Influence of glycosylation and oligomerization of vaccinia virus complement control protein on level and pattern of functional activity and immunogenicity

scientific article published on December 2010

Influence of glycosylation and oligomerization of vaccinia virus complement control protein on level and pattern of functional activity and immunogenicity is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S13238-010-0139-2
P932PMC publication ID4875074
P698PubMed publication ID21213103
P5875ResearchGate publication ID49735359

P2093author name stringGirish J Kotwal
P2860cites workSmallpox as a Biological WeaponQ22918878
CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choiceQ24286950
Internal homologies of the Ba fragment from human complement component Factor B, a class III MHC antigenQ24555650
Crystal structure of a complement control protein that regulates both pathways of complement activation and binds heparan sulfate proteoglycansQ27629908
Three-dimensional structure of a complement control protein module in solutionQ27649903
Vaccinia virus encodes a secretory polypeptide structurally related to complement control proteinsQ28297889
Vaccinia immune globulin: current policies, preparedness, and product safety and efficacyQ30230715
Conserved surface-exposed K/R-X-K/R motifs and net positive charge on poxvirus complement control proteins serve as putative heparin binding sites and contribute to inhibition of molecular interactions with human endothelial cells: a novel [...]Q33805943
Poxviral mimicry of complement and chemokine system components: what's the end game?Q33899303
Immunization against potential biological warfare agentsQ33958189
An attenuated LC16m8 smallpox vaccine: analysis of full-genome sequence and induction of immune protectionQ33987538
Variola virus immune evasion design: expression of a highly efficient inhibitor of human complementQ34066011
Electrostatic modeling predicts the activities of orthopoxvirus complement control proteinsQ34069057
Immunogenicity and safety of defective vaccinia virus lister: comparison with modified vaccinia virus AnkaraQ34343169
Virokines: novel immunomodulatory agentsQ34451942
Structure of vaccinia complement protein in complex with heparin and potential implications for complement regulationQ34829635
Restoration of complement-enhanced neutralization of vaccinia virus virions by novel monoclonal antibodies raised against the vaccinia virus complement control proteinQ35155228
Influences of glycosylation on antigenicity, immunogenicity, and protective efficacy of ebola virus GP DNA vaccinesQ35635459
Growing poxviruses and determining virus titerQ35758633
Oral immunization with a replication-deficient recombinant vaccinia virus protects mice against influenzaQ35868774
Developing new smallpox vaccinesQ37075201
Structure of transglutaminases.Q37594672
Target pattern recognition by complement proteins of the classical and alternative pathwaysQ37607220
Phenotypic and genetic diversity of the traditional Lister smallpox vaccineQ39908403
Genomic sequence of a clonal isolate of the vaccinia virus Lister strain employed for smallpox vaccination in France and its comparison to other orthopoxvirusesQ40122904
Structure and regulatory profile of the monkeypox inhibitor of complement: comparison to homologs in vaccinia and variola and evidence for dimer formationQ40308484
Highly attenuated smallpox vaccine protects rabbits and mice against pathogenic orthopoxvirus challengeQ40326131
Dose-dependent inhibition of complement in baboons by vaccinia virus complement control protein: implications in xenotransplantationQ40578979
Evidence for incomplete replication of a penguin poxvirus in cells of mammalian originQ41021966
Smallpox vaccines induce antibodies to the immunomodulatory, secreted vaccinia virus complement control proteinQ41188642
Purification of virokines using ultrafiltrationQ41446528
Regulation of complement activity by vaccinia virus complement-control proteinQ41897178
Humanized recombinant vaccinia virus complement control protein (hrVCP) with three amino acid changes, H98Y, E102K, and E120K creating an additional putative heparin binding site, is 100-fold more active than rVCP in blocking both classical and alteQ43882885
Inhibition of the complement cascade by the major secretory protein of vaccinia virusQ45006765
Vaccinia virus complement control protein ameliorates collagen-induced arthritic miceQ45421141
Vaccinia virus complement control protein increases early bacterial clearance during experimental peritonitisQ45667851
Vaccinia virus complement control protein inhibits hyperacute xenorejection in a guinea pig-to-rat heterotopic cervical cardiac xenograft model by blocking both xenoantibody binding and complement pathway activationQ45723011
Vaccinia virus complement control protein is monomeric, and retains structural and functional integrity after exposure to adverse conditionsQ45731552
Vaccinia virus complement control protein is capable of protecting xenoendothelial cells from antibody binding and killing by human complement and cytotoxic cellsQ45737584
The inflammation modulatory protein (IMP) of cowpox virus drastically diminishes the tissue damage by down-regulating cellular infiltration resulting from complement activationQ45753724
Interaction of vaccinia virus complement control protein with human complement proteins: factor I-mediated degradation of C3b to iC3b1 inactivates the alternative complement pathway.Q45755897
The cowpox virus-encoded homolog of the vaccinia virus complement control protein is an inflammation modulatory proteinQ45763563
Severe and prolonged inflammatory response to localized cowpox virus infection in footpads of C5-deficient mice: investigation of the role of host complement in poxvirus pathogenesisQ45785869
Dissecting Sites Important for Complement Regulatory Activity in Membrane Cofactor Protein (MCP; CD46)Q57936817
Membrane cofactor protein: importance of N- and O-glycosylation for complement regulatory functionQ64449897
Membrane cofactor protein (MCP; CD46). Isoforms differ in protection against the classical pathway of complementQ71151732
The purification fo four strains of poxvirusQ76491615
P433issue12
P921main subjectglycosylationQ898365
Vaccinia virusQ1986297
P1104number of pages9
P304page(s)1084-1092
P577publication date2010-12-01
P1433published inProtein & CellQ26854012
P1476titleInfluence of glycosylation and oligomerization of vaccinia virus complement control protein on level and pattern of functional activity and immunogenicity
P478volume1