Efficacy of the investigational echinocandin ASP9726 in a guinea pig model of invasive pulmonary aspergillosis

scientific article published on 9 March 2015

Efficacy of the investigational echinocandin ASP9726 in a guinea pig model of invasive pulmonary aspergillosis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/AAC.04857-14
P8608Fatcat IDrelease_ayjkrp6hwbbslcnjhz3dpcqofe
P932PMC publication ID4394786
P698PubMed publication ID25753643

P50authorNathan Paul WiederholdQ42104169
Thomas F PattersonQ56859142
Laura K. NajvarQ115923764
Rosie A BocanegraQ115923770
William R. KirkpatrickQ122227392
P2093author name stringBrian L Wickes
Satoru Matsumoto
Nathan P Wiederhold
Monica L Herrera
P2860cites workGenomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatusQ21972844
Isolation of Aspergillus spp. from the respiratory tract in critically ill patients: risk factors, clinical presentation and outcomeQ24811601
Antifungal efficacy, safety, and single-dose pharmacokinetics of LY303366, a novel echinocandin B, in experimental pulmonary aspergillosis in persistently neutropenic rabbitsQ28369150
Aspergillosis case-fatality rate: systematic review of the literatureQ31918085
Quantitative PCR assay to measure Aspergillus fumigatus burden in a murine model of disseminated aspergillosis: demonstration of efficacy of caspofungin acetateQ33983618
Micafungin versus caspofungin for treatment of candidemia and other forms of invasive candidiasisQ34006585
Antifungal efficacy of caspofungin (MK-0991) in experimental pulmonary aspergillosis in persistently neutropenic rabbits: pharmacokinetics, drug disposition, and relationship to galactomannan antigenemiaQ34104748
Anidulafungin versus fluconazole for invasive candidiasisQ34580316
Standardization of an experimental murine model of invasive pulmonary aspergillosisQ35091545
Identification of the FKS1 gene of Candida albicans as the essential target of 1,3-beta-D-glucan synthase inhibitors.Q35138937
The echinocandin antifungals: an overview of the pharmacology, spectrum and clinical efficacyQ35185757
Assessment of serum (1->3)-beta-D-glucan concentration as a measure of disease burden in a murine model of invasive pulmonary aspergillosis.Q36482821
Interlaboratory and interstudy reproducibility of a novel lateral-flow device and influence of antifungal therapy on detection of invasive pulmonary aspergillosis.Q36559047
Assessment of Aspergillus fumigatus burden in pulmonary tissue of guinea pigs by quantitative PCR, galactomannan enzyme immunoassay, and quantitative cultureQ36744831
Attenuation of echinocandin activity at elevated concentrations: a review of the paradoxical effect.Q36987908
Strain-dependent variation in 18S ribosomal DNA Copy numbers in Aspergillus fumigatusQ37191546
Paradoxical echinocandin activity: a limited in vitro phenomenon?Q37405284
Novel inhalational murine model of invasive pulmonary aspergillosisQ37734691
The antifungal echinocandin caspofungin acetate kills growing cells of Aspergillus fumigatus in vitroQ39652699
Synthesis and antifungal activity of ASP9726, a novel echinocandin with potent Aspergillus hyphal growth inhibitionQ42707146
Cyclophosphamide metabolism is affected by azole antifungalsQ43530745
Comparison of caspofungin and amphotericin B for invasive candidiasisQ44255071
Itraconazole versus fluconazole for prevention of fungal infections in patients receiving allogeneic stem cell transplantsQ44606439
Pharmacodynamics of caspofungin in a murine model of invasive pulmonary aspergillosis: evidence of concentration-dependent activityQ45066131
Combination antifungal therapy for invasive aspergillosisQ45096994
Efficacy and safety of caspofungin for treatment of invasive aspergillosis in patients refractory to or intolerant of conventional antifungal therapyQ45172488
Micafungin alone or in combination with other systemic antifungal therapies in hematopoietic stem cell transplant recipients with invasive aspergillosisQ46265389
Micafungin (FK463), alone or in combination with other systemic antifungal agents, for the treatment of acute invasive aspergillosis.Q51187346
Development of two real-time quantitative TaqMan PCR assays to detect circulating Aspergillus fumigatus DNA in serumQ56838501
Micafungin versus liposomal amphotericin B for candidaemia and invasive candidosis: a phase III randomised double-blind trialQ56970523
Invasive aspergillosis in critically ill patients without malignancyQ80269940
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectaspergillosisQ259626
P1104number of pages7
P304page(s)2875-2881
P577publication date2015-03-09
P1433published inAntimicrobial Agents and ChemotherapyQ578004
P1476titleEfficacy of the investigational echinocandin ASP9726 in a guinea pig model of invasive pulmonary aspergillosis
P478volume59

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Q37344546A complex game of hide and seek: the search for new antifungals
Q97525325Caenorhabditis elegans-Based Aspergillus fumigatus Infection Model for Evaluating Pathogenicity and Drug Efficacy
Q92575576Extended-Interval Dosing of Rezafungin against Azole-Resistant Aspergillus fumigatus
Q92970856In vitro and in vivo Efficacy of a Synergistic Combination of Itraconazole and Verapamil Against Aspergillus fumigatus
Q55511181Methodologies for in vitro and in vivo evaluation of efficacy of antifungal and antibiofilm agents and surface coatings against fungal biofilms.
Q33689767Rodent Models of Invasive Aspergillosis due to Aspergillus fumigatus: Still a Long Path toward Standardization.
Q38796140Systemic Antifungal Agents: Current Status and Projected Future Developments.

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