Pharmacokinetic-pharmacodynamic contributions to the convulsant activity of fluoroquinolones in rats

scientific article published on June 1999

Pharmacokinetic-pharmacodynamic contributions to the convulsant activity of fluoroquinolones in rats is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/AAC.43.6.1511
P932PMC publication ID89311
P698PubMed publication ID10348785

P50authorWilliam CouetQ39755800
P2093author name stringS Bouquet
F Huguet
P Courtois
A Delon
V Brunet
P2860cites workSelective antagonism of the GABA(A) receptor by ciprofloxacin and biphenylacetic acidQ24672818
Structure-activity and structure-side-effect relationships for the quinolone antibacterialsQ28246405
Convulsions related to enoxacinQ28282076
Central nervous system toxicity of quinolones: human and animal findingsQ28329722
A new approach for early assessment of the epileptogenic potential of quinolonesQ28369049
Quinolone therapy for infections of the central nervous systemQ30459934
Determination of the excitatory potencies of fluoroquinolones in the central nervous system by an in vitro modelQ33694475
Structure-epileptogenicity relationship of quinolones with special reference to their interaction with gamma-aminobutyric acid receptor sitesQ35354313
The fluoroquinolones: pharmacology, clinical uses, and toxicities in humansQ35572870
Fluorinated quinolones. A review of their mode of action, antimicrobial activity, pharmacokinetics and clinical efficacyQ39730719
Effects of some excitatory amino acid antagonists and drugs enhancing gamma-aminobutyric acid neurotransmission on pefloxacin-induced seizures in DBA/2 miceQ39783683
Inhibitory effects of quinolone antibacterial agents on gamma-aminobutyric acid binding to receptor sites in rat brain membranesQ39817630
Quinolones, theophylline, and diclofenac interactions with the gamma-aminobutyric acid receptorQ39832593
Transport of quinolone antibacterial drugs by human P-glycoprotein expressed in a kidney epithelial cell line, LLC-PK1.Q41097269
Neurochemical studies on quinolone antibiotics: effects on glutamate, GABA and adenosine systems in mammalian CNS.Q42199003
Kinetics of drug action in disease states. XVI. Pharmacodynamics of theophylline-induced seizures in rats.Q42216347
Pharmacokinetic-pharmacodynamic contributions to the convulsant activity of pefloxacin and norfloxacin in rats.Q42551258
Norfloxacin and SeizuresQ42659355
Kinetics of drug action in disease states. XIV. Effect of infusion rate on pentylenetetrazol concentrations in serum, brain and cerebrospinal fluid of rats at onset of convulsionsQ45260293
Cerebrospinal fluid transport and disposition of the quinolones ciprofloxacin and pefloxacin in ratsQ48399628
Kinetic evidence for active efflux transport across the blood-brain barrier of quinolone antibiotics.Q48616323
Inhibitory effect of new quinolones on GABA(A) receptor-mediated response and its potentiation with felbinac in Xenopus oocytes injected with mouse-brain mRNA: correlation with convulsive potency in vivoQ48649077
Quinolones and fenbufen interact with GABAA receptor in dissociated hippocampal cells of ratQ48683939
Kinetics of drug action in disease states. I. Effect of infusion rate on phenobarbital concentrations in serum, brain and cerebrospinal fluid of normal rats at onset of loss of righting reflexQ48686282
Characterization of the transport properties of a quinolone antibiotic, fleroxacin, in rat choroid plexusQ49037581
Development of a new quantitative approach for the isobolographic assessment of the convulsant interaction between pefloxacin and theophylline in rats.Q52238784
Ciprofloxacin: an update on clinical experience.Q54408297
Attenuated inhibition by levofloxacin, l-isomer of ofloxacin, on GABA response in the dissociated rat hippocampal neuronsQ71525856
Comparative study of permeability into rat cerebrospinal fluid of the quinolones: dependency on their lipophilicitiesQ72342358
Levofloxacin, an optical isomer of ofloxacin, has attenuated epileptogenic activity in mice and inhibitory potency in GABA receptor bindingQ72505601
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectpharmacokineticsQ323936
pharmacodynamicsQ725307
P1104number of pages5
P304page(s)1511-1515
P577publication date1999-06-01
P1433published inAntimicrobial Agents and ChemotherapyQ578004
P1476titlePharmacokinetic-pharmacodynamic contributions to the convulsant activity of fluoroquinolones in rats
P478volume43

Reverse relations

cites work (P2860)
Q52082687Antagonistic interaction between the convulsant activities of pefloxacin and its main metabolite norfloxacin in rats.
Q34130062Clinical use of the fluoroquinolones
Q43294249Convulsant activity and pharmacokinetic-pharmacodynamic modeling of the electroencephalogram effect of gemifloxacin in rats
Q34104957Convulsant and subconvulsant doses of norfloxacin in the presence and absence of biphenylacetic acid alter extracellular hippocampal glutamate but not gamma-aminobutyric acid levels in conscious rats
Q27312442Direct Optofluidic Measurement of the Lipid Permeability of Fluoroquinolones
Q43908872Ignoring pharmacokinetics may lead to isoboles misinterpretation: illustration with the norfloxacin-theophylline convulsant interaction in rats
Q40839217In vitro and in vivo investigations on fluoroquinolones; effects of the P-glycoprotein efflux transporter on brain distribution of sparfloxacin.
Q44318852Inhibition by fluoroquinolones of K(+) currents in rat dissociated hippocampal neurons
Q35846371Moxifloxacin Induced Seizures -A Case Report
Q43181780Norfloxacin blood-brain barrier transport in rats is not affected by probenecid coadministration
Q39477395Pharmacokinetic-pharmacodynamic modeling of the electroencephalogram effect of imipenem in healthy rats
Q39755517Pharmacokinetic-pharmacodynamic modeling of the electroencephalogram effect of norfloxacin in rats.
Q35042172Pharmacokinetic-pharmacodynamic modelling of the convulsant interaction between norfloxacin and biphenyl acetic acid in rats.
Q42951097The Effect of Ciprofloxacin Injection on Genetically Absence Prone (Wag/Rij) Rat's Electroencephalogram Characteristics.

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