Genetic and epigenetic changes of HPV16 in cervical cancer differentially regulate E6/E7 expression and associate with disease progression

scientific article published on 10 September 2011

Genetic and epigenetic changes of HPV16 in cervical cancer differentially regulate E6/E7 expression and associate with disease progression is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.YGYNO.2011.08.004
P8608Fatcat IDrelease_pce3gn5ovnff5j27jawfrsxmum
P698PubMed publication ID21911249

P2093author name stringSusanta Roychoudhury
Chinmay Kumar Panda
Chandraditya Chakraborty
Dipanjana Mazumder Indra
Partha Sarathi Basu
Ranajit Kumar Mondal
Ratnesh Kumar Singh
Sankhadeep Dutta
Sraboni Mitra
P2860cites workThe E7 oncoprotein is translated from spliced E6*I transcripts in high-risk human papillomavirus type 16- or type 18-positive cervical cancer cell lines via translation reinitiationQ24545831
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
Global cancer statistics, 2002Q27860562
Human papillomavirus is a necessary cause of invasive cervical cancer worldwideQ29617514
Integrated human papillomavirus type 16 is frequently found in cervical cancer precursors as demonstrated by a novel quantitative real-time PCR techniqueQ33951730
Prevalence of human papillomavirus in cervical cancer: a worldwide perspective. International biological study on cervical cancer (IBSCC) Study GroupQ34313864
Human papillomavirus type 16 E2 protein has no effect on transcription from episomal viral DNA.Q34467609
Human papillomaviruses and their role in cervical cancerQ34477831
Estimating the world cancer burden: Globocan 2000.Q34518922
Integration of human papillomavirus type 16 DNA into the human genome leads to increased stability of E6 and E7 mRNAs: implications for cervical carcinogenesisQ34641385
Human papillomavirus type 16 integration in cervical carcinoma in situ and in invasive cervical cancer.Q34680748
CpG methylation of human papillomavirus type 16 DNA in cervical cancer cell lines and in clinical specimens: genomic hypomethylation correlates with carcinogenic progressionQ34996306
Early integration of high copy HPV16 detectable in women with normal and low grade cervical cytology and histologyQ35769572
YY1 represses human papillomavirus type 16 transcription by quenching AP-1 activity.Q35869296
Human papillomavirus type 16 sequence variation in cervical cancers: a worldwide perspectiveQ35879712
Molecular biology of human papillomavirus infection and cervical cancerQ36441612
Human papillomavirus type 16 variant analysis of E6, E7, and L1 genes and long control region in biopsy samples from cervical cancer patients in north IndiaQ36497960
Oncogenic and nononcogenic human genital papillomaviruses generate the E7 mRNA by different mechanismsQ36781994
Integration of high-risk human papillomavirus: a key event in cervical carcinogenesis?Q36851090
Methylation Patterns of Papillomavirus DNA, Its Influence on E2 Function, and Implications in Viral InfectionQ37060103
Human papillomavirus type 16 E2 and E6 are RNA-binding proteins and inhibit in vitro splicing of pre-mRNAs with suboptimal splice sitesQ37194934
Conserved methylation patterns of human papillomavirus type 16 DNA in asymptomatic infection and cervical neoplasiaQ37596549
The E6/E7 promoter of extrachromosomal HPV16 DNA in cervical cancers escapes from cellular repression by mutation of target sequences for YY1.Q37630368
Identification and functional analysis of sequence rearrangements in the long control region of human papillomavirus type 16 Af-1 variants isolated from Ugandan penile carcinomasQ38885650
Methylation of the long control region of HPV16 is related to the severity of cervical neoplasiaQ39789073
Clonal selection for transcriptionally active viral oncogenes during progression to cancer.Q40163392
Splicing of a cap-proximal human Papillomavirus 16 E6E7 intron promotes E7 expression, but can be restrained by distance of the intron from its RNA 5' cap.Q40573123
Expression and splicing patterns of human papillomavirus type‐16 mrnas in pre‐cancerous lesions and carcinomas of the cervix, in human keratinocytes immortalized by HPV 16, and in cell lines established from cervical cancersQ41642805
Detection of novel splicing patterns in a HPV16-containing keratinocyte cell lineQ41723300
Human papillomavirus type 16 E6 and E7 gene variations in Indian cervical cancerQ42689798
CpG methylation of HPV 16 LCR at E2 binding site proximal to P97 is associated with cervical cancer in presence of intact E2.Q43785734
Enhanced oncogenicity of Asian-American human papillomavirus 16 is associated with impaired E2 repression of E6/E7 oncogene transcription.Q47421360
Prediction of human papillomavirus 16 e6 gene expression and cervical intraepithelial neoplasia progression by methylation statusQ47903873
Association of human papillomavirus type 16 integration in the E2 gene with poor disease-free survival from cervical cancer.Q52524013
Disruption of the E1 and E2 reading frames of HPV 16 in cervical carcinoma is associated with poor prognosis.Q52530292
Physical status of HPV-16 in esophageal squamous cell carcinoma.Q52561447
HPV16 E2 gene disruption and polymorphisms of E2 and LCR: some significant associations with cervical cancer in Indian women.Q52566810
Integration of human papillomavirus type-16 and type-18 is a very early event in cervical carcinogenesis.Q53224037
Viral load, E2 gene disruption status, and lineage of human papillomavirus type 16 infection in cervical neoplasia.Q54571263
HPV 16 E6 sequence variations in Indian patients with cervical neoplasia.Q54660436
The predominant mRNA class in HPV16-infected genital neoplasias does not encode the E6 or the E7 proteinQ72618326
Prevalence of deletions of YY1-binding sites in episomal HPV 16 DNA from cervical cancersQ72721263
Microsatellite instability in squamous cell carcinoma of head and neck from the Indian patient populationQ73758307
Cancer patterns in eastern India: the first report of the Kolkata cancer registryQ74456173
Mutational and functional analysis of HPV-16 URR derived from Korean cervical neoplasiaQ77933202
Human papillomavirus prevalence in postradiotherapy uterine cervical carcinoma patients: correlation with recurrence of the diseaseQ79799651
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectcervix uterine cancerQ160105
mutationQ42918
P304page(s)597-604
P577publication date2011-09-10
P1433published inGynecologic OncologyQ5625182
P1476titleGenetic and epigenetic changes of HPV16 in cervical cancer differentially regulate E6/E7 expression and associate with disease progression
P478volume123

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cites work (P2860)
Q64883157Advances in biomarkers and treatment strategies for HPV-associated head and neck cancer.
Q36104985CpG Methylation Analysis of HPV16 in Laser Capture Microdissected Archival Tissue and Whole Tissue Sections from High Grade Anal Squamous Intraepithelial Lesions: A Potential Disease Biomarker
Q48114614DNA methylation regulated microRNAs in human cervical cancer.
Q41135246Different DNA methylation pattern of HPV16, HPV18 and HPV51 genomes in asymptomatic HPV infection as compared to cervical neoplasia
Q54267797Distribution of HPV-16 variants among isolates from Paraguayan women with different grades of cervical lesion.
Q92142218E6‑regulated overproduction of prostaglandin E2 may inhibit migration of dendritic cells in human papillomavirus 16‑positive cervical lesions
Q38598051Epigenetic Alterations in Human Papillomavirus-Associated Cancers
Q37293605Epigenetics of human papillomaviruses
Q36459298Folate and vitamin B12 may play a critical role in lowering the HPV 16 methylation-associated risk of developing higher grades of CIN.
Q93107818Genetic diversity and phylogenetic analysis of HPV 16 & 18 variants isolated from cervical specimens of women in Saudi Arabia
Q42270103Genome-wide DNA methylation assay reveals novel candidate biomarker genes in cervical cancer
Q53176137HPV DNA methylation at the early promoter and E1/E2 integrity: A comparison between HPV16, HPV18 and HPV45 in cervical cancer.
Q33830609Human papillomavirus 16 non-European variants are preferentially associated with high-grade cervical lesions
Q36876059Human papillomavirus DNA methylation as a potential biomarker for cervical cancer
Q38069444Human papillomavirus early proteins and apoptosis
Q38172151Human papillomavirus oncoproteins and apoptosis (Review).
Q40373938Identification of Changes in the Human Papilloma Virus 16 (HPV16) Genome During Early Dissemination of Cervical Cancer Cells May Complement Histological Diagnosis of Lymph Node Metastasis
Q49462526Identification of reliable biomarkers of human papillomavirus 16 methylation in cervical lesions based on integration status using high-resolution melting analysis.
Q38902393Infection and integration of high-risk human papillomavirus in HPV-associated cancer cells
Q36414507Lack of methylation in the upstream region of human papillomavirus type 6 from aerodigestive tract papillomas
Q40356767Methylation at 3'LCR of HPV16 can be affected by patient age and disruption of E1 or E2 genes.
Q37264251Methylation of human papillomavirus Type 16 CpG sites at E2-binding site 1 (E2BS1), E2BS2, and the Sp1-binding site in cervical cancer samples as determined by high-resolution melting analysis-PCR.
Q41921904Phylogenetic analysis of Human Papillomavirus 16 variants isolated from Indian Breast cancer patients showed difference in genetic diversity with that of Cervical cancer isolates
Q38922687Physical and methylation status of human papillomavirus 16 in asymptomatic cervical infections changes with malignant transformation
Q35097588Promoter hypermethylation of KLF4 inactivates its tumor suppressor function in cervical carcinogenesis
Q36292980Study of association and molecular analysis of human papillomavirus in breast cancer of Indian patients: Clinical and prognostic implication.
Q36281637Viral E6 is overexpressed via high viral load in invasive cervical cancer with episomal HPV16.
Q34506898Viral load, integration and methylation of E2BS3 and 4 in human papilloma virus (HPV) 16-positive vaginal and vulvar carcinomas
Q53161544Zebularine inhibits the growth of HeLa cervical cancer cells via cell cycle arrest and caspase-dependent apoptosis.

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