A Direct Comparison of Metabolic Responses to High-Fat Diet in C57BL/6J and C57BL/6NJ Mice

scientific article published on 5 August 2016

A Direct Comparison of Metabolic Responses to High-Fat Diet in C57BL/6J and C57BL/6NJ Mice is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.2337/DB16-0291
P932PMC publication ID5079634
P698PubMed publication ID27495226

P2093author name stringP Darrell Neufer
Terence E Ryan
Maria J Torres
Kelsey H Fisher-Wellman
Laura A A Gilliam
Chien-Te Lin
Cody D Smith
Lauren R Reese
P2860cites workMispairing C57BL/6 substrains of genetically engineered mice and wild-type controls can lead to confounding results as it did in studies of JNK2 in acetaminophen and concanavalin A liver injuryQ24615237
Insulin resistance is a cellular antioxidant defense mechanismQ24650976
Attention to Background Strain Is Essential for Metabolic Research: C57BL/6 and the International Knockout Mouse ConsortiumQ26773196
Central nervous system control of food intake and body weightQ29619020
Reactive oxygen species have a causal role in multiple forms of insulin resistanceQ29619831
Protein Cysteines Map to Functional Networks According to Steady-state Level of OxidationQ30416903
A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strainsQ30436818
Diet-induced obesity in two C57BL/6 substrains with intact or mutant nicotinamide nucleotide transhydrogenase (Nnt) geneQ33925525
Analysis of GSH and GSSG after derivatization with N-ethylmaleimideQ34362782
Defective insulin secretory response to intravenous glucose in C57Bl/6J compared to C57Bl/6N miceQ34687550
Selective insulin resistance in adipocytesQ35560991
Defects in mitochondrial efficiency and H2O2 emissions in obese women are restored to a lean phenotype with aerobic exercise trainingQ35630850
A Comparative Study of the Metabolic and Skeletal Response of C57BL/6J and C57BL/6N Mice in a Diet-Induced Model of Type 2 DiabetesQ35749390
Increased reactive oxygen species production and lower abundance of complex I subunits and carnitine palmitoyltransferase 1B protein despite normal mitochondrial respiration in insulin-resistant human skeletal muscleQ35757202
Linking mitochondrial bioenergetics to insulin resistance via redox biologyQ35855378
Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cellsQ36165625
Behavioral differences among C57BL/6 substrains: implications for transgenic and knockout studies.Q36971705
Selective targeting of the cysteine proteome by thioredoxin and glutathione redox systems.Q37289421
Inhibiting myosin-ATPase reveals a dynamic range of mitochondrial respiratory control in skeletal muscle.Q37393404
Mitochondrial respiratory capacity and content are normal in young insulin-resistant obese humansQ37403358
Mitochondrial glutathione depletion reveals a novel role for the pyruvate dehydrogenase complex as a key H2O2-emitting source under conditions of nutrient overload.Q37662139
Nicotinamide nucleotide transhydrogenase: a key role in insulin secretionQ40332664
Pyruvate dehydrogenase complex and nicotinamide nucleotide transhydrogenase constitute an energy-consuming redox circuitQ41026815
Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humansQ42247172
Control of expression of insulin resistance and hyperglycemia by different genetic factors in diabetic C57BL/6J miceQ44016561
A genetic and physiological study of impaired glucose homeostasis control in C57BL/6J miceQ45281560
Diet-induced type II diabetes in C57BL/6J miceQ45730735
Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus.Q46588693
A spontaneous mutation in the nicotinamide nucleotide transhydrogenase gene of C57BL/6J mice results in mitochondrial redox abnormalities.Q46719392
Genetic modifiers of the phenotype of mice deficient in mitochondrial superoxide dismutaseQ46960424
Pathogenesis of pre-diabetes: mechanisms of fasting and postprandial hyperglycemia in people with impaired fasting glucose and/or impaired glucose tolerance.Q51484657
Genetic analysis of glucose tolerance in inbred mouse strains. Evidence for polygenic control.Q51625385
Impaired Akt phosphorylation in insulin-resistant human muscle is accompanied by selective and heterogeneous downstream defects.Q54454650
Determination of reduced and oxidized glutathione in biological samples using liquid chromatography with fluorimetric detectionQ57216716
Mouse strain-dependent variation in obesity and glucose homeostasis in response to high-fat feedingQ62888408
Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feedingQ63372079
Deletion of Nicotinamide Nucleotide Transhydrogenase: A New Quantitive Trait Locus Accounting for Glucose Intolerance in C57BL/6J MiceQ64355613
Mitochondrial transhydrogenase--a key enzyme in insulin secretion and, potentially, diabetesQ83965392
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)3249-3261
P577publication date2016-08-05
P1433published inDiabetesQ895262
P1476titleA Direct Comparison of Metabolic Responses to High-Fat Diet in C57BL/6J and C57BL/6NJ Mice
P478volume65

Reverse relations

cites work (P2860)
Q4772298717β-Estradiol Directly Lowers Mitochondrial Membrane Microviscosity and Improves Bioenergetic Function in Skeletal Muscle
Q55100432A Mouse Model of Beta-Cell Dysfunction as Seen in Human Type 2 Diabetes.
Q61446622A comparative analysis of hepatic pathological phenotypes in C57BL/6J and C57BL/6N mouse strains in non-alcoholic steatohepatitis models
Q49893263Absence of Nicotinamide Nucleotide Transhydrogenase in C57BL/6J Mice Exacerbates Experimental Atherosclerosis.
Q94453359Analysis of piRNA expression spectra in a non-alcoholic fatty liver disease mouse model induced by a methionine- and choline-deficient diet
Q91768020Association between high-fat diet feeding and male fertility in high reproductive performance mice
Q47106495Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a.
Q98611581C57BL/6J substrain differences in response to high-fat diet intervention
Q52582444Characterization and utilization of the flexor digitorum brevis for assessing skeletal muscle function.
Q99572053DR3 stimulation of adipose resident ILC2s ameliorates type 2 diabetes mellitus
Q92537632Decreases in Circulating Concentrations of Long-Chain Acylcarnitines and Free Fatty Acids During the Glucose Tolerance Test Represent Tissue-Specific Insulin Sensitivity
Q89993262Effect of Tff3 Deficiency and ER Stress in the Liver
Q48323438Genetics of metabolic syndrome: potential clues from wild-derived inbred mouse strains
Q90714029High fat diet aggravates cardiomyopathy in murine chronic Chagas disease
Q38991110High fat feeding unmasks variable insulin responses in male C57BL/6 mouse substrains
Q90400070Influence of Social Isolation During Prolonged Simulated Weightlessness by Hindlimb Unloading
Q38670980Loss of sirtuin 4 leads to elevated glucose- and leucine-stimulated insulin levels and accelerated age-induced insulin resistance in multiple murine genetic backgrounds.
Q48249334Manifestations and mechanisms of myocardial lipotoxicity in obesity.
Q58735419Mitochondrial - nuclear genetic interaction modulates whole body metabolism, adiposity and gene expression in vivo
Q90660624Mylk3 null C57BL/6N mice develop cardiomyopathy, whereas Nnt null C57BL/6J mice do not
Q33726651NNT reverse mode of operation mediates glucose control of mitochondrial NADPH and glutathione redox state in mouse pancreatic β-cells
Q92000262Neuronal growth regulator 1-deficient mice show increased adiposity and decreased muscle mass
Q90075126Obesity, Neuroinflammation, and Reproductive Function
Q88891926Remodeling of skeletal muscle mitochondrial proteome with high-fat diet involves greater changes to β-oxidation than electron transfer proteins in mice
Q92473034Response of Liver Metabolic Pathways to Ketogenic Diet and Exercise Are Not Additive
Q38656373Single-Subject Studies in Translational Nutrition Research.

Search more.