UV irradiation induces the murine urokinase-type plasminogen activator gene via the c-Jun N-terminal kinase signaling pathway: requirement of an AP1 enhancer element.

scientific article published on August 1998

UV irradiation induces the murine urokinase-type plasminogen activator gene via the c-Jun N-terminal kinase signaling pathway: requirement of an AP1 enhancer element. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/MCB.18.8.4537
P932PMC publication ID109039
P698PubMed publication ID9671463

P50authorMaribel ParraQ42587739
Francesc MirallesQ73355193
P2093author name stringY Nagamine
P Muñoz-Cánoves
J Félez
C Caelles
P2860cites workJNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domainQ24308838
Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinaseQ24309889
A protein kinase involved in the regulation of inflammatory cytokine biosynthesisQ24311139
ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiationQ24312012
Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoformsQ24312029
Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2Q24313872
Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinasesQ24316962
A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stressQ24318293
Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta)Q24321919
Characterization of the structure and function of a novel MAP kinase kinase (MKK6)Q24336966
Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2Q24532154
A novel complex between the p65 subunit of NF-kappa B and c-Rel binds to a DNA element involved in the phorbol ester induction of the human urokinase geneQ24555708
Mxi2, a mitogen-activated protein kinase that recognizes and phosphorylates Max proteinQ24564025
ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agentsQ24568306
ATF-2 contains a phosphorylation-dependent transcriptional activation domainQ24568315
MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathwayQ24650627
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform ExtractionQ25938986
A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cellsQ28237789
Interaction between c-Rel and the mitogen-activated protein kinase kinase kinase 1 signaling cascade in mediating kappaB enhancer activationQ28277712
Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP KinaseQ28280649
Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonineQ28287650
Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathwayQ28302102
Transcription factor ATF2 regulation by the JNK signal transduction pathwayQ28305631
A synthetic inhibitor of the mitogen-activated protein kinase cascadeQ28367955
A cytoplasmic inhibitor of the JNK signal transduction pathwayQ28586970
Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38deltaQ28646538
Opposing effects of ERK and JNK-p38 MAP kinases on apoptosisQ29547567
The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathwayQ29614258
A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteinsQ29617438
The stress-activated protein kinase subfamily of c-Jun kinasesQ29620001
Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-JunQ29620103
Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domainQ29620169
The mitogen-activated protein kinase signal transduction pathwayQ29620226
Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKKQ29620274
SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1Q29620495
The plasminogen-plasmin system in malignancyQ35477781
The murine urokinase-type plasminogen activator geneQ36315021
Induction of plasminogen activator by UV light in normal and xeroderma pigmentosum fibroblastsQ36374667
c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinasesQ36667357
Rapid and preferential activation of the c-jun gene during the mammalian UV responseQ36693305
UV-induced DNA damage is an intermediate step in UV-induced expression of human immunodeficiency virus type 1, collagenase, c-fos, and metallothioneinQ36796267
SAP kinase-3, a new member of the family of mammalian stress-activated protein kinasesQ36833340
Induction of urokinase-type plasminogen activator by UV light in human fetal fibroblasts is mediated through a UV-induced secreted proteinQ36834791
Urokinase is required for the pulmonary inflammatory response to Cryptococcus neoformans. A murine transgenic modelQ37354110
Response to adversity: molecular control of gene activation following genotoxic stressQ37422748
Induction of c-fos expression through JNK-mediated TCF/Elk-1 phosphorylation.Q37625844
Urokinase-dependent cell surface proteolysis and cancerQ37868537
Plasminogen activators, tissue degradation, and cancerQ39476382
Immunology and photocarcinogenesis. New light on an old problemQ39477739
Cell-associated plasminogen activation: regulation and physiological functionsQ39607376
Inducible DNA repair systemsQ39826678
Cytoskeletal reorganization and TPA differently modify AP-1 to induce the urokinase-type plasminogen activator gene in LLC-PK1 cellsQ40519768
Transcription factor PEA3 participates in the induction of urokinase plasminogen activator transcription in murine keratinocytes stimulated with epidermal growth factor or phorbol-esterQ40523285
Initiation of acute phase response and synthesis of cytokinesQ40661106
Fos is an essential component of the mammalian UV responseQ40789823
UV-induced activation of AP-1 involves obligatory extranuclear steps including Raf-1 kinaseQ40872239
Proteolytic cleavage of the urokinase receptor substitutes for the agonist-induced chemotactic effectQ41064411
Differential regulation of urokinase-type plasminogen activator expression by basic fibroblast growth factor and serum in myogenesis. Requirement of a common mitogen-activated protein kinase pathwayQ41069903
Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agentsQ41077480
The p38 and ERK MAP kinase pathways cooperate to activate Ternary Complex Factors and c-fos transcription in response to UV light.Q41078766
Molecular cloning and characterization of a novel p38 mitogen-activated protein kinaseQ41091097
Cytoskeleton reorganization induces the urokinase-type plasminogen activator gene via the Ras/extracellular signal-regulated kinase (ERK) signaling pathwayQ41133919
Stimulation of urokinase expression by TNF-alpha requires the activation of binding sites for the AP-1 and PEA3 transcription factorsQ41324237
UV-induced signal transductionQ41356307
Ras-dependent activation of MAP kinase pathway mediated by G-protein beta gamma subunits.Q41461969
A regulatory element that mediates co-operation between a PEA3-AP-1 element and an AP-1 site is required for phorbol ester induction of urokinase enhancer activity in HepG2 hepatoma cellsQ41546059
Pulmonary epithelial cell urokinase-type plasminogen activator. Induction by interleukin-1 beta and tumor necrosis factor-alphaQ41620069
Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38)Q42609308
Regulation of the urokinase-type plasminogen activator gene by the oncogene Tpr-Met involves GRB2.Q42803782
jun-NH2-terminal kinase activation mediated by UV-induced DNA lesions in melanoma and fibroblast cells.Q42822966
Elucidation of a signaling pathway induced by FGF-2 leading to uPA gene expression in NIH 3T3 fibroblastsQ42825425
Induction and desensitization of plasminogen activator gene expression by tumor promotersQ43922815
NF-kappa B activation by ultraviolet light not dependent on a nuclear signal.Q45971622
The UV response involving the Ras signaling pathway and AP-1 transcription factors is conserved between yeast and mammalsQ46508406
The primary structure of p38 gamma: a new member of p38 group of MAP kinasesQ46763189
DNA repair and induction of plasminogen activator in human fetal cells treated with ultraviolet light.Q53553741
Physiological consequences of loss of plasminogen activator gene function in miceQ59069678
The mammalian ultraviolet response is triggered by activation of src tyrosine kinasesQ60621256
Endogenously produced urokinase amplifies tumor necrosis factor-alpha secretion by THP-1 mononuclear phagocytesQ71007584
Role for p38 mitogen-activated protein kinase in platelet aggregation caused by collagen or a thromboxane analogueQ71091459
Ultraviolet Irradiation, although It Activates the Transcription Factor AP-1 in F9 Teratocarcinoma Stem Cells, Does Not Induce the Full Complement of Differentiation-Associated GenesQ71645956
Heterodimerization of c-Jun with ATF-2 and c-Fos is required for positive and negative regulation of the human urokinase enhancerQ71928311
Activation of 12-O-tetradecanoylphorbol-13-acetate response element- and dyad symmetry element-dependent transcription by interleukin-5 is mediated by Jun N-terminal kinase/stress-activated protein kinase kinasesQ71985214
Involvement of growth factor receptors in the mammalian UVC responseQ72710815
Damage to DNA by UV light and activation of transcription factorsQ72781909
Inhibition of urokinase-type plasminogen activator (uPA) abrogates myogenesis in vitroQ73145823
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectplasminogenQ107129060
P304page(s)4537-4547
P577publication date1998-08-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleUV irradiation induces the murine urokinase-type plasminogen activator gene via the c-Jun N-terminal kinase signaling pathway: requirement of an AP1 enhancer element
P478volume18

Reverse relations

cites work (P2860)
Q37801943Characteristics of the level-of-evidence-1 disease forecast cancer biomarkers uPA and its inhibitor PAI-1.
Q38931511Characterization and mechanisms of photoageing-related changes in skin. Damages of basement membrane and dermal structures
Q39632834Curcumin Facilitates Fibrinolysis and Cellular Migration during Wound Healing by Modulating Urokinase Plasminogen Activator Expression
Q33687878Deregulation of the signaling pathways controlling urokinase production. Its relationship with the invasive phenotype.
Q40864626ERK signalling in metastatic human MDA-MB-231 breast carcinoma cells is adapted to obtain high urokinase expression and rapid cell proliferation
Q73832205Expression of urokinase plasminogen activator and receptor in conjunction with the ets family and AP-1 complex transcription factors in high grade prostate cancers
Q41504553Heparanase Inhibitors Facilitate the Assembly of the Basement Membrane in Artificial Skin
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Q46609756Plasmin induces degradation and dysfunction of laminin 332 (laminin 5) and impaired assembly of basement membrane at the dermal-epidermal junction.
Q37579011Possible involvement of basement membrane damage in skin photoaging
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Q40445624Role of Bak in UV-induced apoptosis in skin cancer and abrogation by HPV E6 proteins
Q38321462Role of distinct mitogen-activated protein kinase pathways and cooperation between Ets-2, ATF-2, and Jun family members in human urokinase-type plasminogen activator gene induction by interleukin-1 and tetradecanoyl phorbol acetate
Q42819230The p38 SAPK pathway is required for Ha-ras induced in vitro invasion of NIH3T3 cells
Q36127141The synthetic cannabinoid R(+)WIN55,212-2 augments interferon-β expression via peroxisome proliferator-activated receptor-α.
Q53754222U0126, a mitogen-activated protein kinase kinase inhibitor, inhibits the invasion of human A375 melanoma cells.
Q42502120Urokinase activity in corneal fibroblasts may be modulated by DNA damage and secreted proteins
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