Role of SR protein modular domains in alternative splicing specificity in vivo

scientific article published on December 2000

Role of SR protein modular domains in alternative splicing specificity in vivo is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1093/NAR/28.24.4822
P932PMC publication ID115228
P698PubMed publication ID11121472
P5875ResearchGate publication ID12208148

P2093author name stringJ F Cáceres
K Newton
G R Screaton
W van Der Houven Van Oordt
P2860cites workIdentification and characterization of three members of the human SR family of pre-mRNA splicing factorsQ24309346
Functional expression of cloned human splicing factor SF2: homology to rna-binding proteins, U1 70K, and drosophila splicing regulatorsQ24317722
A coactivator of pre-mRNA splicingQ24321729
Sorting out the complexity of SR protein functionsQ24539813
SAF-B protein couples transcription and pre-mRNA splicing to SAR/MAR elementsQ24548190
Functional domains of the human splicing factor ASF/SF2Q24564249
The human splicing factors ASF/SF2 and SC35 possess distinct, functionally significant RNA binding specificitiesQ24598907
Identification of functional exonic splicing enhancer motifs recognized by individual SR proteinsQ24600148
A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasmQ24609182
Analysis of the RNA-recognition motif and RS and RGG domains: conservation in metazoan pre-mRNA splicing factorsQ24629832
A Subset of SR Proteins Activates Splicing of the Cardiac Troponin T Alternative Exon by Direct Interactions with an Exonic EnhancerQ24651363
A mammalian germ cell-specific RNA-binding protein interacts with ubiquitously expressed proteins involved in splice site selectionQ24670000
Crystal structure of human UP1, the domain of hnRNP A1 that contains two RNA-recognition motifsQ27736500
Protein-protein interactions and 5'-splice-site recognition in mammalian mRNA precursorsQ28251112
Specific interactions between proteins implicated in splice site selection and regulated alternative splicingQ28257351
Specific commitment of different pre-mRNAs to splicing by single SR proteinsQ28262042
The HCF repeat is an unusual proteolytic cleavage signalQ28291563
Arginine/serine-rich domains of the su(wa) and tra RNA processing regulators target proteins to a subnuclear compartment implicated in splicingQ28303185
Regulated tissue-specific expression of antagonistic pre-mRNA splicing factors.Q28582631
The superfamily of arginine/serine-rich splicing factorsQ29618794
Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2Q29620278
Regulation of alternative splicing in vivo by overexpression of antagonistic splicing factorsQ29620283
The structure and function of proteins involved in mammalian pre-mRNA splicingQ29620286
Selection of alternative 5' splice sites: role of U1 snRNP and models for the antagonistic effects of SF2/ASF and hnRNP A1.Q33605355
Determinants of SR protein specificity.Q33680809
An amino acid sequence motif sufficient for subnuclear localization of an arginine/serine-rich splicing factorQ33705803
SR-related proteins and the processing of messenger RNA precursorsQ33765345
Exonic splicing enhancers: mechanism of action, diversity and role in human genetic diseasesQ33850031
The SR splicing factors ASF/SF2 and SC35 have antagonistic effects on intronic enhancer-dependent splicing of the beta-tropomyosin alternative exon 6AQ33886376
The splicing factor SRp20 modifies splicing of its own mRNA and ASF/SF2 antagonizes this regulationQ33887326
Analysis of the functional specificity of RS domains in vivoQ33889716
A systematic analysis of the factors that determine the strength of pre-mRNA splicing enhancers.Q33890073
Identification of a bidirectional splicing enhancer: differential involvement of SR proteins in 5' or 3' splice site activationQ33959923
Assembly of specific SR protein complexes on distinct regulatory elements of the Drosophila doublesex splicing enhancerQ34063109
Functional analysis of pre-mRNA splicing factor SF2/ASF structural domainsQ34070174
Exonic splicing enhancers contribute to the use of both 3' and 5' splice site usage of rat beta-tropomyosin pre-mRNAQ34361795
The splicing factors 9G8 and SRp20 transactivate splicing through different and specific enhancers.Q34361823
Functional characterization of SR and SR-related genes in Caenorhabditis elegansQ35008078
Antagonism between RSF1 and SR proteins for both splice-site recognition in vitro and Drosophila development.Q35191972
Genetic analysis of the SR protein ASF/SF2: interchangeability of RS domains and negative control of splicingQ35206040
The A1 and A1B proteins of heterogeneous nuclear ribonucleoparticles modulate 5' splice site selection in vivoQ35604494
Sequence-specific RNA binding by an SR protein requires RS domain phosphorylation: creation of an SRp40-specific splicing enhancerQ35989604
RNA splicing specificity determined by the coordinated action of RNA recognition motifs in SR proteinsQ36102488
Role of the modular domains of SR proteins in subnuclear localization and alternative splicing specificityQ36268125
A specific RNA hairpin loop structure binds the RNA recognition motifs of the Drosophila SR protein B52Q36568140
Expression of a human alpha-globin/fibronectin gene hybrid generates two mRNAs by alternative splicingQ36587176
Human fibronectin: molecular cloning evidence for two mRNA species differing by an internal segment coding for a structural domain.Q36592242
Functional association between promoter structure and transcript alternative splicing.Q36597450
The SR protein B52/SRp55 is essential for Drosophila developmentQ36669888
SR proteins promote the first specific recognition of Pre-mRNA and are present together with the U1 small nuclear ribonucleoprotein particle in a general splicing enhancer complexQ36670430
Inhibition by SR proteins of splicing of a regulated adenovirus pre-mRNA.Q36799268
Adenovirus E1A coding sequences that enable ras and pmt oncogenes to transform cultured primary cellsQ36911069
The Drosophila SR protein RBP1 contributes to the regulation of doublesex alternative splicing by recognizing RBP1 RNA target sequencesQ37621565
Function of conserved domains of hnRNP A1 and other hnRNP A/B proteins.Q37638748
The role of specific protein-RNA and protein-protein interactions in positive and negative control of pre-mRNA splicing by Transformer 2.Q38310868
Pathways for selection of 5' splice sites by U1 snRNPs and SF2/ASF.Q38316542
Coupling of transcription with alternative splicing: RNA pol II promoters modulate SF2/ASF and 9G8 effects on an exonic splicing enhancerQ38320513
Primary structure of the human splicing factor asf reveals similarities with drosophila regulatorsQ38334210
Substrate specificities of SR proteins in constitutive splicing are determined by their RNA recognition motifs and composite pre-mRNA exonic elementsQ39444777
A role for exon sequences in alternative splicing of the human fibronectin geneQ40390760
U1 snRNP-ASF/SF2 interaction and 5' splice site recognition: characterization of required elements.Q40395456
A novel bipartite splicing enhancer modulates the differential processing of the human fibronectin EDA exonQ40398994
The MKK(3/6)-p38-signaling cascade alters the subcellular distribution of hnRNP A1 and modulates alternative splicing regulationQ40886370
Blastocyst formation is blocked in mouse embryos lacking the splicing factor SRp20.Q40931954
The fibronectin gene as a model for splicing and transcription studies.Q40993754
The SR protein family: pleiotropic functions in pre-mRNA splicingQ41083714
Targeted disruption of an essential vertebrate gene: ASF/SF2 is required for cell viabilityQ41158296
Overexpression of the SR proteins ASF/SF2 and SC35 influences alternative splicing in vivo in diverse waysQ42000836
Distinct functions of the closely related tandem RNA-recognition motifs of hnRNP A1.Q43206297
Arginine/serine-rich domains of SR proteins can function as activators of pre-mRNA splicingQ47858254
Distinct functions of SR proteins in alternative pre-mRNA splicing.Q55066190
A splicing enhancer in the human fibronectin alternate ED1 exon interacts with SR proteins and stimulates U2 snRNP bindingQ72638665
General splicing factor SF2/ASF promotes alternative splicing by binding to an exonic splicing enhancerQ72693775
Direct interaction of the U1 snRNP-A protein with the upstream efficiency element of the SV40 late polyadenylation signalQ72718794
P433issue24
P407language of work or nameEnglishQ1860
P921main subjectalternative mRNA splicing, via spliceosomeQ21114084
P304page(s)4822-4831
P577publication date2000-12-01
P1433published inNucleic Acids ResearchQ135122
P1476titleRole of SR protein modular domains in alternative splicing specificity in vivo
P478volume28

Reverse relations

cites work (P2860)
Q24299148A novel SR-related protein is required for the second step of Pre-mRNA splicing
Q34144919A unique glutamic acid-lysine (EK) domain acts as a splicing inhibitor
Q47130222An oomycete plant pathogen reprograms host pre-mRNA splicing to subvert immunity
Q35813276Broad specificity of SR (serine/arginine) proteins in the regulation of alternative splicing of pre-messenger RNA.
Q34026146Comparative analysis of serine/arginine-rich proteins across 27 eukaryotes: insights into sub-family classification and extent of alternative splicing
Q35630437Differential Effects of Tra2ß Isoforms on HIV-1 RNA Processing and Expression
Q41589522Expression profile of a gamma-deletion variant of the human telomerase reverse transcriptase gene
Q24672773Human sat III and Drosophila hsr omega transcripts: a common paradigm for regulation of nuclear RNA processing in stressed cells
Q31035504Human splicing factor ASF/SF2 encodes for a repressor domain required for its inhibitory activity on pre-mRNA splicing
Q28570017Identification and characterization of the CDK12/cyclin L1 complex involved in alternative splicing regulation
Q74359881Identification of new poly(A) polymerase-inhibitory proteins capable of regulating pre-mRNA polyadenylation
Q48083368Insights into nuclear organization in plants as revealed by the dynamic distribution of Arabidopsis SR splicing factors
Q43029724Insights into the selective activation of alternatively used splice acceptors by the human immunodeficiency virus type-1 bidirectional splicing enhancer
Q24339165NSrp70 is a novel nuclear speckle-related protein that modulates alternative pre-mRNA splicing in vivo
Q34286089Nuclear export and retention signals in the RS domain of SR proteins
Q60352020Overexpression of SR proteins and splice variants modulates chondrogenesis
Q38076663Pick one, but be quick: 5' splice sites and the problems of too many choices
Q39946234RNA recognition motif 2 directs the recruitment of SF2/ASF to nuclear stress bodies
Q49818733Review of the molecular mechanisms in wound healing: new therapeutic targets?
Q24291847Serine-arginine (SR) protein-like factors that antagonize authentic SR proteins and regulate alternative splicing
Q24678283The U1 snRNP-associated factor Luc7p affects 5' splice site selection in yeast and human
Q33201134The second RNA-binding domain of the human splicing factor ASF/SF2 is the critical domain controlling adenovirus E1A alternative 5'-splice site selection
Q37083091Viral Interferon Regulatory Factor 1 of Kaposi's Sarcoma-Associated Herpesvirus Interacts with a Translocation Liposarcoma Protein-Associated Serine-Arginine Protein

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