Animal models of obsessive compulsive disorder: recent findings and future directions

scientific article published on 2 June 2011

Animal models of obsessive compulsive disorder: recent findings and future directions is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1517/17460441.2011.577772
P698PubMed publication ID22650979

P2093author name stringKurt Leroy Hoffman
P2860cites workThe mouse who couldn't stop washing: pathologic grooming in animals and humansQ24596552
Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice.Q24648260
The endocannabinoid system as an emerging target of pharmacotherapyQ24648473
Compulsive checking behavior of quinpirole-sensitized rats as an animal model of Obsessive-Compulsive Disorder(OCD): form and controlQ24797701
Sequential super-stereotypy of an instinctive fixed action pattern in hyper-dopaminergic mutant mice: a model of obsessive compulsive disorder and Tourette'sQ24797858
Evidence for a relationship between cage stereotypies and behavioural disinhibition in laboratory rodentsQ28208229
Passive transfer of streptococcus-induced antibodies reproduces behavioral disturbances in a mouse model of pediatric autoimmune neuropsychiatric disorders associated with streptococcal infectionQ28254420
Oxidative stress in psychiatric disorders: evidence base and therapeutic implicationsQ28265319
SLITRK1 mutations in trichotillomaniaQ28265621
Sequence variants in SLITRK1 are associated with Tourette's syndromeQ28276961
Quinpirole induces compulsive checking behavior in rats: a potential animal model of obsessive-compulsive disorder (OCD)Q28295896
Development and temporal organization of compulsive checking induced by repeated injections of the dopamine agonist quinpirole in an animal model of obsessive-compulsive disorderQ28300920
Motor/vocal tics and compulsive behaviors on stimulant drugs: is there a common vulnerability?Q28331516
Behavioural assessment of mice lacking D1A dopamine receptorsQ28506674
Hoxb8 is required for normal grooming behavior in miceQ28509145
Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive-like behaviors in miceQ28511908
Behavior-related alterations of striatal neurochemistry in a mouse model of stereotyped movement disorderQ33199027
Effect of apomorphine on the conflict-induced jumping stereotypy in bank volesQ33464271
Multiple rare SAPAP3 missense variants in trichotillomania and OCD.Q33578270
Indirect basal ganglia pathway mediation of repetitive behavior: attenuation by adenosine receptor agonistsQ33749330
Mitochondria are the source of hydrogen peroxide for dynamic brain-cell signalingQ33940987
A systematic review: antipsychotic augmentation with treatment refractory obsessive-compulsive disorderQ33994634
Childhood-onset obsessive-compulsive disorder: a tic-related subtype of OCD?Q34125235
PANDAS: current status and directions for researchQ34332001
The role of the striatum in compulsive behavior in intact and orbitofrontal-cortex-lesioned rats: possible involvement of the serotonergic systemQ34660619
The basal ganglia and chunking of action repertoiresQ34753448
Ovarian hormones modulate 'compulsive' lever-pressing in female ratsQ34876065
Novel drug interactions at D(2) dopamine receptors: modulation of [3H]quinpirole binding by monoamine oxidase inhibitorsQ34970953
Obsessive-compulsive disorder as a disturbance of security motivation.Q35645930
Understanding and treating incompleteness in obsessive-compulsive disorderQ35897187
A multidimensional model of obsessive-compulsive disorderQ36022775
Neurotransmitter receptor heteromers and their integrative role in 'local modules': the striatal spine module.Q36087867
Animal models of obsessive-compulsive disorder: rationale to understanding psychobiology and pharmacologyQ36464795
Systematic review: pharmacological and behavioral treatment for trichotillomaniaQ36922622
Altered dopamine D2-like receptor binding in rats with behavioral sensitization to quinpirole: effects of pre-treatment with Ro 41-1049Q36961449
Glutamatergic dysfunction--newer targets for anti-obsessional drugsQ37067439
Dimensional predictors of response to SRI pharmacotherapy in obsessive-compulsive disorderQ37682681
Refining the diagnostic boundaries of compulsive hoarding: a critical reviewQ37699810
Cortico-striatal oxidative status, dopamine turnover and relation with stereotypy in the deer mouseQ39772759
A novel, multiple symptom model of obsessive-compulsive-like behaviors in animalsQ39858637
Localized orbitofrontal and subcortical metabolic changes and predictors of response to paroxetine treatment in obsessive-compulsive disorderQ41713909
Impact of dopamine-glutamate interactions on striatal neuronal nitric oxide synthase activityQ42028032
A transgenic model of comorbid Tourette's syndrome and obsessive-compulsive disorder circuitryQ42681259
The role of NMDA receptors in the signal attenuation rat model of obsessive-compulsive disorderQ43125452
Excessive lever pressing following post-training signal attenuation in rats: a possible animal model of obsessive compulsive disorder?Q43620958
Spontaneous alternation behavior: An animal model for obsessive-compulsive disorder?Q43832913
Patients with obsessive-compulsive disorder are impaired in associative learning based on external feedbackQ44026684
Monoamine oxidase inhibitor-induced blockade of locomotor sensitization to quinpirole: role of striatal dopamine uptake inhibitionQ44146765
Selective alleviation of compulsive lever-pressing in rats by D1, but not D2, blockade: possible implications for the involvement of D1 receptors in obsessive-compulsive disorderQ44259226
Age differences in the sensitivity to clomipramine in an animal model of obsessive-compulsive disorderQ44317512
Cotreatment with the kappa opioid agonist U69593 enhances locomotor sensitization to the D2/D3 dopamine agonist quinpirole and alters dopamine D2 receptor and prodynorphin mRNA expression in ratsQ44335695
Kappa-opioid receptor stimulation quickens pathogenesis of compulsive checking in the quinpirole sensitization model of obsessive-compulsive disorder (OCD).Q44336423
Striatal opioid peptide content in an animal model of spontaneous stereotypic behaviorQ44347720
Selective blockade of spontaneous motor stereotypy via intrastriatal pharmacological manipulationQ44384952
Effects of intrastriatal administration of selective dopaminergic ligands on spontaneous stereotypy in miceQ44740585
Cross-cutting issues and future directions for the OCD spectrumQ45280768
Endocannabinoids mediate anxiolytic-like effect of acetaminophen via CB1 receptors.Q45938179
High-frequency stimulation of the nucleus accumbens core and shell reduces quinpirole-induced compulsive checking in rats.Q45986033
Cortico-striatal cyclic AMP-phosphodiesterase-4 signalling and stereotypy in the deer mouse: attenuation after chronic fluoxetine treatment.Q46000254
Sapap3 and pathological grooming in humans: Results from the OCD collaborative genetics study.Q46217993
High frequency stimulation and pharmacological inactivation of the subthalamic nucleus reduces 'compulsive' lever-pressing in ratsQ46296152
Compulsive-like behaviour according to the sex and the reproductive stage of female rats.Q46515277
The role of the subthalamic nucleus in 'compulsive' behavior in ratsQ46644712
Improvement in refractory obsessive compulsive disorder with dronabinolQ46669695
The role of 5-HT2A and 5-HT2C receptors in the signal attenuation rat model of obsessive-compulsive disorderQ46703278
High frequency stimulation and temporary inactivation of the subthalamic nucleus reduce quinpirole-induced compulsive checking behavior in ratsQ46852795
Stereotypic behaviour in the deer mouse: pharmacological validation and relevance for obsessive compulsive disorderQ46987238
An empirical test of the metacognitive model of obsessive-compulsive symptoms: fusion beliefs, beliefs about rituals, and stop signals.Q47649755
Belief domains of the Obsessive Beliefs Questionnaire-44 (OBQ-44) and their specific relationship with obsessive-compulsive symptoms.Q47789666
High but not low frequency stimulation of both the globus pallidus and the entopeduncular nucleus reduces 'compulsive' lever-pressing in ratsQ48115140
A rodent model of spontaneous stereotypy: initial characterization of developmental, environmental, and neurobiological factorsQ48205607
Moving beyond an exclusive focus on harm avoidance in obsessive-compulsive disorder: behavioral validation for the separability of harm avoidance and incompletenessQ48265145
Incompleteness and harm avoidance in OCD symptom dimensionsQ48340781
Caudate glucose metabolic rate changes with both drug and behavior therapy for obsessive-compulsive disorderQ48431922
Perseveration and not strategic deficits underlie delayed alternation impairment in obsessive-compulsive disorder (OCD).Q48436897
The exploratory behavior of rats in an open environment optimizes securityQ48447929
Toward an understanding of the neurobiology of "just right" perceptions: nest building in the female rabbit as a possible model for compulsive behavior and the perception of task completionQ48572400
To discard or not to discard: the neural basis of hoarding symptoms in obsessive-compulsive disorder.Q50876422
Cognitive confidence in obsessive-compulsive disorder: distrusting perception, attention and memory.Q50879115
A murine model for neuropsychiatric disorders associated with group A beta-hemolytic streptococcal infection.Q51029030
Evidence for specific cognitive deficits in visual information processing in patients with OCD compared to patients with unipolar depression.Q51053471
Obsessive-compulsive disorder: a disorder of pessimal (non-functional) motor behavior.Q51871374
Metacognition and episodic memory in obsessive-compulsive disorder.Q51872071
Implicit learning, thought-focused attention and obsessive-compulsive disorder: a replication and extension.Q51897561
Dissociation of decisions in ambiguous and risky situations in obsessive-compulsive disorder.Q51920559
Working memory dysfunction in obsessive-compulsive disorder: a neuropsychological and functional MRI study.Q51959961
Procedural learning and cognitive flexibility in a mouse model of restricted, repetitive behaviour.Q51964306
Response inhibition deficits in obsessive-compulsive disorder.Q52118830
Perseveration without hyperlocomotion in a spontaneous alternation task in rats sensitized to the dopamine agonist quinpirole.Q52211254
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectobsessive-compulsive disorderQ178190
P304page(s)725-737
P577publication date2011-06-02
P1433published inExpert Opinion on Drug DiscoveryQ5421204
P1476titleAnimal models of obsessive compulsive disorder: recent findings and future directions
P478volume6

Reverse relations

cites work (P2860)
Q38630519A review of animal models of obsessive-compulsive disorder: a focus on developmental, immune, endocrine and behavioral models
Q38353212Are 5-HT3 antagonists effective in obsessive-compulsive disorder? A systematic review of literature
Q35644240Association study of dopamine transporter gene (DAT1) variable tandem repeat sequence (VNTR) with obsessive-compulsive disorder in Chinese Han Population.
Q85964269Effects of the serotonergic agonist mCPP on male rats in the quinpirole sensitization model of obsessive-compulsive disorder (OCD)
Q39786914Excessive nest building is a unique behavioural phenotype in the deer mouse model of obsessive-compulsive disorder
Q49591645Lost in translation? A critical look at the role that animal models of obsessive compulsive disorder play in current drug discovery strategies
Q92748839Marble-burying behavior test as a murine model of compulsive-like behavior
Q53411379Mice deficient in AKAP13 (BRX) develop compulsive-like behavior and increased body weight.
Q33583797Nucleus accumbens core and pathogenesis of compulsive checking
Q38832138Obsessive-compulsive disorder: Insights from animal models
Q47566821Peromyscus maniculatus bairdii as a naturalistic mammalian model of obsessive-compulsive disorder: current status and future challenges
Q38900041Prader Willi Syndrome: Genetics, Metabolomics, Hormonal Function, and New Approaches to Therapy
Q28732413When too much is not enough: obsessive-compulsive disorder as a pathology of stopping, rather than starting

Search more.