SLCO1B1 genetic polymorphism influences mycophenolic acid tolerance in renal transplant recipients

scientific article published on December 2010

SLCO1B1 genetic polymorphism influences mycophenolic acid tolerance in renal transplant recipients is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.2217/PGS.10.132
P698PubMed publication ID21142914

P50authorLina QuteinehQ47156267
P2093author name stringJörg König
Martin F Fromm
Céline Verstuyft
Antoine Durrbach
Valérie Furlan
Bernard Charpentier
Sophie Ferlicot
Lina Quteineh
Laurent Becquemont
Alexia Letierce
Hugues Michelon
P2860cites workThe impact of uridine diphosphate-glucuronosyltransferase 1A9 (UGT1A9) gene promoter region single-nucleotide polymorphisms T-275A and C-2152T on early mycophenolic acid dose-interval exposure in de novo renal allograft recipientsQ46731220
Clinical pharmacokinetics of mycophenolate mofetilQ46787320
Individualized mycophenolate mofetil dosing based on drug exposure significantly improves patient outcomes after renal transplantationQ46972643
Influence of SLCO1B1, 1B3, 2B1 and ABCC2 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipientsQ46973712
Plasma concentrations of mycophenolic acid acyl glucuronide are not associated with diarrhea in renal transplant recipients.Q51913689
Risk of diarrhoea in a long-term cohort of renal transplant patients given mycophenolate mofetil: the significant role of the UGT1A8 2 variant alleleQ24595480
Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European- and African-AmericansQ28209488
IMPDH1 gene polymorphisms and association with acute rejection in renal transplant patientsQ28248331
High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1)Q28269517
Glucuronide and glucoside conjugation of mycophenolic acid by human liver, kidney and intestinal microsomesQ28354181
SLCO1B1 variants and statin-induced myopathy--a genomewide studyQ29619028
A new JAVA interface implementation of THESIAS: testing haplotype effects in association studies.Q33274432
Mycophenolate mofetil and its mechanisms of actionQ33957177
Rosuvastatin pharmacokinetics in heart transplant recipients administered an antirejection regimen including cyclosporineQ34338194
Clinical pharmacokinetics and pharmacodynamics of mycophenolate in solid organ transplant recipientsQ34573738
UGT genotype may contribute to adverse events following medication with mycophenolate mofetil in pediatric kidney transplant recipientsQ34947658
UGT1A9 -275T>A/-2152C>T polymorphisms correlate with low MPA exposure and acute rejection in MMF/tacrolimus-treated kidney transplant patientsQ34984788
Interpatient variability in IMPDH activity in MMF-treated renal transplant patients is correlated with IMPDH type II 3757T > C polymorphismQ34993014
Transporters and drug therapy: implications for drug disposition and diseaseQ36253732
Therapeutic drug monitoring of mycophenolate mofetil in transplantationQ36455259
Role of OATP transporters in the disposition of drugsQ37074085
Therapeutic monitoring of mycophenolate in transplantation: is it justified?Q37411261
The role of organic anion-transporting polypeptides and their common genetic variants in mycophenolic acid pharmacokinetics.Q39778798
The influence of macrolide antibiotics on the uptake of organic anions and drugs mediated by OATP1B1 and OATP1B3.Q40171773
Influence of nonsynonymous polymorphisms of UGT1A8 and UGT2B7 metabolizing enzymes on the formation of phenolic and acyl glucuronides of mycophenolic acidQ40264387
Characterization of a phase 1 metabolite of mycophenolic acid produced by CYP3A4/5.Q40486663
Mycophenolate mofetil in renal allograft recipients: a pooled efficacy analysis of three randomized, double-blind, clinical studies in prevention of rejection. The International Mycophenolate Mofetil Renal Transplant Study GroupsQ42551535
Identification of glucoside and carboxyl-linked glucuronide conjugates of mycophenolic acid in plasma of transplant recipients treated with mycophenolate mofetilQ43189802
Influence of UDP-glucuronosyltransferase polymorphisms on mycophenolate mofetil-induced side effects in kidney transplant patients.Q43718019
Mycophenolate mofetil dose reduction and the risk of acute rejection after renal transplantation.Q44360338
Mechanism-based enterohepatic circulation model of mycophenolic acid and its glucuronide metabolite: assessment of impact of cyclosporine dose in Asian renal transplant patients.Q46040442
The pharmacokinetics of mycophenolate mofetil in renal transplant recipients receiving standard-dose or low-dose cyclosporine, low-dose tacrolimus or low-dose sirolimus: the Symphony pharmacokinetic substudyQ46055999
Influence of CYP3A5 genetic polymorphism on tacrolimus daily dose requirements and acute rejection in renal graft recipientsQ46207616
Opportunities for therapeutic monitoring of mycophenolate mofetil dose in renal transplantation suggested by the pharmacokinetic/pharmacodynamic relationship for mycophenolic acid and suppression of rejectionQ46246052
Comparing mycophenolate mofetil regimens for de novo renal transplant recipients: the fixed-dose concentration-controlled trialQ46301570
Cyclosporine interacts with mycophenolic acid by inhibiting the multidrug resistance-associated protein 2.Q46427135
Influence of drug transporters and UGT polymorphisms on pharmacokinetics of phenolic glucuronide metabolite of mycophenolic acid in Japanese renal transplant recipientsQ46434574
The impact of P-glycoprotein and Mrp2 on mycophenolic acid levels in miceQ46513372
Disposition of ezetimibe is influenced by polymorphisms of the hepatic uptake carrier OATP1B1.Q46542409
A double absorption-phase model adequately describes mycophenolic acid plasma profiles in de novo renal transplant recipients given oral mycophenolate mofetilQ46608340
P433issue12
P304page(s)1703-1713
P577publication date2010-12-01
P1433published inPharmacogenomicsQ15724625
P1476titleSLCO1B1 genetic polymorphism influences mycophenolic acid tolerance in renal transplant recipients
P478volume11

Reverse relations

cites work (P2860)
Q45345117Challenges and Opportunities with Predicting in Vivo Phase II Metabolism via Glucuronidation from in Vitro Data
Q38223136Do Asian renal transplant patients need another mycophenolate mofetil dose compared with Caucasian or African American patients?
Q38104742Genes and beans: pharmacogenomics of renal transplant
Q36183911Impact of Single Nucleotide Polymorphisms (SNPs) on Immunosuppressive Therapy in Lung Transplantation.
Q55715295Influence of uridine diphosphate-glucuronosyltransferases (1A9) polymorphisms on mycophenolic acid pharmacokinetics in patients with renal transplant.
Q38162034PharmGKB summary: mycophenolic acid pathway
Q38258677Pharmacogenetics and immunosuppressive drugs.
Q99630950Pharmacogenetics of immunosuppressant drugs: A new aspect for individualized therapy
Q38208983Pharmacology and toxicology of mycophenolate in organ transplant recipients: an update
Q26829263Plasma membrane transporters in modern liver pharmacology
Q51048064Population pharmacogenetic pharmacokinetic modeling for flip-flop phenomenon of enteric-coated mycophenolate sodium in kidney transplant recipients.
Q46498636Renal glucuronidation and multidrug resistance protein 2-/ multidrug resistance protein 4-mediated efflux of mycophenolic acid: interaction with cyclosporine and tacrolimus.
Q37933139The genetics of kidney transplantation
Q27009825The influence of UGT polymorphisms as biomarkers in solid organ transplantation
Q37862576Transporter-mediated drug uptake and efflux: important determinants of adverse drug reactions
Q45993586Uridine diphosphate glucuronosyltransferase 2B7 variant p.His268Tyr as a predictor of kidney allograft early acute rejection.

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