Synthesis and preliminary evaluation of selected 2-aryl-5(6)-nitro- 1H-benzimidazole derivatives as potential anticancer agents

scientific article published on February 2011

Synthesis and preliminary evaluation of selected 2-aryl-5(6)-nitro- 1H-benzimidazole derivatives as potential anticancer agents is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S12272-011-0201-5
P698PubMed publication ID21380799
P5875ResearchGate publication ID50291375

P50authorGabriel Navarrete-VazquezQ60608017
P2093author name stringIsmael León-Rivera
Aurelio Romero-Castro
Alejandro Nieto-Rodríguez
Laura Citlalli Avila-Rojas
P2860cites workSynthesis, DNA-binding activity and cytotoxicity of carbamate derivatives of Hoechst 33258 in breast cancer MCF-7 cellsQ33183962
Prediction of biological activity spectra for substances: evaluation on the diverse sets of drug-like structures.Q35060982
Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitorsQ36111918
Chemopotentiation by PARP inhibitors in cancer therapy.Q36136079
A synthetic lethal therapeutic approach: poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repairQ37203855
Synthesis and SAR of novel, potent and orally bioavailable benzimidazole inhibitors of poly(ADP-ribose) polymerase (PARP) with a quaternary methylene-amino substituentQ39967222
Synthesis and anti-hepatitis B virus activity of novel benzimidazole derivativesQ40253656
Potentiation of cytotoxic drug activity in human tumour cell lines, by amine-substituted 2-arylbenzimidazole-4-carboxamide PARP-1 inhibitors.Q40562818
Novel poly(ADP-ribose) polymerase-1 inhibitor, AG14361, restores sensitivity to temozolomide in mismatch repair-deficient cells.Q40590684
Pyrrolobenzimidazoles linked to heterocycles and peptides. Design of DNA base pair specific phosphate hydrolyzing agents and novel cytotoxic agentsQ40603920
Effect of nitroreduction on the alkylating reactivity and cytotoxicity of the 2,4-dinitrobenzamide-5-aziridine CB 1954 and the corresponding nitrogen mustard SN 23862: distinct mechanisms of bioreductive activation.Q40654075
Synthesis and primary cytotoxicity evaluation of new 5-nitroindole-2,3-dione derivativesQ40688103
S phase and G2 arrests induced by topoisomerase I poisons are dependent on ATR kinase functionQ40769630
Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell linesQ41679901
Synthesis and potent antimicrobial activity of some novel methyl or ethyl 1H-benzimidazole-5-carboxylates derivatives carrying amide or amidine groupsQ45255810
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)181-189
P577publication date2011-02-01
P1433published inArchives of Pharmacal ResearchQ13557312
P1476titleSynthesis and preliminary evaluation of selected 2-aryl-5(6)-nitro- 1H-benzimidazole derivatives as potential anticancer agents
P478volume34

Reverse relations

cites work (P2860)
Q39329828Benzimidazole Scaffold as Anticancer Agent: Synthetic Approaches and Structure-Activity Relationship
Q50074746Design, synthesis and biological evaluation of chrysin benzimidazole derivatives as potential anticancer agents
Q39260501Microwave-assisted synthesis of sec/tert-butyl 2-arylbenzimidazoles and their unexpected antiproliferative activity towards ER negative breast cancer cells
Q38974799Synthesis and anticancer effects of some novel 2-(4-phenoxyphenyl)-1H-benzimidazole derivatives on K562 cell line.
Q39128810Synthesis and cytotoxic evaluation of novel N-substituted amidino-1-hydroxybenzimidazole derivatives
Q37209905Synthesis, Crystal Study, and Anti-Proliferative Activity of Some 2-Benzimidazolylthioacetophenones towards Triple-Negative Breast Cancer MDA-MB-468 Cells as Apoptosis-Inducing Agents.

Search more.