Doxazosin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in mild or moderate hypertension

scientific article published on May 1988

Doxazosin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in mild or moderate hypertension is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P6179Dimensions Publication ID1052275933
P356DOI10.2165/00003495-198835050-00003
P8608Fatcat IDrelease_j7uh2q477fdihdme5oxwt7nram
P698PubMed publication ID2899495

P50authorRex N. BrogdenQ62563651
P2093author name stringR A Young
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Antihypertensive effect of doxazosin in hypertensive patients: comparison with atenololQ34446847
Double-blind comparison of the effects of long-term treatment with doxazosin or atenolol on serum lipoproteinsQ34446855
Multicentre 12-week double-blind comparison of doxazosin, prazosin and placebo in patients with mild to moderate essential hypertensionQ34446862
The pharmacokinetics of doxazosin in elderly normotensivesQ34447659
Effect of propranolol and prazosin on blood lipids. The Oslo StudyQ72425748
Prazosin and its analogues UK-18,596 and UK-33,274: a comparative study on cardiovascular effects and alpha-adrenoceptor blocking activitiesQ72429905
The pharmacology of antihypertensive drugs with special reference to vasodilators, alpha-adrenergic blocking agents and prazosinQ39169739
The pharmacological classification of adrenergic alpha 1 and alpha 2 receptors and their mechanisms of actionQ39290815
The Tromsø heart-study. High-density lipoprotein and coronary heart-disease: a prospective case-control studyQ39433797
The effects of antihypertensive drugs on serum lipids and lipoproteins. II. Non-diuretic drugsQ39460803
Mechanism of alpha blockade for blood pressure controlQ39462956
The effects of antihypertensive drugs on serum lipids and lipoproteins, I. DiureticsQ39743407
Hepatic vascular bed.Q40061000
The emerging problem of plasma lipid changes during antihypertensive therapyQ40103502
Suppression of renin secretion in the rat kidney by a nonvascular alpha-adrenergic mechanismQ40251614
Multicenter, double-blind comparison of doxazosin and atenolol in patients with mild to moderate hypertensionQ41761965
The alpha 1-adrenoceptor antagonist profile of doxazosin: preclinical pharmacologyQ42101154
Doxazosin, an alpha 1-adrenoceptor antagonist: pharmacokinetics and concentration-effect relationships in manQ42116080
Serum lipid changes in a one-year, multicenter, double-blind comparison of doxazosin and atenolol for mild to moderate essential hypertensionQ42127517
Clinical pharmacology and therapeutic role of prazosin and related alpha-adrenoceptor antagonistsQ42201649
A comparison of the effects of doxazosin and alfuzosin with those of urapidil on preganglionic sympathetic nerve activity in anaesthetised catsQ42206140
Mediation of Renin Release in Essential Hypertension by α-AdrenoreceptorsQ42243100
Within patient comparison of prazosin and UK-33,274. A new alpha-adrenoceptor-antagonistQ42664441
The metabolism and kinetics of doxazosin in man, mouse, rat and dog.Q43181893
A pharmacodynamic and pharmacokinetic assessment of a new alpha- adrenoceptor antagonist, doxazosin (UK33274) in normotensive subjectsQ43241370
Vascular alpha-adrenoceptors in man: interactions with adrenaline and noradrenalineQ43535785
Doxazosin increases low density lipoprotein receptor activity.Q43765013
Selectivity of benzodioxane alpha-adrenoceptor antagonists for alpha 1- and alpha 2-adrenoceptors determined by binding affinityQ48857160
Effect of Ca2+ blocking agents on the metabolism of low density lipoproteins in human skin fibroblasts.Q51860265
Application of pharmacokinetic-pharmacodynamic modelling for the comparison of quinazoline alpha-adrenoceptor agonists in normotensive volunteers.Q52671776
An open one-year comparison of doxazosin and prazosin for mild to moderate essential hypertension.Q54136300
Clinical pharmacology of doxazosin in patients with essential hypertension.Q54137765
Effect of doxazosin on blood pressure and renal haemodynamics of hypertensive patients with renal failure.Q54142086
Postjunctional Selectivity of α-Blockade with Prazosin, Trimazosin, and UK-33,274 in ManQ54526678
Renal response to propranolol treatment in hypertensive humansQ54526936
Epidemiology of coronary heart disease: the Framingham study.Q55062740
The effect of oral prazosin on blood pressure and plasma concentrations of renin and angiotensin II in manQ57403531
The Metabolic Fate of PrazosinQ67066721
Neural regulation of renin release: experimental evidence and clinical implications in arterial hypertensionQ67693493
Antihypertensive effects and pharmacokinetics of single and consecutive administration of doxazosin in patients with mild to moderate essential hypertensionQ69000047
Differences between exogenous and endogenous noradrenaline in the effects on vascular post-synaptic alpha 1- and alpha 2-adrenoceptors in manQ69855782
Efficacy and safety of doxazosin in hypertension therapyQ69900508
A multicenter trial of doxazosin in West GermanyQ69900510
A double-blind parallel trial to assess the efficacy of doxazosin, atenolol and placebo in patients with mild to moderate systemic hypertensionQ69900529
Antihypertensive effects of doxazosin in systemic hypertension and comparison with terazosinQ69900531
Comparative effects of doxazosin and hydrochlorothiazide on serum lipids and blood pressure in essential hypertensionQ69900534
Pharmacokinetics and effect on blood pressure of doxazosin in normal subjects and patients with renal failureQ70014856
A 24-week multicenter double-blind study of doxazosin and hydrochlorothiazide in patients with mild to moderate essential hypertensionQ70033587
Effect of sympathetic stimulation and intrarenal alpha-blockade on the secretion of renin by the human kidneyQ70100692
Identification of vascular postsynaptic alpha 1- and alpha 2-adrenoceptors in manQ70201024
Determination of the vasodilator UK33274 by high-performance liquid chromatography using fluorescence detectionQ70537765
Comparative effects of prazosin and atenolol on plasma lipids in hypertensive patientsQ71286907
P433issue5
P921main subjectarterial hypertensionQ41861
pharmacokineticsQ323936
pharmacodynamicsQ725307
P304page(s)525-541
P577publication date1988-05-01
P1433published inDrugsQ3040094
P1476titleDoxazosin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in mild or moderate hypertension
P478volume35

Reverse relations

cites work (P2860)
Q33147811A postmarketing, open-label study to evaluate the tolerability and effectiveness of replacing standard-formulation doxazosin with doxazosin in the gastrointestinal therapeutic system formulation in adult patients with hypertension.
Q37608000Alpha-adrenergic blockers: mechanism of action, blood pressure control, and effects of lipoprotein metabolism
Q40487133An Overview of the Pharmacodynamic Properties and Therapeutic Potential of Combined α- and β-Adrenoceptor Antagonists
Q39243477Antihypertensive drugs interacting with alpha- and beta-adrenoceptors. A review of basic pharmacology
Q40708111Antihypertensive therapy in the geriatric patient: II. A review of the alpha1-adrenergic blocking agents
Q36859820Benign prostatic hyperplasia. Practical treatment guidelines
Q77952123Clinical correlation of maximal urinary flow rate and plasma doxazosin concentrations in the treatment of benign prostatic hyperplasia. Multicenter Study Group
Q36834798Comparison of the antagonistic activity of tamsulosin and doxazosin at vascular alpha 1-adrenoceptors in humans
Q42282267Doxazosin versus nitrendipine: a double-blind comparative study in patients adhering to a sodium-restricted diet
Q70964336Doxazosin--an alpha-1 receptor blocking agent in the long-term management of benign prostatic hyperplasia (BPH) (Part Two)
Q40399993Doxazosin. An update of its clinical pharmacology and therapeutic applications in hypertension and benign prostatic hyperplasia
Q51607749Effect of doxazosin on insulin sensitivity in hypertensive non-insulin dependent diabetic patients
Q35803015Endocrine and adrenergic pharmacological intervention in diseases of the prostate
Q43868885Flow injection analysis of doxazosin mesylate using UV-detection
Q34707738Induction of apoptosis in the prostate by alpha1-adrenoceptor antagonists: a novel effect of "old" drugs
Q35032547Induction of prostate apoptosis by alpha1-adrenoceptor antagonists: mechanistic significance of the quinazoline component
Q34317675Lessons learned from prematurely terminated clinical trials
Q44537299Lower urinary tract symptoms, pain and quality of life assessment in chronic non-bacterial prostatitis patients treated with alpha-blocking agent doxazosin; versus placebo
Q26752782Microwave-Assisted Synthesis of Bioactive Six-Membered Heterocycles and Their Fused Analogues
Q40071688Naftopidil, a selective alpha-1 adrenoceptor antagonist, inhibits growth of human prostate cancer cells by G1 cell cycle arrest
Q37677533Newer antihypertensive agents
Q38367793Pharmacokinetic-pharmacodynamic relationships of alpha-adrenoceptor antagonists
Q37268536Pharmacokinetics of newer drugs in patients with renal impairment (Part II).
Q74603170Pulse polarographic (constant and increasing) determinations of doxazosin in pharmaceutical tablets
Q36648945Quinazoline-based alpha 1-adrenoceptor antagonists induce prostate cancer cell apoptosis via TGF-beta signalling and I kappa B alpha induction
Q37728436Stereoselective binding of doxazosin enantiomers to plasma proteins from rats, dogs and humans in vitro
Q40755243The effect of doxazosin, urapidil and indoramin pretreatment on fever produced by E. coli lipopolysaccharide in rabbits
Q42013212The potentiation of adrenaline‐induced in vitro platelet aggregation by ADP, collagen and serotonin and its inhibition by naftopidil and doxazosin in normal human subjects
Q43620119Voltammetric determination of doxazosin in tablets using rotating platinum electrode

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