Improving the anti-diabetic activity of GLP-1 by fusion with globular adiponectin

scientific article published on August 14, 2012

Improving the anti-diabetic activity of GLP-1 by fusion with globular adiponectin is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3109/10731199.2012.712042
P953full work available at URLhttp://www.tandfonline.com/doi/pdf/10.3109/10731199.2012.712042
P698PubMed publication ID22889326

P2093author name stringWen Li
Xiangdong Gao
Yue Tong
Wenbing Yao
Mingming Gao
P2860cites workIncreasing the homogeneity, stability and activity of human serum albumin and interferon-alpha2b fusion protein by linker engineeringQ47653735
The effects of LY2189265, a long-acting glucagon-like peptide-1 analogue, in a randomized, placebo-controlled, double-blind study of overweight/obese patients with type 2 diabetes: the EGO studyQ51381364
Long-lasting antidiabetic effect of a dipeptidyl peptidase IV-resistant analog of glucagon-like peptide-1.Q51565136
Biological activity of GLP-1-analogues with N-terminal modificationsQ74665094
Evaluation of therapeutic potentials of site-specific PEGylated glucagon-like peptide-1 isomers as a type 2 anti-diabetic treatment: Insulinotropic activity, glucose-stabilizing capability, and proteolytic stabilityQ79283090
Production and purification of an analog of glucagon-like peptide-1 by auto-induction and on-column cleavage in Escherichia coliQ115771126
The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetesQ28273497
PEGylation, successful approach to drug deliveryQ28278538
The Physiology of Glucagon-like Peptide 1Q28373115
Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic ratsQ28578709
Biology of incretins: GLP-1 and GIPQ29617302
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndromeQ29619211
Transferrin fusion technology: a novel approach to prolonging biological half-life of insulinotropic peptidesQ34128861
A recombinant human glucagon-like peptide (GLP)-1-albumin protein (albugon) mimics peptidergic activation of GLP-1 receptor-dependent pathways coupled with satiety, gastrointestinal motility, and glucose homeostasis.Q34343581
Multiple low-dose streptozotocin-induced diabetes in the mouse. Evidence for stimulation of a cytotoxic cellular immune response against an insulin-producing beta cell lineQ34613096
Incretin mimetics and DPP-IV inhibitors for the treatment of type 2 diabetesQ36129110
Glycaemic variability and complications in patients with diabetes mellitus: evidence from a systematic review of the literatureQ37728075
The long-acting GLP-1 derivative NN2211 ameliorates glycemia and increases beta-cell mass in diabetic miceQ38363214
Prevalence of diabetes among men and women in ChinaQ39605920
Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications fpr metabolic regulation and bioactivityQ40681900
Expression, purification, and C-terminal site-specific PEGylation of cysteine-mutated glucagon-like peptide-1.Q43281505
Intein-mediated expression and purification of an analog of glucagon-like peptide-1 in Escherichia coliQ45326844
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)159-164
P577publication date2012-08-14
P1433published inArtificial cells, nanomedicine, and biotechnologyQ27724536
P1476titleImproving the anti-diabetic activity of GLP-1 by fusion with globular adiponectin
P478volume41

Reverse relations

cites work (P2860)
Q54217913Alleviation of high-fat diet-induced atherosclerosis and glucose intolerance by a novel GLP-1 fusion protein in ApoE(-/-) mice
Q38829746The promises and challenges of fusion constructs in protein biochemistry and enzymology.

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