Identification of regions of poliovirus 2BC protein that are involved in cytotoxicity

scientific article published on May 1998

Identification of regions of poliovirus 2BC protein that are involved in cytotoxicity is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/JVI.72.5.3560-3570.1998
P932PMC publication ID109576
P698PubMed publication ID9557636

P50authorAngel BarcoQ37387292
P2093author name stringL Carrasco
P2860cites workGuanidine-selected mutants of poliovirus: mapping of point mutations to polypeptide 2CQ27486796
Membrane permeabilization by poliovirus proteins 2B and 2BCQ71514738
Membrane rearrangement and vesicle induction by recombinant poliovirus 2C and 2BC in human cellsQ72011318
Amino terminal regions of poliovirus 2C protein mediate membrane bindingQ72230127
Overexpression of the ER-membrane protein P-450 CYP52A3 mimics sec mutant characteristics in Saccharomyces cerevisiaeQ72690069
The yeast Saccharomyces cerevisiae as a genetic system for obtaining variants of poliovirus protease 2AQ73316448
ELECTRON MICROSCOPIC STUDY OF THE FORMATION OF POLIOVIRUSQ78461728
Two nuclear mutations that block mitochondrial protein import in yeastQ29618080
Production of guanidine-resistant and -dependent poliovirus mutants from cloned cDNA: mutations in polypeptide 2C are directly responsible for altered guanidine sensitivityQ33929618
Modification of membrane permeability by animal viruses.Q34314053
Cellular origin and ultrastructure of membranes induced during poliovirus infectionQ35869390
Poliovirus protein 2BC increases cytosolic free calcium concentrationsQ35890568
Increased amounts of HMG-CoA reductase induce "karmellae": a proliferation of stacked membrane pairs surrounding the yeast nucleusQ36219042
Organelle assembly in yeast: characterization of yeast mutants defective in vacuolar biogenesis and protein sortingQ36219420
RNA duplex unwinding activity of poliovirus RNA-dependent RNA polymerase 3DpolQ36646719
Three poliovirus 2B mutants exhibit noncomplementable defects in viral RNA amplification and display dosage-dependent dominance over wild-type poliovirusQ36797358
An intragenic revertant of a poliovirus 2C mutant has an uncoating defectQ36802074
Structural organization of poliovirus RNA replication is mediated by viral proteins of the P2 genomic regionQ36802164
Guanidine-resistant mutants of poliovirus have distinct mutations in peptide 2C.Q36831256
Genetic complementation among poliovirus mutants derived from an infectious cDNA cloneQ36870660
Isolation of poliovirus 2C mutants defective in viral RNA synthesisQ36881372
Inhibition of cellular protein secretion by poliovirus proteins 2B and 3AQ37694671
Poliovirus translationQ37892780
Poliovirus protein 2C contains two regions involved in RNA binding activityQ38296289
Induction of membrane proliferation by poliovirus proteins 2C and 2BC.Q38299926
Biochemical studies on poliovirus polypeptide 2C: evidence for ATPase activityQ38311094
Poliovirus protein 2C has ATPase and GTPase activitiesQ38320145
Coxsackievirus protein 2B modifies endoplasmic reticulum membrane and plasma membrane permeability and facilitates virus release.Q39448952
Enhanced intracellular calcium concentration during poliovirus infection.Q39871328
Genetic analysis of a hydrophobic domain of coxsackie B3 virus protein 2B: a moderate degree of hydrophobicity is required for a cis-acting function in viral RNA synthesisQ39872703
Coxsackie B3 virus protein 2B contains cationic amphipathic helix that is required for viral RNA replication.Q39874721
Poliovirus infection and expression of the poliovirus protein 2B provoke the disassembly of the Golgi complex, the organelle target for the antipoliovirus drug Ro-090179.Q39879976
Membrane leakiness after viral infection and a new approach to the development of antiviral agentsQ40141845
The cytoskeletal framework and poliovirus metabolismQ40237083
A human virus protein, poliovirus protein 2BC, induces membrane proliferation and blocks the exocytic pathway in the yeast Saccharomyces cerevisiae.Q40788795
Functional compartments of the yeast Golgi apparatus are defined by the sec7 mutation.Q40819167
Brefeldin A reversibly blocks early but not late protein transport steps in the yeast secretory pathwayQ40872149
Phospholipid biosynthesis and poliovirus genome replication, two coupled phenomenaQ41215320
Kinetics and location of poliovirus macromolecular synthesis in correlation to virus-induced cytopathologyQ43587227
Structure-function analysis of coxsackie B3 virus protein 2B.Q45765129
Intracellular distribution of poliovirus proteins and the induction of virus-specific cytoplasmic structuresQ45797426
Association of polioviral proteins of the P2 genomic region with the viral replication complex and virus-induced membrane synthesis as visualized by electron microscopic immunocytochemistry and autoradiographyQ45842712
A new superfamily of putative NTP-binding domains encoded by genomes of small DNA and RNA virusesQ57845145
Enhancement of phospholipase activity during poliovirus infectionQ62637551
Membranous structures associated with translation and transcription of poliovirus RNAQ68600699
Modification of membrane permeability by animal virusesQ69206863
Compartmentalized assembly of oligosaccharides on exported glycoproteins in yeastQ70181188
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectcytotoxicityQ246181
PoliovirusQ70923324
P304page(s)3560-3570
P577publication date1998-05-01
P1433published inJournal of VirologyQ1251128
P1476titleIdentification of regions of poliovirus 2BC protein that are involved in cytotoxicity
P478volume72

Reverse relations

cites work (P2860)
Q27469472Amino Acid Changes in Proteins 2B and 3A Mediate Rhinovirus Type 39 Growth in Mouse Cells
Q34291480COPI is required for enterovirus 71 replication
Q39724199Cell permeabilization by poliovirus 2B viroporin triggers bystander permeabilization in neighbouring cells through a mechanism involving gap junctions.
Q34859664Changes in rhinovirus protein 2C allow efficient replication in mouse cells
Q39683772Cowpea mosaic virus 32- and 60-kilodalton replication proteins target and change the morphology of endoplasmic reticulum membranes.
Q33707361Effects of foot-and-mouth disease virus nonstructural proteins on the structure and function of the early secretory pathway: 2BC but not 3A blocks endoplasmic reticulum-to-Golgi transport
Q42424924Evidence for functional protein interactions required for poliovirus RNA replication
Q34464207Initiation of poliovirus negative-strand RNA synthesis requires precursor forms of p2 proteins
Q40062755Intracellular restriction of a productive noncytopathic coronavirus infection
Q35217970Mechanisms of membrane permeabilization by picornavirus 2B viroporin
Q38725275Membrane integration of poliovirus 2B viroporin.
Q27469717Membrane permeabilization by small hydrophobic nonstructural proteins of Japanese encephalitis virus.
Q47547322Organelle luminal dependence of (+)strand RNA virus replication reveals a hidden druggable target
Q33848147Poliovirus protein 3A inhibits tumor necrosis factor (TNF)-induced apoptosis by eliminating the TNF receptor from the cell surface
Q33788730Poliovirus proteins induce membrane association of GTPase ADP-ribosylation factor
Q35190954Recombination in enteroviruses is a biphasic replicative process involving the generation of greater-than genome length 'imprecise' intermediates
Q39606628Sindbis virus variant with a deletion in the 6K gene shows defects in glycoprotein processing and trafficking: lack of complementation by a wild-type 6K gene in trans.
Q40549200The transmembrane domain of hepatitis C virus E1 glycoprotein induces cell death.
Q39603635Viral protein U (Vpu)-mediated enhancement of human immunodeficiency virus type 1 particle release depends on the rate of cellular proliferation
Q34230206Viroporins.
Q38023155Viroporins: structure and biological functions.

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