The Tat protein of human immunodeficiency virus type 1 (HIV-1) can promote placement of tRNA primer onto viral RNA and suppress later DNA polymerization in HIV-1 reverse transcription.

scientific article published on April 2002

The Tat protein of human immunodeficiency virus type 1 (HIV-1) can promote placement of tRNA primer onto viral RNA and suppress later DNA polymerization in HIV-1 reverse transcription. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.76.8.3637-3645.2002
P932PMC publication ID136076
P698PubMed publication ID11907203

P50authorMark WainbergQ3294273
Masanori KameokaQ45370028
Max MorganQ77801227
P2093author name stringRodney S Russell
Lawrence Kleiman
Chen Liang
Xiaofeng Guo
Liwei Rong
Andrew Mouland
Marc Binette
P2860cites workEffect of human immunodeficiency virus type 1 (HIV-1) nucleocapsid protein on HIV-1 reverse transcriptase activity in vitroQ38362867
Genetic analysis of a unique human immunodeficiency virus type 1 (HIV-1) with a primer binding site complementary to tRNAMet supports a role for U5-PBS stem-loop RNA structures in initiation of HIV-1 reverse transcriptionQ39551629
The role of nucleocapsid and U5 stem/A-rich loop sequences in tRNA(3Lys) genomic placement and initiation of reverse transcription in human immunodeficiency virus type 1.Q39578385
Analysis of the nucleic acid annealing activities of nucleocapsid protein from HIV-1.Q40394716
Facilitation of hammerhead ribozyme catalysis by the nucleocapsid protein of HIV-1 and the heterogeneous nuclear ribonucleoprotein A1Q40792302
An RNA chaperone activity of non-specific RNA binding proteins in hammerhead ribozyme catalysisQ40792308
The prion protein has RNA binding and chaperoning properties characteristic of nucleocapsid protein NCP7 of HIV-1.Q40817022
HIV-1 tat protein stimulates transcription by binding to a U-rich bulge in the stem of the TAR RNA structureQ41234955
TAR-independent activation of the HIV-1 LTR: evidence that tat requires specific regions of the promoterQ41724573
High affinity binding of TAR RNA by the human immunodeficiency virus type-1 tat protein requires base-pairs in the RNA stem and amino acid residues flanking the basic regionQ43480910
Identification and characterization of the RNA chaperone activity of hepatitis delta antigen peptidesQ43964028
Effects of mutations in Pr160gag-pol upon tRNA(Lys3) and Pr160gag-plo incorporation into HIV-1.Q45204272
The annealing of tRNA3Lys to human immunodeficiency virus type 1 primer binding site is critically dependent on the NCp7 zinc fingers structureQ45757764
Tat protein from human immunodeficiency virus forms a metal-linked dimerQ45841752
The prion protein has DNA strand transfer properties similar to retroviral nucleocapsid protein.Q54014038
Rapid purification of homodimer and heterodimer HIV-1 reverse transcriptase by metal chelate affinity chromatography.Q54718103
The GAG-like protein of the yeast Ty1 retrotransposon contains a nucleic acid chaperone domain analogous to retroviral nucleocapsid proteinsQ73680394
Sequences within Pr160gag-pol affecting the selective packaging of primer tRNA(Lys3) into HIV-1Q73910219
Nucleic-acid-chaperone activity of retroviral nucleocapsid proteins: significance for viral replicationQ77362262
HIV-I Tat: a polypeptide for all seasonsQ77723670
HIV-1 Tat protein is poly(ADP-ribosyl)ated in vitroQ77998845
The double-stranded RNA-binding protein Staufen is incorporated in human immunodeficiency virus type 1: evidence for a role in genomic RNA encapsidationQ24525207
Incorporation of lysyl-tRNA synthetase into human immunodeficiency virus type 1Q24529517
TAR-independent transactivation by Tat in cells derived from the CNS: a novel mechanism of HIV-1 gene regulationQ24555668
Structural studies of HIV-1 Tat proteinQ27730186
Complete nucleotide sequence of the AIDS virus, HTLV-IIIQ28259080
First glimpses at structure-function relationships of the nucleocapsid protein of retrovirusesQ28285187
Identification of tRNAs incorporated into wild-type and mutant human immunodeficiency virus type 1Q28646853
Control of RNA initiation and elongation at the HIV-1 promoterQ29620157
The role of Pr55(gag) in the annealing of tRNA3Lys to human immunodeficiency virus type 1 genomic RNAQ30453508
The human immunodeficiency virus type 1 Gag polyprotein has nucleic acid chaperone activity: possible role in dimerization of genomic RNA and placement of tRNA on the primer binding siteQ33647840
Functional domains of Tat required for efficient human immunodeficiency virus type 1 reverse transcription.Q33654155
Multifaceted activities of the HIV-1 transactivator of transcription, Tat.Q33743566
Cell cycle-regulated transcription by the human immunodeficiency virus type 1 Tat transactivatorQ33795939
Role for human immunodeficiency virus type 1 Tat protein in suppression of viral reverse transcriptase activity during late stages of viral replicationQ33865436
Multiple functional domains of Tat, the trans-activator of HIV-1, defined by mutational analysisQ35226113
Specific initiation and switch to elongation of human immunodeficiency virus type 1 reverse transcription require the post-transcriptional modifications of primer tRNA3LysQ35853488
Human immunodeficiency virus type 1 nucleocapsid protein reduces reverse transcriptase pausing at a secondary structure near the murine leukemia virus polypurine tractQ35870861
Nucleotide substitutions within U5 are critical for efficient reverse transcription of human immunodeficiency virus type 1 with a primer binding site complementary to tRNA(His)Q35890905
Binding and kinetic properties of HIV-1 reverse transcriptase markedly differ during initiation and elongation of reverse transcription.Q35917913
TAR-independent transactivation of the murine cytomegalovirus major immediate-early promoter by the Tat proteinQ36639281
Release, uptake, and effects of extracellular human immunodeficiency virus type 1 Tat protein on cell growth and viral transactivationQ36639380
The full-length Tat protein is required for TAR-independent, posttranscriptional trans activation of human immunodeficiency virus type 1 env gene expression.Q36649447
Viral RNA annealing activities of human immunodeficiency virus type 1 nucleocapsid protein require only peptide domains outside the zinc fingersQ37111477
Human immunodeficiency viruses regulated by alternative trans-activators: genetic evidence for a novel non-transcriptional function of Tat in virion infectivity.Q37633631
Comparison of deoxyoligonucleotide and tRNA(Lys-3) as primers in an endogenous human immunodeficiency virus-1 in vitro reverse transcription/template-switching reactionQ38308091
Protein Enhancement of Hammerhead Ribozyme CatalysisQ38315678
Mechanistic studies of early pausing events during initiation of HIV-1 reverse transcriptionQ38334633
Distinct transcriptional pathways of TAR-dependent and TAR-independent human immunodeficiency virus type-1 transactivation by Tat.Q38343402
Tat is required for efficient HIV-1 reverse transcriptionQ38347693
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectDNA polymerizationQ47399938
P304page(s)3637-3645
P577publication date2002-04-01
P1433published inJournal of VirologyQ1251128
P1476titleThe Tat protein of human immunodeficiency virus type 1 (HIV-1) can promote placement of tRNA primer onto viral RNA and suppress later DNA polymerization in HIV-1 reverse transcription
P478volume76

Reverse relations

cites work (P2860)
Q35488480A mutant tat protein inhibits HIV-1 reverse transcription by targeting the reverse transcription complex.
Q37864135Challenges in understanding the immunopathogenesis of Cryptosporidium infections in humans
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Q38022377Comparative nucleic acid chaperone properties of the nucleocapsid protein NCp7 and Tat protein of HIV-1.
Q36099319Construction of a doxycycline-dependent simian immunodeficiency virus reveals a nontranscriptional function of tat in viral replication.
Q37518644Dynamic interactions of the HIV-1 Tat with nucleic acids are critical for Tat activity in reverse transcription.
Q26746070HIV Genome-Wide Protein Associations: a Review of 30 Years of Research
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Q34768563HIV-1 regulatory proteins: targets for novel drug development
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Q38021305The role of Vif oligomerization and RNA chaperone activity in HIV-1 replication
Q35990905Vif is a RNA chaperone that could temporally regulate RNA dimerization and the early steps of HIV-1 reverse transcription