Neural stem cells as engraftable packaging lines can mediate gene delivery to microglia: evidence from studying retroviral env-related neurodegeneration

scientific article published on August 1999

Neural stem cells as engraftable packaging lines can mediate gene delivery to microglia: evidence from studying retroviral env-related neurodegeneration is …
instance of (P31):
scholarly articleQ13442814

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P932PMC publication ID112769
P698PubMed publication ID10400782

P2093author name stringA H Sharpe
E Y Snyder
W P Lynch
P2860cites workF4/80, a monoclonal antibody directed specifically against the mouse macrophageQ28281328
Multipotent neural cell lines can engraft and participate in development of mouse cerebellumQ28290006
Overcoming interference to retroviral superinfection results in amplified expression and transmission of cloned genesQ33634507
Three laboratory strains of spleen focus-forming virus: comparison of their genomes and translational productsQ33911777
Turnover of resident microglia in the normal adult mouse brainQ34435397
Cell therapyQ34467385
Lineage analysis in the vertebrate nervous system by retrovirus-mediated gene transferQ34585324
Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brainQ34693537
Antigen markers of macrophage differentiation in murine tissuesQ35483485
Murine retroviral neurovirulence correlates with an enhanced ability ofvirus to infect selectively, replicate in, and activate resident microglial cellsQ35831029
Induction of focal spongiform neurodegeneration in developmentally resistant mice by implantation of murine retrovirus-infected microglia.Q35833692
Characterization of a neurologic disease induced by a polytropic murine retrovirus: evidence for differential targeting of ecotropic and polytropic viruses in the brainQ35852738
Late virus replication events in microglia are required for neurovirulent retrovirus-induced spongiform neurodegeneration: evidence from neural progenitor-derived chimeric mouse brainsQ35874088
Neurological disease induced in transgenic mice expressing the env gene of the Cas-Br-E murine retrovirusQ36303669
Multipotent neural precursors can differentiate toward replacement of neurons undergoing targeted apoptotic degeneration in adult mouse neocortexQ36605438
Microglial infection by a neurovirulent murine retrovirus results in defective processing of envelope protein and intracellular budding of virus particles.Q36633809
Murine retrovirus-induced spongiform encephalopathy: disease expression is dependent on postnatal development of the central nervous systemQ36645249
Age-dependent resistance to murine retrovirus-induced spongiform neurodegeneration results from central nervous system-specific restriction of virus replicationQ36688988
Murine retrovirus-induced spongiform encephalomyelopathy: host and viral factors which determine the length of the incubation periodQ36697814
A neutralizable epitope common to the envelope glycoproteins of ecotropic, polytropic, xenotropic, and amphotropic murine leukemia virusesQ36796266
Neurodegenerative disease induced by the wild mouse ecotropic retrovirus is markedly accelerated by long terminal repeat and gag-pol sequences from nondefective Friend murine leukemia virusQ36803647
Ping-pong amplification of a retroviral vector achieves high-level gene expression: human growth hormone productionQ36811075
Monoclonal antibodies specific for wild mouse neurotropic retrovirus: detection of comparable levels of virus replication in mouse strains susceptible and resistant to paralytic disease.Q36855027
Generation of helper-free amphotropic retroviruses that transduce a dominant-acting, methotrexate-resistant dihydrofolate reductase geneQ36886039
Evidence that the packaging signal of Moloney murine leukemia virus extends into the gag regionQ36887904
A 1.6-kilobase-pair fragment in the genome of the ts1 mutant of Moloney murine leukemia virus TB that is associated with temperature sensitivity, nonprocessing of Pr80env, and paralytogenesisQ36901062
Redesign of retrovirus packaging cell lines to avoid recombination leading to helper virus productionQ36918698
Monoclonal xenogeneic antibodies to murine cell surface antigens: identification of novel leukocyte differentiation antigensQ39510598
Mac-1: a macrophage differentiation antigen identified by monoclonal antibodyQ39557974
Identification of the infected target cell type in spongiform myeloencephalopathy induced by the neurotropic Cas-Br-E murine leukemia virusQ40047960
Physical mapping of the paralysis-inducing determinant of a wild mouse ecotropic neurotropic retrovirusQ40134247
Microglial secretion products and their impact on the nervous system.Q40868888
Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's diseaseQ40870408
Microglia in degenerative neurological disease.Q40870414
The origin and nature of ramified and amoeboid microglia: a historical review and current conceptsQ40870421
The use of nonneuronal cells for gene deliveryQ40911146
Physiological relevance and functional potential of central nervous system-derived cell linesQ41056483
Stem cells in the central nervous systemQ41116811
Human immunodeficiency virus and the brainQ41132570
Is there a neural stem cell in the mammalian forebrain?Q41169054
Expression of human beta-hexosaminidase alpha-subunit gene (the gene defect of Tay-Sachs disease) in mouse brains upon engraftment of transduced progenitor cellsQ41212883
Neural stem cells are blasting off.Q41331504
Regulatory mechanisms in stem cell biologyQ41352398
Neural progenitor cell engraftment corrects lysosomal storage throughout the MPS VII mouse brainQ41358776
Bone marrow-derived elements in the central nervous system: an immunohistochemical and ultrastructural survey of rat chimerasQ41625499
Immortalized neural progenitor cells for CNS gene transfer and repair.Q41639955
Establishment and characterization of multipotent neural cell lines using retrovirus vector-mediated oncogene transferQ41741592
Murine retroviral-induced spongiform neuronal degeneration parallels resident microglial cell infection: ultrastructural findingsQ44948349
Lower motor neuron degeneration associated with type C RNA virus infection in mice: neuropathological featuresQ45075576
Development of pathological lesions in the central nervous system of transgenic mice expressing the env gene of ts1 Moloney murine leukemia virus in the absence of the viral gag and pol genes and viral replication.Q45760658
A spontaneous lower motor neuron disease apparently caused by indigenous type-C RNA virus in wild miceQ45819246
Cells expressing human glucocerebrosidase from a retroviral vector repopulate macrophages and central nervous system microglia after murine bone marrow transplantationQ45872830
Gene therapy -- promises, problems and prospectsQ45883584
Kinetic analysis of spongiform neurodegenerative disease induced by a highly virulent murine retrovirus.Q48125534
Differentiation of engrafted multipotent neural progenitors towards replacement of missing granule neurons in meander tail cerebellum may help determine the locus of mutant gene action.Q48617389
Murine retrovirus-induced spongiform encephalopathy: productive infection of microglia and cerebellar neurons in accelerated CNS diseaseQ48668986
Central nervous system cell transplantation: a novel therapy for storage diseases?Q49023545
Role of microglia and host prion protein in neurotoxicity of a prion protein fragmentQ49050987
Dissecting the determinants of neuropathogenesis of the murine oncornavirusesQ77097346
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectneurodegenerationQ1755122
neural stem cellQ2944097
microgliaQ1622829
P304page(s)6841-6851
P577publication date1999-08-01
P1433published inJournal of VirologyQ1251128
P1476titleNeural stem cells as engraftable packaging lines can mediate gene delivery to microglia: evidence from studying retroviral env-related neurodegeneration
P478volume73

Reverse relations

cites work (P2860)
Q37483966Applications of neural and mesenchymal stem cells in the treatment of gliomas
Q36694004Ecotropic Murine Leukemia Virus Infection of Glial Progenitors Interferes with Oligodendrocyte Differentiation: Implications for Neurovirulence
Q34666321Gene expression profiling of microglia infected by a highly neurovirulent murine leukemia virus: implications for neuropathogenesis
Q35217437Identification of a neuronal gene expression signature: role of cell cycle arrest in murine neuronal differentiation in vitro
Q34385134Implications and limitations of cellular reprogramming for psychiatric drug development
Q34192523MCP-1 and CCR2 contribute to non-lymphocyte-mediated brain disease induced by Fr98 polytropic retrovirus infection in mice: role for astrocytes in retroviral neuropathogenesis
Q39635226Misfolding of CasBrE SU is reversed by interactions with 4070A Env: implications for gammaretroviral neuropathogenesis
Q35827956Neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial gliomas
Q30405825Postinhibitory rebound neurons and networks are disrupted in retrovirus-induced spongiform neurodegeneration
Q40095203Rebound from Inhibition: Self-Correction against Neurodegeneration?
Q34741927Retrovirus-induced spongiform neurodegeneration is mediated by unique central nervous system viral targeting and expression of env alone
Q34153594Targeting β-secretase with RNAi in neural stem cells for Alzheimer's disease therapy
Q89553658The evolution of stem cells, disease modeling, and drug discovery for neurological disorders
Q37036721Unique N-linked glycosylation of CasBrE Env influences its stability, processing, and viral infectivity but not its neurotoxicity

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