Antitumor activity and drug interactions of proteasome inhibitor Bortezomib in human high-risk myelodysplastic syndrome cells

scientific article published on 31 March 2011

Antitumor activity and drug interactions of proteasome inhibitor Bortezomib in human high-risk myelodysplastic syndrome cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S12185-011-0821-Z
P8608Fatcat IDrelease_t3apkqiqc5hibcqtpqenstolku
P698PubMed publication ID21451957
P5875ResearchGate publication ID50937349

P2093author name stringHui Liu
Jian Huang
Xin Sun
Jie Jin
Min Yang
Ting Ding
P2860cites workAddressing reported pro-apoptotic functions of NF-kappaB: targeted inhibition of canonical NF-kappaB enhances the apoptotic effects of doxorubicinQ28476078
Activators and target genes of Rel/NF-kappaB transcription factorsQ29547882
A Proteasome Inhibitor, Bortezomib, Inhibits Breast Cancer Growth and Reduces Osteolysis by Downregulating Metastatic GenesQ34203659
NF-kappaB and FLIP in arsenic trioxide (ATO)-induced apoptosis in myelodysplastic syndromes (MDSs)Q34560200
Proteasome inhibitors in the treatment of multiple myelomaQ34611676
The World Health Organization (WHO) classification of tumors of the hematopoietic and lymphoid tissues: an overview with emphasis on the myeloid neoplasmsQ35009549
Apoptosis defects and chemotherapy resistance: molecular interaction maps and networksQ35743146
The role of proteasome inhibitors in solid tumorsQ35821596
Nuclear factor-kappaB inhibitors as sensitizers to anticancer drugsQ36085634
Infliximab chimeric antitumor necrosis factor-a monoclonal antibody as potential treatment for myelodysplastic syndromes.Q36194610
The proteasome as a potential target for novel anticancer drugs and chemosensitizersQ36695969
Apoptosis and antiapoptotic mechanisms in the progression of myelodysplastic syndromeQ36988558
Proteasome inhibitors: a therapeutic strategy for haematological malignancyQ37175286
Novel therapies for relapsed myelomaQ37653290
Targeting transcription factor NF-kappaB to overcome chemoresistance and radioresistance in cancer therapy.Q37676478
Proteasome system of protein degradation and processingQ37704419
The development and pharmacology of proteasome inhibitors for the management and treatment of cancerQ37709559
An inducible pathway for degradation of FLIP protein sensitizes tumor cells to TRAIL-induced apoptosisQ38290395
Bcl-2 changes conformation to inhibit Bax oligomerizationQ40287064
NF-kappaB constitutes a potential therapeutic target in high-risk myelodysplastic syndromeQ40362293
The fully human anti-CD30 antibody 5F11 activates NF-{kappa}B and sensitizes lymphoma cells to bortezomib-induced apoptosisQ40425646
Inducible nuclear factor-kappaB activation contributes to chemotherapy resistance in gastric cancerQ40531487
In vitro culture studies of childhood myelodysplastic syndrome: establishment of the cell line MUTZ-1.Q41117851
Death receptor-induced signaling pathways are differentially regulated by gamma interferon upstream of caspase 8 processingQ42141887
Akt associates with nuclear factor kappaB and plays an important role in chemoresistance of gastric cancer cellsQ43049489
Sensitization of neuroblastoma cells for TRAIL-induced apoptosis by NF-kappaB inhibitionQ44057694
The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applicationsQ44211035
Mechanism of cytosine arabinoside-mediated apoptosis: role of Rel A (p65) dephosphorylationQ44508743
Inhibition of inducible NF-kappaB activity reduces chemoresistance to 5-fluorouracil in human stomach cancer cell lineQ44563849
Frequent elevation of Akt kinase phosphorylation in blood marrow and peripheral blood mononuclear cells from high-risk myelodysplastic syndrome patientsQ46845164
World Health Organization classification in combination with cytogenetic markers improves the prognostic stratification of patients with de novo primary myelodysplastic syndromes.Q53561569
Myelodysplastic SyndromesQ56639444
Nuclear factor k B is activated in myelodysplastic bone marrow cellsQ74753350
Myelodysplastic syndromesQ82442488
Stress-induced in vitro apoptosis of native human acute myelogenous leukemia (AML) cells shows a wide variation between patients and is associated with low BCL-2:Bax ratio and low levels of heat shock protein 70 and 90Q83115248
Proteasome inhibitor bortezomib targeted tumor-endothelial cell interaction in T-cell leukemia/lymphomaQ84550995
P433issue4
P921main subjectmyelodysplastic syndromeQ954625
P304page(s)482-493
P577publication date2011-03-31
P1433published inInternational Journal of HematologyQ6051416
P1476titleAntitumor activity and drug interactions of proteasome inhibitor Bortezomib in human high-risk myelodysplastic syndrome cells
P478volume93

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cites work (P2860)
Q39145987Functional exploration of colorectal cancer genomes using Drosophila
Q37031282Heat Shock Protein 90 is overexpressed in high-risk myelodysplastic syndromes and associated with higher expression and activation of Focal Adhesion Kinase
Q64240643Inhibition of the PI3K/AKT signaling pathway sensitizes diffuse large B-cell lymphoma cells to treatment with proteasome inhibitors via suppression of BAG3
Q35114769Reversal of bortezomib resistance in myelodysplastic syndrome cells by MAPK inhibitors
Q38821561Synergistic Effect and Molecular Mechanism of Homoharringtonine and Bortezomib on SKM-1 Cell Apoptosis

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