Dasatinib inhibits B cell receptor signalling in chronic lymphocytic leukaemia but novel combination approaches are required to overcome additional pro-survival microenvironmental signals

scientific article published on 24 February 2011

Dasatinib inhibits B cell receptor signalling in chronic lymphocytic leukaemia but novel combination approaches are required to overcome additional pro-survival microenvironmental signals is …
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scholarly articleQ13442814

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P356DOI10.1111/J.1365-2141.2010.08507.X
P698PubMed publication ID21352196
P5875ResearchGate publication ID50212008

P50authorAlison M MichieQ38321055
Emilio CosimoQ53114532
Alison M McCaigQ114443937
P2093author name stringMichael T Leach
P2860cites workChronic lymphocytic leukemiaQ28236621
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Tyrosine kinase inhibition in diffuse large B-cell lymphoma: molecular basis for antitumor activity and drug resistance of dasatinib.Q39965971
The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cellsQ40069478
A sustained activation of PI3K/NF-kappaB pathway is critical for the survival of chronic lymphocytic leukemia B cells.Q40549559
Inhibition of constitutive and BCR-induced Syk activation downregulates Mcl-1 and induces apoptosis in chronic lymphocytic leukemia B cellsQ42446777
Activities of SYK and PLCgamma2 predict apoptotic response of CLL cells to SRC tyrosine kinase inhibitor dasatinib.Q43196182
Differential signaling via surface IgM is associated with VH gene mutational status and CD38 expression in chronic lymphocytic leukemiaQ44189675
Geldanamycin and herbimycin A induce apoptotic killing of B chronic lymphocytic leukemia cells and augment the cells' sensitivity to cytotoxic drugsQ44630309
Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays.Q45198729
The tyrosine kinase Syk regulates the survival of chronic lymphocytic leukemia B cells through PKCdelta and proteasome-dependent regulation of Mcl-1 expression.Q45937702
The novel nuclear factor-kappaB inhibitor LC-1 is equipotent in poor prognostic subsets of chronic lymphocytic leukemia and shows strong synergy with fludarabineQ46195227
c-Abl kinase inhibitors overcome CD40-mediated drug resistance in CLL: implications for therapeutic targeting of chemoresistant nichesQ46363638
The kinase inhibitor dasatinib induces apoptosis in chronic lymphocytic leukemia cells in vitro with preference for a subgroup of patients with unmutated IgVH genesQ46542604
Hsp90 inhibition has opposing effects on wild-type and mutant p53 and induces p21 expression and cytotoxicity irrespective of p53/ATM status in chronic lymphocytic leukaemia cellsQ46914766
Rituximab and 17-allylamino-17-demethoxygeldanamycin induce synergistic apoptosis in B-cell chronic lymphocytic leukaemiaQ46940974
CD154 induces a switch in pro-survival Bcl-2 family members in chronic lymphocytic leukaemia.Q53531377
Separate cell culture conditions to promote proliferation or quiescent cell survival in chronic lymphocytic leukemia.Q53534107
Survival response to B-cell receptor ligation is restricted to progressive chronic lymphocytic leukemia cells irrespective of Zap70 expression.Q53610680
c-Abl Expression in Chronic Lymphocytic Leukemia Cells: Clinical and Therapeutic ImplicationsQ57374736
Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemiaQ58042064
Dasatinib sensitizes primary chronic lymphocytic leukaemia lymphocytes to chlorambucil and fludarabinein vitroQ58436764
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectdasatinibQ419940
leukemiaQ29496
lymphocyteQ715347
chronic lymphocytic leukemiaQ1088156
dasatinib monohydrateQ27139135
P304page(s)199-211
P577publication date2011-02-24
P1433published inBritish Journal of HaematologyQ4970200
P1476titleDasatinib inhibits B cell receptor signalling in chronic lymphocytic leukaemia but novel combination approaches are required to overcome additional pro-survival microenvironmental signals
P478volume153