miR-125b targets DNMT3b and mediates p53 DNA methylation involving in the vascular smooth muscle cells proliferation induced by homocysteine

scientific article published on 14 July 2016

miR-125b targets DNMT3b and mediates p53 DNA methylation involving in the vascular smooth muscle cells proliferation induced by homocysteine is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.YEXCR.2016.07.007
P8608Fatcat IDrelease_2gvhyeytq5dytosf7e6hhd7ini
P698PubMed publication ID27426728

P2093author name stringLi Zhao
Hua Xu
Xiaoling Yang
Minghao Zhang
Xuebo Han
Guizhong Li
HuiPing Zhang
YiDeng Jiang
ChengJian Cao
Longxia Zhou
P2860cites workExpression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiationQ21194851
Matrix metalloproteinase-8 promotes vascular smooth muscle cell proliferation and neointima formation.Q53085280
p53 expression in human carotid atheroma is significantly related to plaque instability and clinical manifestations.Q53349571
Increased plasma S-adenosyl-homocysteine levels induce the proliferation and migration of VSMCs through an oxidative stress-ERK1/2 pathway in apoE(-/-) mice.Q54518174
TP53is frequently altered by methylation, mutation, and/or deletion in acute lymphoblastic leukaemiaQ61882507
Hyperhomocysteinemia: an independent risk factor for vascular diseaseQ70131136
Homocysteine and vascular diseaseQ70992813
Topographical association between the cyclin-dependent kinases inhibitor P21, p53 accumulation, and cellular proliferation in human atherosclerotic tissueQ73832976
The effect of homocysteine on DNA synthesis in cultured human vascular smooth muscleQ74449548
Cooperative interactions between RB and p53 regulate cell proliferation, cell senescence, and apoptosis in human vascular smooth muscle cells from atherosclerotic plaquesQ74452665
Reduction of p53 gene expression in human primary hepatocellular carcinoma is associated with promoter region methylation without coding region mutationQ77530503
Homocysteine-mediated expression of SAHH, DNMTs, MBD2, and DNA hypomethylation potential pathogenic mechanism in VSMCsQ80771639
Aberrant DNA methylation of the PDGF gene in homocysteine‑mediated VSMC proliferation and its underlying mechanismQ87906859
The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumorsQ22010018
DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian developmentQ22010765
MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3BQ24564757
MicroRNAs: target recognition and regulatory functionsQ24609584
MicroRNA-26a is a novel regulator of vascular smooth muscle cell functionQ24624403
MicroRNA-145, a novel smooth muscle cell phenotypic marker and modulator, controls vascular neointimal lesion formationQ24650539
The functions of animal microRNAsQ27860621
MicroRNAs: genomics, biogenesis, mechanism, and functionQ27861070
A microRNA in a multiple-turnover RNAi enzyme complexQ28131835
Hyperhomocysteinemia enhances vascular inflammation and accelerates atherosclerosis in a murine modelQ28360470
Epigenetic modifications and human diseaseQ29619753
Mitogen-induced p53 downregulation precedes vascular smooth muscle cell migration from healthy tunica media and proliferationQ31825708
Heparan sulfate Ndst1 regulates vascular smooth muscle cell proliferation, vessel size and vascular remodelingQ33912429
p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblastsQ33986335
Enhanced levels of microRNA-125b in vascular smooth muscle cells of diabetic db/db mice lead to increased inflammatory gene expression by targeting the histone methyltransferase Suv39h1.Q34237731
MiR-125b orchestrates cell proliferation, differentiation and migration in neural stem/progenitor cells by targeting NestinQ34422892
miR‐146a and Krüppel‐like factor 4 form a feedback loop to participate in vascular smooth muscle cell proliferationQ34506077
Role of microRNAs in vascular diseases, inflammation, and angiogenesisQ34786294
MicroRNAs in Human Diseases: From Cancer to Cardiovascular DiseaseQ35157020
p53--a key player in tumoral and evolutionary adaptation: a lesson from the Israeli blind subterranean mole rat.Q36035396
A regulatory circuit of miR-148a/152 and DNMT1 in modulating cell transformation and tumor angiogenesis through IGF-IR and IRS1.Q36603339
Cell-specific effects of miR-221/222 in vessels: molecular mechanism and therapeutic applicationQ36877313
Involvement of connexin 43 in angiotensin II-induced migration and proliferation of saphenous vein smooth muscle cells via the MAPK-AP-1 signaling pathwayQ37395007
Tumor suppressive functions of p53Q37412688
MicroRNAs: a novel class of potential therapeutic targets for cardiovascular diseasesQ37646073
MicroRNA in intervertebral disc degeneration.Q38367405
miR-125b regulates calcification of vascular smooth muscle cellsQ38575745
Down-regulated microRNA-152 induces aberrant DNA methylation in hepatitis B virus-related hepatocellular carcinoma by targeting DNA methyltransferase 1.Q39688414
MicroRNA-125b is a novel negative regulator of p53.Q39871732
MicroRNA-modulated targeting of vascular smooth muscle cells.Q39954283
TP53 promoter methylation in human gliomasQ40396455
CpG methylation inactivates the transcriptional activity of the promoter of the human p53 tumor suppressor geneQ41104271
MicroRNA expression signature and antisense-mediated depletion reveal an essential role of MicroRNA in vascular neointimal lesion formationQ41166615
Folate treatment and unbalanced methylation and changes of allelic expression induced by hyperhomocysteinaemia in patients with uraemia.Q44454642
MiR-21 inhibits c-Ski signaling to promote the proliferation of rat vascular smooth muscle cellsQ44843537
Cell surface trafficking of Fas: a rapid mechanism of p53-mediated apoptosis.Q52532134
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectDNA methylationQ874745
P304page(s)95-104
P577publication date2016-07-14
P1433published inExperimental Cell ResearchQ1524289
P1476titlemiR-125b targets DNMT3b and mediates p53 DNA methylation involving in the vascular smooth muscle cells proliferation induced by homocysteine
P478volume347

Reverse relations

cites work (P2860)
Q64997592Aberrant MFN2 transcription facilitates homocysteine-induced VSMCs proliferation via the increased binding of c-Myc to DNMT1 in atherosclerosis.
Q41534142DDX3 localizes to the centrosome and prevents multipolar mitosis by epigenetically and translationally modulating p53 expression
Q50014666Dietary Modulation of the Epigenome
Q47100615Dnmt3b knock-down in enteric precursors reveals a possible mechanism by which this de novo methyltransferase is involved in the enteric nervous system development and the onset of Hirschsprung disease
Q93108587Dysregulation of Epigenetic Mechanisms of Gene Expression in the Pathologies of Hyperhomocysteinemia
Q91304776Homocysteine accelerates atherosclerosis by inhibiting scavenger receptor class B member1 via DNMT3b/SP1 pathway
Q47912637Hyperhomocysteinaemia and vascular injury: advances in mechanisms and drug targets.
Q49546439Liver X Receptor-Binding DNA Motif Associated With Atherosclerosis-Specific DNA Methylation Profiles of Alu Elements and Neighboring CpG Islands
Q91844720MicroRNA-125b in vascular diseases: An updated systematic review of pathogenetic implications and clinical applications
Q48326851MicroRNA-150 targets ELK1 and modulates the apoptosis induced by ox-LDL in endothelial cells.
Q94554680Radiation-Induced DNMT3B Promotes Radioresistance in Nasopharyngeal Carcinoma through Methylation of p53 and p21
Q92053513Role of DNA Methylation in the Development and Differentiation of Intestinal Epithelial Cells and Smooth Muscle Cells
Q39086830Simvastatin inhibits homocysteine-induced CRP generation via interfering with the ROS-p38/ERK1/2 signal pathway in rat vascular smooth muscle cells
Q38796278miR-34a Targets HDAC1-Regulated H3K9 Acetylation on Lipid Accumulation Induced by Homocysteine in Foam Cells

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