The cdk5 kinase regulates the STAT3 transcription factor to prevent DNA damage upon topoisomerase I inhibition.

scientific article published in June 2010

The cdk5 kinase regulates the STAT3 transcription factor to prevent DNA damage upon topoisomerase I inhibition. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M109.092304
P932PMC publication ID2930675
P698PubMed publication ID20516069

P50authorOlivier CoqueretQ51594132
Sophie de Carné TrécessonQ83366076
Arnaud M VigneronQ114435562
Erick GamelinQ114435588
P2093author name stringBenjamin Barré
Hélène Sellier
Anne-Charlotte Bernard
Sandy Courapied
P2860cites workSynergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300Q22009398
Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumorsQ24312920
Cyclin-dependent kinase inhibitors uncouple cell cycle progression from mitochondrial apoptotic functions in DNA-damaged cancer cells.Q40400655
Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathwayQ40410769
STAT-1 facilitates the ATM activated checkpoint pathway following DNA damageQ40443547
Transcriptional regulation by a DNA-associated form of cyclin D1.Q40468965
Implication of BRG1 and cdk9 in the STAT3-mediated activation of the p21waf1 geneQ40529870
Cellular senescence requires CDK5 repression of Rac1 activityQ40578044
BCR/ABL regulates mammalian RecA homologs, resulting in drug resistanceQ40771883
Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cellsQ40972355
STAT3 is required for the gp130-mediated full activation of the c-myc geneQ42753357
Novel roles of unphosphorylated STAT3 in oncogenesis and transcriptional regulationQ45261333
Signal transducer and activator of transcription 3 is a key regulator of keratinocyte survival and proliferation following UV irradiation.Q46581121
The EGFR-STAT3 oncogenic pathway up-regulates the Eme1 endonuclease to reduce DNA damage after topoisomerase I inhibitionQ46775298
Activation of stat3 in primary tumors from high-risk breast cancer patients is associated with elevated levels of activated SRC and survivin expressionQ46882515
The STAT3 transcription factor is a target for the Myc and riboblastoma proteins on the Cdc25A promoter.Q51594081
The STAT3 oncogene as a predictive marker of drug resistance.Q53339800
Increased ezrin expression and activation by CDK5 coincident with acquisition of the senescent phenotype.Q53379260
Interleukin-6 dependent induction of the cyclin dependent kinase inhibitor p21WAF1/CIP1 is lost during progression of human malignant melanoma.Q54104985
What does Stat3 do?Q57203833
c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instabilityQ74243929
Activation of signal transducer and activator of transcription 3 through a phosphomimetic serine 727 promotes prostate tumorigenesis independent of tyrosine 705 phosphorylationQ24632832
Stat protein transactivation domains recruit p300/CBP through widely divergent sequencesQ28143105
Repair of and checkpoint response to topoisomerase I-mediated DNA damageQ28187875
Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1aQ28214385
Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylationQ28288257
Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activityQ28512261
Cdk5-Mediated Inhibition of the Protective Effects of Transcription Factor MEF2 in Neurotoxicity-Induced ApoptosisQ28571515
Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and regulates neuronal deathQ28583434
The STATs of cancer--new molecular targets come of ageQ29614601
Stat3 as an oncogeneQ29614606
Cross-linking of signal transducer and activator of transcription 3--a molecular marker for the photodynamic reaction in cells and tumorsQ33286513
Stat3 activation is required for cellular transformation by v-srcQ33786469
Disruption of murine Mus81 increases genomic instability and DNA damage sensitivity but does not promote tumorigenesisQ33925085
Role of Stat3 in regulating p53 expression and functionQ33925115
Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesisQ33951212
Constitutively activated Stat3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Stat1Q34088483
A decade of CDK5.Q34093501
Fusion tyrosine kinases induce drug resistance by stimulation of homology-dependent recombination repair, prolongation of G(2)/M phase, and protection from apoptosisQ34281241
Apoptosis: a link between cancer genetics and chemotherapyQ34520432
Stat proteins and oncogenesisQ34627064
What does Stat3 do?Q34627068
Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaBQ35812229
Exploring the roles of Mus81-Eme1/Mms4 at perturbed replication forksQ36780382
Targeting signal transducer and activator of transcription signaling pathway in leukemias.Q37347522
A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitorQ38279200
How Stat1 mediates constitutive gene expression: a complex of unphosphorylated Stat1 and IRF1 supports transcription of the LMP2 geneQ38309989
STAT1: a modulator of chemotherapy-induced apoptosisQ38334162
Opposite regulation of myc and p21waf1 transcription by STAT3 proteinsQ38360847
DNA replication stalling attenuates tyrosine kinase signaling to suppress S phase progression.Q39952268
Cooperative roles of c-Abl and Cdk5 in regulation of p53 in response to oxidative stressQ39980637
Cdk5 regulates STAT3 activation and cell proliferation in medullary thyroid carcinoma cellsQ40200998
Signal transducers and activators of transcription 3 pathway activation in drug-resistant ovarian cancerQ40236285
The cell cycle inhibitor p21waf1 binds to the myc and cdc25A promoters upon DNA damage and induces transcriptional repressionQ40241168
Cyclin D1 is transcriptionally regulated by and required for transformation by activated signal transducer and activator of transcription 3.Q40309855
Cisplatin mimics ARF tumor suppressor regulation of RelA (p65) nuclear factor-kappaB transactivationQ40327525
Persistent activation of stat3 signaling induces survivin gene expression and confers resistance to apoptosis in human breast cancer cellsQ40333333
Cyclin-dependent kinase-5 prevents neuronal apoptosis through ERK-mediated upregulation of Bcl-2.Q40354092
Src inhibits adriamycin-induced senescence and G2 checkpoint arrest by blocking the induction of p21waf1.Q40365756
P433issue35
P407language of work or nameEnglishQ1860
P921main subjectDNA damageQ5205747
P304page(s)26765-26778
P577publication date2010-06-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe cdk5 kinase regulates the STAT3 transcription factor to prevent DNA damage upon topoisomerase I inhibition
P478volume285