Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor

scientific article published on 12 April 2011

Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor is …
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P6179Dimensions Publication ID1045231997
P356DOI10.1038/MP.2011.26
P8608Fatcat IDrelease_5eyvz3ruuzg57dpcjwyx6krc6u
P932PMC publication ID3121947
P698PubMed publication ID21483429
P5875ResearchGate publication ID51042194

P50authorSandrine ThuretQ23782729
Annamaria CattaneoQ37830437
Jack PriceQ52280420
P2093author name stringP A Zunszain
C M Pariante
L A Carvalho
M J Garabedian
C Anacker
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Antidepressants, beta-arrestins and GRKs: from regulation of signal desensitization to intracellular multifunctional adaptor functionsQ28244933
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Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatmentQ28295248
Antidepressants enhance glucocorticoid receptor function in vitro by modulating the membrane steroid transportersQ28363795
Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathwayQ28776004
Requirement of hippocampal neurogenesis for the behavioral effects of antidepressantsQ29547516
Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysisQ29619093
Chronic antidepressant treatment increases neurogenesis in adult rat hippocampusQ29619400
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Knockdown of brain-derived neurotrophic factor in specific brain sites precipitates behaviors associated with depression and reduces neurogenesis.Q30493524
Environmental enrichment requires adult neurogenesis to facilitate the recovery from psychosocial stressQ30497444
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p21Cip1 restricts neuronal proliferation in the subgranular zone of the dentate gyrus of the hippocampusQ36446238
Glycogen synthase kinase 3beta-mediated serine phosphorylation of the human glucocorticoid receptor redirects gene expression profiles.Q36994922
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Glucocorticoid receptor phosphorylation differentially affects target gene expressionQ37302402
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Effect of chronic antidepressant treatment on transcription factor binding activity in rat hippocampus and frontal cortexQ38333918
Cell cycle inhibition by FoxO forkhead transcription factors involves downregulation of cyclin D.Q39677789
Antidepressants increase β-arrestin 2 ubiquitinylation and degradation by the proteasomal pathway in C6 rat glioma cellsQ39765478
Time-dependent activation of Phox2a by the cyclic AMP pathway modulates onset and duration of p27Kip1 transcriptionQ39831318
De-phosphorylation of GR at Ser203 in nuclei associates with GR nuclear translocation and GLUT5 gene expression in Caco-2 cellsQ39990483
Antidepressants and antipsychotic drugs colocalize with 5-HT3 receptors in raft-like domains.Q40355189
Chronic antidepressant treatment prevents accumulation of gsalpha in cholesterol-rich, cytoskeletal-associated, plasma membrane domains (lipid rafts).Q40455521
Differential effects of antidepressants on glucocorticoid receptors in human primary blood cells and human monocytic U-937 cellsQ40661639
The phosphodiesterase type 4 inhibitor, rolipram, enhances glucocorticoid receptor functionQ40685855
Steroid-independent translocation of the glucocorticoid receptor by the antidepressant desipramineQ41088014
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Modulation of glucocorticoid receptor function by protein kinase A.Q41605052
Antidepressant fluoxetine enhances glucocorticoid receptor function in vitro by modulating membrane steroid transportersQ41947488
The antidepressant desipramine requires the ABCB1 (Mdr1)-type p-glycoprotein to upregulate the glucocorticoid receptor in miceQ42171425
Characterization and functional significance of glucocorticoid receptors in patients with major depression: modulation by antidepressant treatmentQ42440623
Kinetics of glucocorticoid receptor phosphorylation in intact cells. Evidence for hormone-induced hyperphosphorylation after activation and recycling of hyperphosphorylated receptorsQ42510862
Impact of lipid raft integrity on 5-HT3 receptor function and its modulation by antidepressants.Q42682344
Neurogenic effects of fluoxetine are attenuated in p11 (S100A10) knockout miceQ43130558
Short-term administration of fluoxetine and venlafaxine decreases corticosteroid receptor mRNA expression in the rat hippocampusQ43640160
Chronic treatment with the antidepressant amitriptyline prevents impairments in water maze learning in aging rats.Q43890700
Deciphering the phosphorylation "code" of the glucocorticoid receptor in vivoQ43986658
Differential regulation of corticosteroid receptors by monoamine neurotransmitters and antidepressant drugs in primary hippocampal cultureQ44430635
The antidepressant clomipramine regulates cortisol intracellular concentrations and glucocorticoid receptor expression in fibroblasts and rat primary neuronesQ44464123
The mood-improving actions of antidepressants do not depend on neurogenesis but are associated with neuronal remodeling.Q46266275
Drug-dependent requirement of hippocampal neurogenesis in a model of depression and of antidepressant reversalQ46649293
Chronic fluoxetine stimulates maturation and synaptic plasticity of adult-born hippocampal granule cells.Q46767739
Chronic fluoxetine treatment alters behavior, but not adult hippocampal neurogenesis, in BALB/cJ miceQ46802984
Stimulation of neurogenesis in the hippocampus of the adult rat by fluoxetine requires rhythmic change in corticosteroneQ46834052
Long-term treatment with antidepressants increases glucocorticoid receptor binding and gene expression in cultured rat hippocampal neuronesQ48091332
Regulation of glucocorticoid receptor-mRNA in human blood cells by amitriptyline and dexamethasoneQ48164425
Decreased numbers of progenitor cells but no response to antidepressant drugs in the hippocampus of elderly depressed patientsQ48317806
Chronic amitriptyline treatment induces hippocampal NGFI-A, glucocorticoid receptor and mineralocorticoid receptor mRNA expression in ratsQ48363729
Effect of brief corticosterone administration on SGK1 and RGS4 mRNA expression in rat hippocampus.Q48389435
Mesenchymal stem cells increase hippocampal neurogenesis and counteract depressive-like behaviorQ48423697
Differential effects of antidepressants on dexamethasone-induced nuclear translocation and expression of glucocorticoid receptor.Q48428036
Modulation of adult hippocampal neurogenesis by thyroid hormones: implications in depressive-like behaviorQ48667457
Adult hippocampal neurogenesis is involved in anxiety-related behaviorsQ48718504
A morphogenetic wave of p27Kip1 transcription directs cell cycle exit during organ of Corti development.Q52014319
Postmortem brain tissue of depressed suicides reveals increased Gs alpha localization in lipid raft domains where it is less likely to activate adenylyl cyclase.Q52585843
Antidepressants regulate glucocorticoid receptor messenger RNA concentrations in primary neuronal culturesQ69705215
The effect of long-term treatment with antidepressant drugs on the hippocampal mineralocorticoid and glucocorticoid receptors in ratsQ72684743
Mouse glucocorticoid receptor phosphorylation status influences multiple functions of the receptor proteinQ73182603
P4510describes a project that usesImageJQ1659584
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectneurogenesisQ1456827
P304page(s)738-750
P577publication date2011-04-12
P1433published inMolecular PsychiatryQ6895973
P1476titleAntidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor
P478volume16

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