The recombinant chimeric antibody chHAb18 against hepatocellular carcinoma can be produced in milk of transgenic mice

scientific article published on 12 June 2010

The recombinant chimeric antibody chHAb18 against hepatocellular carcinoma can be produced in milk of transgenic mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S11248-010-9408-3
P698PubMed publication ID20549347

P2093author name stringNing Li
Min Zheng
Meili Wang
Yunping Dai
Zhinan Chen
Xiangmin Yang
Jingjing Wei
P2860cites workRoles of the multifunctional glycoprotein, emmprin (basigin; CD147), in tumour progressionQ28235067
Transgenic milk as a method for the production of recombinant antibodiesQ33825189
Virus-neutralizing monoclonal antibody expressed in milk of transgenic mice provides full protection against virus-induced encephalitis.Q33865777
Position-effect protection and enhancer blocking by the chicken beta-globin insulator are separable activitiesQ34067751
Trastuzumab: hopes and realitiesQ34569899
Recombinant protein expression for therapeutic applicationsQ34598013
Production of pharmaceutical proteins by transgenic animalsQ34744705
Emmprin (CD147), a cell surface regulator of matrix metalloproteinase production and functionQ35107639
Current and future issues in the manufacturing and development of monoclonal antibodiesQ36530980
Process economics of industrial monoclonal antibody manufactureQ36561343
A generic intron increases gene expression in transgenic miceQ36695893
Molecular insight in cancer treatment and preventionQ36832697
Salvage surgery following downstaging of unresectable hepatocellular carcinoma--a strategy to increase resectabilityQ36949907
Hepatocellular carcinoma: current management and recent advances.Q37181474
Variegated transgene expression in mouse mammary gland is determined by the transgene integration locus.Q37536110
Functional recombinant human anti-HAV antibody expressed in milk of transgenic miceQ40011772
HAb18G/CD147 functions in invasion and metastasis of hepatocellular carcinomaQ40117761
HAb18G/CD147 enhances the secretion of matrix metalloproteinases (MMP) via cGMP/NO-sensitive capacitative calcium entry (CCE) and accordingly attenuates adhesion ability of fibroblasts.Q40455767
Enhancing the efficiency of transgene expressionQ40709323
The involvement of HAb18G/CD147 in regulation of store-operated calcium entry and metastasis of human hepatoma cellsQ40776133
Position-independent expression of the ovine beta-lactoglobulin gene in transgenic miceQ41855725
Effective treatment of unresectable or metastatic hepatoblastoma with cisplatin and continuous infusion doxorubicin chemotherapy: a report from the Childrens Cancer Study GroupQ42167893
Cloning of the goat beta-casein-encoding gene and expression in transgenic miceQ44048484
Rescuing transgene expression by co-integrationQ45216176
Biodistribution and localization of iodine-131-labeled metuximab in patients with hepatocellular carcinomaQ46947298
HAb18G (CD147), a cancer-associated biomarker and its role in cancer detectionQ47811362
Targeting radioimmunotherapy of hepatocellular carcinoma with iodine (131I) metuximab injection: clinical phase I/II trials.Q51204083
Intronic sequences modulate the sensitivity of β-lactoglobulin transgenes to position effectsQ64463868
Systemic therapy for hepatocellular carcinomaQ81025242
Monoclonal antibody therapy of cancerQ81189032
P433issue2
P921main subjecthepatocellular carcinomaQ1148337
P304page(s)321-330
P577publication date2010-06-12
P1433published inTransgenic ResearchQ7834239
P1476titleThe recombinant chimeric antibody chHAb18 against hepatocellular carcinoma can be produced in milk of transgenic mice
P478volume20

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cites work (P2860)
Q56557417A novel recombinant human plasminogen activator: Efficient expression and hereditary stability in transgenic goats and in vitro thrombolytic bioactivity in the milk of transgenic goats
Q42161184Efficient stabilization of recombinant human coagulation factor VIII in the milk of transgenic mice using hFVIII and vWF co-expression vector transduction
Q54335262Expression of biologically active human interferon alpha 2b in the milk of transgenic mice.
Q38126016Expression of recombinant antibodies
Q42801733Expression of threonine-biosynthetic genes in mammalian cells and transgenic mice
Q51119286Production of transgenic dairy goat expressing human α-lactalbumin by somatic cell nuclear transfer.