Generation of a tamoxifen inducible SMN mouse for temporal SMN replacement

scientific article published on 24 August 2011

Generation of a tamoxifen inducible SMN mouse for temporal SMN replacement is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/DVG.20764
P698PubMed publication ID21538807
P5875ResearchGate publication ID51094757

P2093author name stringDawn S Chandler
Thomas W Bebee
Jordan T Gladman
P2860cites workNeuronal SMN expression corrects spinal muscular atrophy in severe SMA mice while muscle-specific SMN expression has no phenotypic effectQ39521045
Kinetics of tamoxifen-regulated Cre activity in mice using a cartilage-specific CreER(T) to assay temporal activity windows along the proximodistal limb skeletonQ40300014
Disruption of an SF2/ASF-dependent exonic splicing enhancer in SMN2 causes spinal muscular atrophy in the absence of SMN1.Q40741164
Correlation between severity and SMN protein level in spinal muscular atrophyQ41102726
RETRACTED ARTICLE: Rescue of the spinal muscular atrophy phenotype in a mouse model by early postnatal delivery of SMNQ41275236
The human centromeric survival motor neuron gene (SMN2) rescues embryonic lethality in Smn(-/-) mice and results in a mouse with spinal muscular atrophyQ43569750
Systemic delivery of scAAV9 expressing SMN prolongs survival in a model of spinal muscular atrophyQ44329621
Nestin-CreER mice reveal DNA synthesis by nonapoptotic neurons following cerebral ischemia hypoxia.Q48295231
Z/AP, a double reporter for cre-mediated recombination.Q52178130
A negative element in SMN2 exon 7 inhibits splicing in spinal muscular atrophyQ73588971
The role of the SMN gene in proximal spinal muscular atrophyQ77293422
Effects of 2,4-diaminoquinazoline derivatives on SMN expression and phenotype in a mouse model for spinal muscular atrophyQ30492560
CNS-targeted gene therapy improves survival and motor function in a mouse model of spinal muscular atrophyQ30493891
Antisense correction of SMN2 splicing in the CNS rescues necrosis in a type III SMA mouse modelQ34030144
Splicing of the Survival Motor Neuron genes and implications for treatment of SMAQ34065993
Reduced survival of motor neuron (SMN) protein in motor neuronal progenitors functions cell autonomously to cause spinal muscular atrophy in model mice expressing the human centromeric (SMN2) geneQ34152015
Tetracyclines that promote SMN2 exon 7 splicing as therapeutics for spinal muscular atrophyQ34616822
Knockdown of the survival motor neuron (Smn) protein in zebrafish causes defects in motor axon outgrowth and pathfinding.Q35567371
Inactivation of the survival motor neuron gene, a candidate gene for human spinal muscular atrophy, leads to massive cell death in early mouse embryosQ36578997
Relationships between stem cell exhaustion, tumour suppression and ageingQ36611480
Inducible Cre recombinase activity in mouse mature astrocytes and adult neural precursor cellsQ36848828
A SMNDelta7 read-through product confers functionality to the SMNDelta7 proteinQ36861999
Spinal muscular atrophy: clinical classification and disease heterogeneityQ36924707
Detection of human survival motor neuron (SMN) protein in mice containing the SMN2 transgene: applicability to preclinical therapy development for spinal muscular atrophyQ37035709
A mouse model for spinal muscular atrophyQ38316939
P433issue12
P921main subjecttamoxifenQ412178
P304page(s)927-934
P577publication date2011-08-24
P1433published inGenesisQ5532784
P1476titleGeneration of a tamoxifen inducible SMN mouse for temporal SMN replacement
P478volume49