The teratogenic potencies of valproic acid derivatives and their effects on biological end-points are related to changes in histone deacetylase and Erk1/2 activities.

scientific article published on 18 April 2011

The teratogenic potencies of valproic acid derivatives and their effects on biological end-points are related to changes in histone deacetylase and Erk1/2 activities. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/J.1742-7843.2011.00702.X
P698PubMed publication ID21439023
P5875ResearchGate publication ID50865518

P50authorPeter Schledermann WalmodQ42691154
Kamil GotfrydQ47156173
P2093author name stringElisabeth Bock
Vladimir Berezin
Heinz Nau
Maria Hansen
Anna Kawa
Ursula Ellerbeck
P2860cites workNovel histone deacetylase inhibitors in clinical trials as anti-cancer agentsQ21198868
Glycogen synthase kinase 3: more than a namesakeQ24315635
Valproate administered after traumatic brain injury provides neuroprotection and improves cognitive function in ratsQ27324438
The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transitionQ28301955
Valproic acid-induced spina bifida: a mouse modelQ28316245
Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cellsQ28366303
The mood stabilizers valproic acid and lithium enhance mesenchymal stem cell migration via distinct mechanismsQ28568768
Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogenQ29616224
HDAC6 modulates cell motility by altering the acetylation level of cortactinQ30439626
Valproate attenuates accelerated atherosclerosis in hyperglycemic apoE-deficient mice: evidence in support of a role for endoplasmic reticulum stress and glycogen synthase kinase-3 in lesion development and hepatic steatosisQ30485641
Cell type-specific anti-cancer properties of valproic acid: independent effects on HDAC activity and Erk1/2 phosphorylationQ30495932
Automated in vitro screening of teratogensQ31062094
Discriminative power of an assay for automated in vitro screening of teratogensQ33202681
MAP kinases and cell migrationQ35889220
GSK-3 is a viable potential target for therapeutic intervention in bipolar disorderQ36062876
Valproic acid as anti-cancer drug.Q37018024
Histone deacetylase inhibitors: mechanisms of cell death and promise in combination cancer therapyQ37156986
Inhibition of histone deacetylases: a pharmacological approach to the treatment of non-cancer disorders.Q37438513
What is the relative value of the standard anticonvulsants: Phenytoin and fosphenytoin, phenobarbital, valproate, and levetiracetam?Q37639437
The mood stabilizer valproic acid activates mitogen-activated protein kinases and promotes neurite growthQ38299684
Valproic acid enhances protein L-isoaspartyl methyltransferase expression by stimulating extracellular signal-regulated kinase signaling pathwayQ39860255
Differential effects of valproic acid on growth, proliferation and metastasis in HTB5 and HTB9 bladder cancer cell linesQ39867753
Valproic acid inhibits Abeta production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse modelsQ39924456
Epigenetic reprogramming of breast cancer cells by valproic acid occurs regardless of estrogen receptor status.Q39940410
Valproic acid enhances tubulin acetylation and apoptotic activity of paclitaxel on anaplastic thyroid cancer cell lines.Q40072387
Valproic acid inhibits invasiveness in bladder cancer but not in prostate cancer cellsQ40251579
Valproate protects cells from ER stress-induced lipid accumulation and apoptosis by inhibiting glycogen synthase kinase-3.Q40483325
The mood-stabilizing agent valproate inhibits the activity of glycogen synthase kinase-3.Q40970988
Anticonvulsant and neurotoxic activities of twelve analogues of valproic acidQ42287628
Further branching of valproate-related carboxylic acids reduces the teratogenic activity, but not the anticonvulsant effectQ42553750
The anticonvulsant sodium valproate specifically induces the expression of a rat glial heat shock protein which is identified as the collagen type IV receptorQ42802803
Histone deacetylase inhibitors decrease proliferation potential and multilineage differentiation capability of human mesenchymal stem cellsQ43290186
Valproate regulates GSK-3-mediated axonal remodeling and synapsin I clustering in developing neuronsQ44047015
Increased human cytomegalovirus replication in fibroblasts after treatment with therapeutical plasma concentrations of valproic acidQ44970276
Examining the correlations between GSK-3 inhibitory properties and anti-convulsant efficacy of valproate and valproate-related compoundsQ45105674
Ras/MAP kinase pathways are involved in Ras specific apoptosis induced by sodium butyrateQ46566506
Valproic acid induces extracellular signal-regulated kinase 1/2 activation and inhibits apoptosis in endothelial cellsQ46706734
Teratogenic potency of valproate analogues evaluated by quantitative estimation of cellular morphology in vitroQ47792826
Multiple effects of pentyl-4-yn-VPA enantiomers: from toxicity to short-term memory enhancementQ48374878
Prediction of teratogenic potency of valproate analogues using cerebellar aggregation cultures.Q52196687
[Structural bases of the teratogenic effects of the antiepileptic valproic acid. 2-n-propyl-4-pentenic acid, the first structural analogue with significantly higher teratogenic action than VPA].Q53037356
Studies on the teratogen pharmacophore of valproic acid analogues: evidence of interactions at a hydrophobic centre.Q55477468
Correlation of in vitro anti-proliferative potential with in vivo teratogenicity in a series of valproate analogues.Q55478740
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectteratogenicityQ56246640
P304page(s)164-174
P577publication date2011-04-18
P1433published inBasic and Clinical Pharmacology and ToxicologyQ15724438
P1476titleThe teratogenic potencies of valproic acid derivatives and their effects on biological end-points are related to changes in histone deacetylase and Erk1/2 activities
P478volume109

Reverse relations

cites work (P2860)
Q55716842Antiepileptic drugs and pregnancy outcomes.
Q34113695Chromatin remodeling, cell proliferation and cell death in valproic acid-treated HeLa cells
Q44152775Enantioselective apoptosis induction in histiocytic lymphoma cells and acute promyelocytic leukemia cells
Q38040133Epigenetics of psychoactive drugs
Q39031044Induction of neurotrophic and differentiation factors in neural stem cells by valproic acid
Q34380256New perspectives of valproic acid in clinical practice.
Q38077730Prenatal exposures associated with neurodevelopmental delay and disabilities
Q40388690Valproic acid stimulates proliferation of glial precursors during cortical gliogenesis in developing rat.

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