A modified varying-stage adaptive phase II/III clinical trial design

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A modified varying-stage adaptive phase II/III clinical trial design is …
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scholarly articleQ13442814

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P356DOI10.1002/PST.1753
P698PubMed publication ID27264007

P50authorGaohong DongQ46433252
P2093author name stringMarc Vandemeulebroecke
P2860cites workWhen is a seamless study desirable? Case studies from different pharmaceutical sponsorsQ50116411
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Conditionally unbiased and near unbiased estimation of the selected treatment mean for multistage drop-the-losers trialsQ39961475
Adaptive seamless designs with interim treatment selection: a case study in oncologyQ41498564
Conditionally unbiased estimation in phase II/III clinical trials with early stopping for futilityQ42926272
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Shrinkage estimation in two-stage adaptive designs with midtrial treatment selectionQ43920857
An adaptive seamless phase II/III design for oncology trials with subpopulation selection using correlated survival endpointsQ44262116
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A varying-stage adaptive phase II/III clinical trial designQ44494327
A seamless phase II/III design with sample-size re-estimation.Q45342085
Dose selection in seamless phase II/III clinical trials based on efficacy and safety.Q46029341
Multiplicity adjustment for multiple endpoints in clinical trials with multiple doses of an active treatmentQ46503414
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P433issue4
P921main subjectphase II clinical trialQ42824440
phase III clinical trialQ42824827
P304page(s)368-378
P577publication date2016-06-05
P1433published inPharmaceutical StatisticsQ7180744
P1476titleA modified varying-stage adaptive phase II/III clinical trial design
P478volume15

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