Long-term nitric oxide deficiency causes muscarinic supersensitivity and reduces beta(3)-adrenoceptor-mediated relaxation, causing rat detrusor overactivity

scientific article published on 25 February 2008

Long-term nitric oxide deficiency causes muscarinic supersensitivity and reduces beta(3)-adrenoceptor-mediated relaxation, causing rat detrusor overactivity is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/BJP.2008.39
P932PMC publication ID2438257
P698PubMed publication ID18297104
P5875ResearchGate publication ID5555324

P50authorGilberto de NucciQ5561420
Marcelo N. MuscaraQ47504443
Edson AntunesQ56686201
Angelina ZanescoQ61784604
P2093author name stringF Z T Mónica
C S Porto
S A Teixeira
F M F Abdalla
A A O Bricola
F R Báu
L L Lopes Freitas
P2860cites workA rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingQ25938984
How widespread are the symptoms of an overactive bladder and how are they managed? A population-based prevalence studyQ28202479
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Multiple functional defects in peripheral autonomic organs in mice lacking muscarinic acetylcholine receptor gene for the M3 subtypeQ28591691
Muscarinic receptor subtypes modulating smooth muscle contractility in the urinary bladderQ33539504
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Urinary bladder contraction and relaxation: physiology and pathophysiologyQ34335220
Prevalence and burden of overactive bladder in the United StatesQ34534593
Species differences in the distribution of beta-adrenoceptor subtypes in bladder smooth muscleQ35027616
Muscarinic receptor subtypes and management of the overactive bladderQ35031220
Beta 3-adrenoceptor stimulation induces vasorelaxation mediated essentially by endothelium-derived nitric oxide in rat thoracic aortaQ35041493
Mechanisms of beta 3-adrenoceptor-induced eNOS activation in right atrial and left ventricular human myocardiumQ35048451
Nitric oxide and the lower urinary tract: current concepts, future prospects.Q35155888
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Muscarinic receptors: their distribution and function in body systems, and the implications for treating overactive bladderQ35546189
Muscarinic acetylcholine receptor subtypes mediating urinary bladder contractility and coupling to GTP binding proteins.Q35751759
Effects of inhibition of the L-arginine/nitric oxide pathway in the rat lower urinary tract in vivo and in vitroQ35870798
Calcium events in smooth muscles and their interstitial cells; physiological roles of sparksQ36272888
Anticholinergic drugs in patients with bladder outlet obstruction and lower urinary tract symptoms: A systematic reviewQ36576184
The negative inotropic effect of beta3-adrenoceptor stimulation is mediated by activation of a nitric oxide synthase pathway in human ventricle.Q37385274
Activation of alpha 1-adrenoceptors increases [3H]inositol metabolism in rat vas deferens and caudal arteryQ41898421
Chronic nitric oxide inhibition model six years on.Q42087123
Pharmacological characterization of beta-adrenoceptors mediating relaxation of the rat urinary bladder in vitroQ43194368
Chronic inhibition of nitric oxide synthesis. A new model of arterial hypertensionQ43420596
Localization of constitutive nitric oxide synthase isoforms and the nitric oxide target enzyme soluble guanylyl cyclase in the human bladderQ43601081
Beta-adrenoceptor agonists stimulate endothelial nitric oxide synthase in rat urinary bladder urothelial cells.Q44132595
Relationship of mass of obstructed rat bladders and responsiveness to adrenergic stimulationQ44156959
Different distribution of nitric oxide synthase and soluble guanylyl cyclase activities in the detrusor and proximal urethra of the rabbitQ44190433
Activity and expression of nitric oxide synthase in the hypertrophied rat bladder and the effect of nitric oxide on bladder smooth muscle growthQ44222832
Upregulation of muscarinic receptors by long-term nitric oxide inhibition in the rat ileum.Q44326264
Inducible nitric oxide synthase promotes pathophysiological consequences of experimental bladder outlet obstructionQ44357454
A quantitative analysis of mRNA expression of alpha 1 and beta-adrenoceptor subtypes and their functional roles in human normal and obstructed bladdersQ44508678
The M2 muscarinic receptor mediates contraction through indirect mechanisms in mouse urinary bladderQ44515675
Regional difference in functional roles of cAMP and cGMP in lower urinary tract smooth muscle contractilityQ44855670
Endothelial beta3-adrenoceptors mediate vasorelaxation of human coronary microarteries through nitric oxide and endothelium-dependent hyperpolarization.Q45012617
Cystometric findings in mice lacking muscarinic M2 or M3 receptorsQ45147269
Demonstration of bladder selective muscarinic receptor binding by intravesical oxybutynin to treat overactive bladderQ45148627
Advantages for transdermal over oral oxybutynin to treat overactive bladder: Muscarinic receptor binding, plasma drug concentration, and salivary secretionQ46799844
Purification of insoluble nitric oxide synthase from rat cerebellumQ48488531
Overactive bladder: prevalence and implications in Brazil.Q48511621
Effects of gender, age and hypertension on beta-adrenergic receptor function in rat urinary bladder.Q51802425
Human Idiopathic and Neurogenic Overactive Bladders and the Role of M2 Muscarinic Receptors in ContractionQ61613696
Bladder instability and denervation in patients with bladder outflow obstructionQ68532884
The inositol phosphate/diacylglycerol pathway in MA-10 Leydig tumor cells. Activation by arginine vasopressin and lack of effect of epidermal growth factor and human choriogonadotropinQ69737581
Co-existence of nitrergic, peptidergic and acetylcholine esterase-positive nerves in the pig lower urinary tractQ71893325
Physiological and morphometric studies into the pathophysiology of detrusor hyperreflexia in neuropathic patientsQ72151904
Long-term nitric oxide inhibition and chronotropic responses in rat isolated right atriaQ73087502
Urinary bladder-urethral sphincter dysfunction in mice with targeted disruption of neuronal nitric oxide synthase models idiopathic voiding disorders in humansQ73321320
Effect of estrogen on intracellular signaling pathways linked to activation of M(2)- and M(3)-muscarinic acetylcholine receptors in the rat myometriumQ73544814
Escherichia coli-induced inducible nitric oxide synthase and cyclooxygenase expression in the mouse bladder and kidneyQ73569333
P433issue8
P407language of work or nameEnglishQ1860
P304page(s)1659-1668
P577publication date2008-02-25
P1433published inBritish Journal of PharmacologyQ919631
P1476titleLong-term nitric oxide deficiency causes muscarinic supersensitivity and reduces beta(3)-adrenoceptor-mediated relaxation, causing rat detrusor overactivity
P478volume153

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cites work (P2860)
Q40114581Administration of BAY 41-2272 prevents bladder dysfunction in nitric-oxide deficient rats
Q36539976Association of insulin resistance with overactive bladder in female patients
Q54583146Characterization of the urinary bladder dysfunction in renovascular hypertensive rats.
Q85853632Does hypercholesterolemia affect the relaxation of the detrusor smooth muscle in rats? In vitro and in vivo studies
Q64114052Effect of co-administration of BRL-37344 and tadalafil on reduction of overactive bladder symptoms after induction of detrusor overactivity in mice1
Q52305623Effects of chronic administration of tamsulosin and tadalafil, alone or in combination, in rats with bladder outlet obstruction induced by chronic nitric oxide deficiency.
Q33692677Effects of nitric oxide inhibitors in mice with bladder outlet obstruction
Q35025867Human Urinary Bladder Strip Relaxation by the β-Adrenoceptor Agonist Isoprenaline: Methodological Considerations and Effects of Gender and Age.
Q37018672Increased bladder wall thickness in diabetic and nondiabetic women with overactive bladder
Q51277085Long-term treatment with the beta-3 adrenoceptor agonist, mirabegron ameliorates detrusor overactivity and restores cyclic adenosine monophosphate (cAMP) levels in obese mice.
Q90116976NO-releasing nanoparticles ameliorate detrusor overactivity in transgenic sickle cell mice via restored NO/ROCK signaling
Q37481272Preclinical compounds for the treatment of overactive bladder.
Q48508163Proteomic analysis of urothelium of rats with detrusor overactivity induced by bladder outlet obstruction.
Q47603923Stimulators and activators of soluble guanylate cyclase for urogenital disorders
Q44439706Urothelium-dependent and urothelium-independent detrusor contractility mediated by nitric oxide synthase and cyclooxygenase inhibition
Q48112211cAMP-dependent regulation of RhoA/Rho-kinase attenuates detrusor overactivity in a novel mouse experimental model.

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