A low-toxicity IL-2-based immunocytokine retains antitumor activity despite its high degree of IL-2 receptor selectivity

scientific article published on 29 April 2011

A low-toxicity IL-2-based immunocytokine retains antitumor activity despite its high degree of IL-2 receptor selectivity is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1158/1078-0432.CCR-10-2921
P698PubMed publication ID21531812

P2093author name stringYaping Sun
Yan Lan
Stephen D Gillies
Kin-Ming Lo
Stefan O Mueller
Thore Hettmann
Beatrice Brunkhorst
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)3673-3685
P577publication date2011-04-29
P1433published inClinical Cancer ResearchQ332253
P1476titleA low-toxicity IL-2-based immunocytokine retains antitumor activity despite its high degree of IL-2 receptor selectivity
P478volume17

Reverse relations

cites work (P2860)
Q92965479A next-generation tumor-targeting IL-2 preferentially promotes tumor-infiltrating CD8+ T-cell response and effective tumor control
Q35266959An artificial antigen-presenting cell with paracrine delivery of IL-2 impacts the magnitude and direction of the T cell response.
Q60949713Anti-cancer Therapies Employing IL-2 Cytokine Tumor Targeting: Contribution of Innate, Adaptive and Immunosuppressive Cells in the Anti-tumor Efficacy
Q51786117Antibody-cytokine fusion proteins for cancer immunotherapy: an update on recent developments.
Q93129949Antibody-cytokine fusion proteins: A novel class of biopharmaceuticals for the therapy of cancer and of chronic inflammation
Q35212575Antigen specificity can be irrelevant to immunocytokine efficacy and biodistribution
Q55316979Beyond checkpoint inhibition - Immunotherapeutical strategies in combination with radiation.
Q37741534Cergutuzumab amunaleukin (CEA-IL2v), a CEA-targeted IL-2 variant-based immunocytokine for combination cancer immunotherapy: Overcoming limitations of aldesleukin and conventional IL-2-based immunocytokines.
Q33811204Challenges and developing solutions for increasing the benefits of IL-2 treatment in tumor therapy
Q36696647Combination delivery of TGF-β inhibitor and IL-2 by nanoscale liposomal polymeric gels enhances tumour immunotherapy
Q37637949Current and Potential Uses of Immunocytokines as Cancer Immunotherapy
Q96303542Cytokines that target immune killer cells against tumors
Q38017203Designing immunoconjugates for cancer therapy
Q61443377Directed evolution of super-secreted variants from phage-displayed human Interleukin-2
Q57911948Emerging classes of armed antibody therapeutics against cancer
Q55162750Flexible Macromolecule versus Rigid Particle Retention in the Injected Skin and Accumulation in Draining Lymph Nodes Are Differentially Influenced by Hydrodynamic Size.
Q91868537Human and murine IL2 receptors differentially respond to the human-IL2 component of immunocytokines
Q57911975Immunocytokines
Q28066935Immunocytokines and bispecific antibodies: two complementary strategies for the selective activation of immune cells at the tumor site
Q38132742Immunocytokines: a review of molecules in clinical development for cancer therapy
Q50034069Interleukin-2: Old and New Approaches to Enhance Immune-Therapeutic Efficacy
Q35059990NHS-IL2 combined with radiotherapy: preclinical rationale and phase Ib trial results in metastatic non-small cell lung cancer following first-line chemotherapy
Q64927862Radiotherapy in Combination With Cytokine Treatment.
Q38904873Synergistic immunologic targets for the treatment of prostate cancer
Q36552580T-cell activation by treatment of cancer patients with EMD 521873 (Selectikine), an IL-2/anti-DNA fusion protein
Q90382339Targeting tumor cells with antibodies enhances anti-tumor immunity
Q37900640The role of inflammation in the pathogenesis of lung cancer
Q44703429Tumor necrosis therapy antibody interleukin-2 fusion protein elicits prolonged and targeted antitumor effects in vivo
Q38014920Using antibodies to target cancer therapeutics

Search more.