Functional and genetic studies of the substrate specificity of coronavirus infectious bronchitis virus 3C-like proteinase

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Functional and genetic studies of the substrate specificity of coronavirus infectious bronchitis virus 3C-like proteinase is …
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scholarly articleQ13442814

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P356DOI10.1128/JVI.02490-09
P932PMC publication ID2898227
P698PubMed publication ID20444893
P5875ResearchGate publication ID44575483

P2093author name stringShouguo Fang
Ding Xiang Liu
Felicia P L Tay
Hongyuan Shen
Jibin Wang
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Characterisation and mutational analysis of an ORF 1a-encoding proteinase domain responsible for proteolytic processing of the infectious bronchitis virus 1a/1b polyproteinQ42686105
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3C-like proteinase from SARS coronavirus catalyzes substrate hydrolysis by a general base mechanismQ44839752
The substrate specificity of SARS coronavirus 3C-like proteinaseQ45308590
Proteolytic processing of polyproteins 1a and 1ab between non-structural proteins 10 and 11/12 of Coronavirus infectious bronchitis virus is dispensable for viral replication in cultured cells.Q45392340
An arginine-to-proline mutation in a domain with undefined functions within the helicase protein (Nsp13) is lethal to the coronavirus infectious bronchitis virus in cultured cellsQ45412103
Mutational analysis of the SARS virus Nsp15 endoribonuclease: identification of residues affecting hexamer formationQ45423381
Further characterization of the coronavirus infectious bronchitis virus 3C-like proteinase and determination of a new cleavage site.Q45741800
Proteolytic mapping of the coronavirus infectious bronchitis virus 1b polyprotein: evidence for the presence of four cleavage sites of the 3C-like proteinase and identification of two novel cleavage productsQ45755004
Identification of a 24-kDa polypeptide processed from the coronavirus infectious bronchitis virus 1a polyprotein by the 3C-like proteinase and determination of its cleavage sitesQ45756419
Prediction of proteinase cleavage sites in polyproteins of coronaviruses and its applications in analyzing SARS-CoV genomes.Q48223031
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Formation of stable homodimer via the C-terminal alpha-helical domain of coronavirus nonstructural protein 9 is critical for its function in viral replication.Q30157460
Characterization of a torovirus main proteinaseQ30159853
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Analysis of murine hepatitis virus strain A59 temperature-sensitive mutant TS-LA6 suggests that nsp10 plays a critical role in polyprotein processingQ33281855
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Biosynthesis, Purification, and Substrate Specificity of Severe Acute Respiratory Syndrome Coronavirus 3C-like ProteinaseQ34270281
Human coronavirus 229E nonstructural protein 13: characterization of duplex-unwinding, nucleoside triphosphatase, and RNA 5'-triphosphatase activitiesQ34329485
Membrane association and dimerization of a cysteine-rich, 16-kilodalton polypeptide released from the C-terminal region of the coronavirus infectious bronchitis virus 1a polyproteinQ34340324
The arterivirus nsp4 protease is the prototype of a novel group of chymotrypsin-like enzymes, the 3C-like serine proteasesQ34377519
Discovery of an RNA virus 3'->5' exoribonuclease that is critically involved in coronavirus RNA synthesisQ34596952
Crystal structure of nonstructural protein 10 from the severe acute respiratory syndrome coronavirus reveals a novel fold with two zinc-binding motifsQ35023937
Dodecamer structure of severe acute respiratory syndrome coronavirus nonstructural protein nsp10.Q35024043
New antiviral target revealed by the hexameric structure of mouse hepatitis virus nonstructural protein nsp15.Q35024047
Construction of a severe acute respiratory syndrome coronavirus infectious cDNA clone and a replicon to study coronavirus RNA synthesis.Q35139215
Murine hepatitis virus replicase protein nsp10 is a critical regulator of viral RNA synthesisQ35857149
Proteolytic processing of the coronavirus infectious bronchitis virus 1a polyprotein: identification of a 10-kilodalton polypeptide and determination of its cleavage sitesQ35877793
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Crystal structure and mechanistic determinants of SARS coronavirus nonstructural protein 15 define an endoribonuclease familyQ36253493
High fidelity of murine hepatitis virus replication is decreased in nsp14 exoribonuclease mutants.Q36315521
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The severe acute respiratory syndrome-coronavirus replicative protein nsp9 is a single-stranded RNA-binding subunit unique in the RNA virus world.Q37094749
Major genetic marker of nidoviruses encodes a replicative endoribonucleaseQ37487223
The severe acute respiratory syndrome coronavirus Nsp15 protein is an endoribonuclease that prefers manganese as a cofactorQ37596919
Insights into SARS-CoV transcription and replication from the structure of the nsp7-nsp8 hexadecamerQ38319878
The 3C-like proteinase of an invertebrate nidovirus links coronavirus and potyvirus homologsQ38359225
Amino acid residues critical for RNA-binding in the N-terminal domain of the nucleocapsid protein are essential determinants for the infectivity of coronavirus in cultured cellsQ39080283
Viral replicase gene products suffice for coronavirus discontinuous transcriptionQ39603590
Characterization in vitro of an autocatalytic processing activity associated with the predicted 3C-like proteinase domain of the coronavirus avian infectious bronchitis virus.Q39873844
A 100-kilodalton polypeptide encoded by open reading frame (ORF) 1b of the coronavirus infectious bronchitis virus is processed by ORF 1a productsQ40041481
P433issue14
P407language of work or nameEnglishQ1860
P921main subjectbronchitisQ173022
CoronaviridaeQ1134583
infectious bronchitis virusQ69459596
P304page(s)7325-7336
P577publication date2010-05-05
P1433published inJournal of VirologyQ1251128
P1476titleFunctional and genetic studies of the substrate specificity of coronavirus infectious bronchitis virus 3C-like proteinase
P478volume84

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