule Bcl2-family antagonists. | Q37163339 | ||
| Bcl-2 inhibitors: small molecules with a big impact on cancer therapy | Q37275477 | ||
| Hypoxia-inducible factor-1-dependent overexpression of myeloid cell factor-1 protects hypoxic cells against tert-butyl hydroperoxide-induced apoptosis | Q38332838 | ||
| Hypoxic human cancer cells are sensitized to BH-3 mimetic–induced apoptosis via downregulation of the Bcl-2 protein Mcl-1. | Q39577806 | ||
| Initial testing (stage 1) of the BH3 mimetic ABT-263 by the pediatric preclinical testing program | Q40034582 | ||
| Chronic hypoxia promotes hypoxia-inducible factor-1alpha-dependent resistance to etoposide and vincristine in neuroblastoma cells. | Q40229813 | ||
| Reversing hypoxic cell chemoresistance in vitro using genetic and small molecule approaches targeting hypoxia inducible factor-1. | Q40357279 | ||
| HIF-1alpha has an anti-apoptotic effect in human airway epithelium that is mediated via Mcl-1 gene expression | Q40361246 | ||
| A hypoxia-driven vascular endothelial growth factor/Flt1 autocrine loop interacts with hypoxia-inducible factor-1alpha through mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2 pathway in neuroblastoma | Q40384745 | ||
| The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized. | Q42064781 | ||
| Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation | Q44926251 | ||
| Scintigraphic response by 123I-metaiodobenzylguanidine scan correlates with event-free survival in high-risk neuroblastoma | Q45086550 | ||
| Sulforhodamine B colorimetric assay for cytotoxicity screening. | Q51032435 | ||
| A simple generalized equation for the analysis of multiple inhibitions of Michaelis-Menten kinetic systems. | Q52437888 | ||
| Role of hypoxia inducible factor-1 alpha in modulation of apoptosis resistance | Q57243526 | ||
| P433 | issue | 12 | |
| P921 | main subject | hypoxia | Q105688 |
| neuroblastoma | Q938205 | ||
| drug resistance | Q12147416 | ||
| P304 | page(s) | 2373-2383 | |
| P577 | publication date | 2011-10-17 | |
| P1433 | published in | Molecular Cancer Therapeutics | Q2363144 |
| P1476 | title | The novel Bcl-2 inhibitor ABT-737 is more effective in hypoxia and is able to reverse hypoxia-induced drug resistance in neuroblastoma cells | |
| P478 | volume | 10 |
| Q90590054 | A direct comparison of selective BH3-mimetics reveals BCL-XL, BCL-2 and MCL-1 as promising therapeutic targets in neuroblastoma |
| Q36201760 | Acidosis promotes Bcl-2 family-mediated evasion of apoptosis: involvement of acid-sensing G protein-coupled receptor Gpr65 signaling to Mek/Erk |
| Q42061450 | Anti-cancer drug discovery and development: Bcl-2 family small molecule inhibitors |
| Q38643329 | BMX acts downstream of PI3K to promote colorectal cancer cell survival and pathway inhibition sensitizes to the BH3 mimetic ABT-737. |
| Q39170892 | Characterization of neuroblastoma bone invasion/metastasis in established bone metastatic model of SY5Y and KCNR cell lines |
| Q54969934 | Deconstructing Signaling Pathways in Cancer for Optimizing Cancer Combination Therapies. |
| Q37418248 | Hypoxia modulates the activity of a series of clinically approved tyrosine kinase inhibitors |
| Q28533909 | Hypoxia-induced cytotoxic drug resistance in osteosarcoma is independent of HIF-1Alpha |
| Q49334960 | Influence of hypoxia-related genetic polymorphisms on the prognosis of patients with metastatic gastric cancer treated with EOF. |
| Q38841695 | Oncolytic viral therapy for neuroblastoma cells with Sindbis virus AR339 strain |
| Q36086722 | Pro-survival responses to the dual inhibition of anti-apoptotic Bcl-2 family proteins and mTOR-mediated signaling in hypoxic colorectal carcinoma cells |
| Q35878431 | Rapamycin rescues ABT-737 efficacy in small cell lung cancer |
| Q58648224 | Screening of Cytotoxicity and Anti-Inflammatory Properties of Feijoa Extracts Using Genetically Modified Cell Models Targeting TLR2, TLR4 and NOD2 Pathways, and the Implication for Inflammatory Bowel Disease |
| Q42117299 | Understanding sensitivity to BH3 mimetics: ABT-737 as a case study to foresee the complexities of personalized medicine |
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