Influence of an additional amino group on the potency of aminoadamantanes against influenza virus A. II - Synthesis of spiropiperazines and in vitro activity against influenza A H3N2 virus.

scientific article published on 21 September 2010

Influence of an additional amino group on the potency of aminoadamantanes against influenza virus A. II - Synthesis of spiropiperazines and in vitro activity against influenza A H3N2 virus. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.BIOORG.2010.09.001
P932PMC publication ID2997423
P698PubMed publication ID20926112
P5875ResearchGate publication ID47356952

P50authorChristopher F BaslerQ54188848
George FytasQ56856798
Grigoris ZoidisQ81552855
P2093author name stringAntonios Kolocouris
Charalampos Valmas
Christos Fytas
P2860cites workIon channel activity of influenza A virus M2 protein: characterization of the amantadine blockQ24655972
Structural basis for the function and inhibition of an influenza virus proton channelQ27649742
Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayersQ27659500
Characterization of the 1918 influenza virus polymerase genesQ28275749
Transmission and pathogenesis of swine-origin 2009 A(H1N1) influenza viruses in ferrets and miceQ29619193
The molecular basis of the specific anti-influenza action of amantadineQ33931939
Influenza virus M2 protein has ion channel activityQ34248853
Unraveling the mystery of swine influenza virusQ34986617
Reevaluating equilibrium and kinetic binding parameters for lipophilic drugs based on a structural model for drug interaction with biological membranesQ37660195
Influence of an additional 2-amino substituent of the 1-aminoethyl pharmacophore group on the potency of rimantadine against influenza virus A.Q40206875
Spiro[pyrrolidine-2,2'-adamantanes]: synthesis, anti-influenza virus activity and conformational propertiesQ40590467
Heterocyclic rimantadine analogues with antiviral activityQ40612283
Synthesis of substituted 1-norbornylamines with antiviral activityQ40678852
Synthesis and antiviral activity evaluation of some new aminoadamantane derivatives. 2.Q41174349
Synthesis and antiviral activity evaluation of some aminoadamantane derivativesQ41443005
Maturation of influenza A virus hemagglutinin--estimates of the pH encountered during transport and its regulation by the M2 proteinQ41603952
Synthesis and antiviral activities of adamantane spiro compounds. 1. Adamantane and analogous spiro-3'-pyrrolidinesQ42231855
Antiviral agents. 2. Structure-activity relations of compounds related to 1-adamantanamineQ42237423
Selective proton permeability and pH regulation of the influenza virus M2 channel expressed in mouse erythroleukaemia cells.Q43595146
Novel 3-(2-adamantyl)pyrrolidines with potent activity against influenza A virus-identification of aminoadamantane derivatives bearing two pharmacophoric amine groupsQ43713806
Are the 2-isomers of the drug rimantadine active anti-influenza A agents?Q44604102
Comparisons of the influenza virus A M2 channel binding affinities, anti-influenza virus potencies and NMDA antagonistic activities of 2-alkyl-2-aminoadamantanes and analoguesQ45389158
Evidence that the amantadine-induced, M2-mediated conversion of influenza A virus hemagglutinin to the low pH conformation occurs in an acidic trans Golgi compartmentQ45867009
Neutron diffraction reveals the site of amantadine blockade in the influenza A M2 ion channel.Q54201601
Synthesis and antiviral activities of adamantane spiro compounds. 2Q67272897
Anti-influenza A activity of some N-substituted bicyclo[3.2.1]octane-3-spiro-3'-pyrrolidine hydrochlorides: synthesis and structureQ70651697
Preparation of substituted piperazinones via tandem reductive amination-(N,N'-acyl transfer)-cyclizationQ77845588
P433issue6
P304page(s)247-251
P577publication date2010-09-21
P1433published inBioorganic ChemistryQ2904198
P1476titleInfluence of an additional amino group on the potency of aminoadamantanes against influenza virus A. II - Synthesis of spiropiperazines and in vitro activity against influenza A H3N2 virus
P478volume38

Reverse relations

cites work (P2860)
Q28084005Compounds with anti-influenza activity: present and future of strategies for the optimal treatment and management of influenza. Part II: Future compounds against influenza virus
Q94453854Elucidation of the mechanism of anti-herpes action of two novel semisynthetic cardenolide derivatives
Q30234943Progress of small molecular inhibitors in the development of anti-influenza virus agents

Search more.