Amyloid-β precursor protein induces glial differentiation of neural progenitor cells by activation of the IL-6/gp130 signaling pathway

scientific article published on 23 March 2010

Amyloid-β precursor protein induces glial differentiation of neural progenitor cells by activation of the IL-6/gp130 signaling pathway is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S12640-010-9170-6
P698PubMed publication ID20309664

P2093author name stringKiminobu Sugaya
Young-Don Kwak
Sergey Bushnev
Elise Dantuma
Stephanie Merchant
P2860cites workMolecular cloning and expression of an IL-6 signal transducer, gp130Q24328945
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Activation of JAK2 kinase mediated by the interleukin 6 signal transducer gp130Q24564280
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Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanismsQ28203690
Oncostatin M and leukemia inhibitory factor trigger overlapping and different signals through partially shared receptor complexesQ28250222
Peptides containing the RERMS sequence of amyloid beta/A4 protein precursor bind cell surface and promote neurite extensionQ28513050
Phosphorylation and internalization of gp130 occur after IL-6 activation of Jak2 kinase in hepatocytesQ28637388
Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6Q28637521
Glial fibrillary acidic protein: GFAP-thirty-one years (1969-2000).Q33923906
The development of neural stem cellsQ34100159
Neuronal target genes of the neuron-restrictive silencer factor in neurospheres derived from fetuses with Down's syndrome: a gene expression studyQ34112868
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A positive autoregulatory loop of Jak-STAT signaling controls the onset of astrogliogenesisQ34462655
Protein expression in Down syndrome brainQ34540733
Molecular mechanisms controlling cortical gliogenesisQ34671362
Gene silencing in mammals by small interfering RNAsQ34931992
The Cytokine Receptor gp130: Faithfully PromiscuousQ35541851
Secreted beta-amyloid precursor protein stimulates mitogen-activated protein kinase and enhances tau phosphorylation.Q35616076
Regulation of signal transducer and activator of transcription and suppressor of cytokine-signaling gene expression in the brain of mice with astrocyte-targeted production of interleukin-12 or experimental autoimmune encephalomyelitisQ35788671
Stage-dependent fate determination of neural precursor cells in mouse forebrain.Q36059038
Role of IL-6 in the neural stem cell differentiationQ36243978
Ligand-specific utilization of the extracellular membrane-proximal region of the gp130-related signalling receptors.Q38317255
Induction of neuroprotective kappa B-dependent transcription by secreted forms of the Alzheimer's beta-amyloid precursor.Q38354572
Characterization of astrocytes derived from human NTera-2/D1 embryonal carcinoma cellsQ40719153
Transient Notch activation initiates an irreversible switch from neurogenesis to gliogenesis by neural crest stem cellsQ40874695
Effects of acidic and basic fibroblast growth factors (aFGF, bFGF) on glial precursor cell proliferation: age dependency and brain region specificityQ41093502
Bone morphogenetic proteins induce astroglial differentiation of oligodendroglial-astroglial progenitor cellsQ41108824
In vitro differentiation of multipotent human neural progenitors in serum-free mediumQ42487414
Secreted forms of the amyloid-beta precursor protein are ligands for the class A scavenger receptor.Q43627899
Staurosporine is a potent activator of neuronal, glial, and "CNS stem cell-like" neurosphere differentiation in murine embryonic stem cellsQ44558666
Molecular genetic approach to the characterization of the "Down syndrome region" of chromosome 21.Q45829256
Evidence that embryonic neurons regulate the onset of cortical gliogenesis via cardiotrophin-1.Q46768207
Alzheimer disease--when and why?Q47714186
Amyloid precursor protein regulates differentiation of human neural stem cells.Q48469622
DNA methylation is a critical cell-intrinsic determinant of astrocyte differentiation in the fetal brain.Q48691379
Interleukin-6 signal transducer gp130 has specific binding sites for different cytokines as determined by antagonistic and agonistic anti-gp130 monoclonal antibodiesQ70911145
Timing of CNS cell generation: a programmed sequence of neuron and glial cell production from isolated murine cortical stem cellsQ73211895
Amyloid precursor protein is involved in staurosporine induced glial differentiation of neural progenitor cellsQ83114407
P433issue3-4
P407language of work or nameEnglishQ1860
P304page(s)328-338
P577publication date2010-03-23
P1433published inNeurotoxicity ResearchQ15764278
P1476titleAmyloid-β precursor protein induces glial differentiation of neural progenitor cells by activation of the IL-6/gp130 signaling pathway
P478volume18

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cites work (P2860)
Q93349952Activation of GPR55 induces neuroprotection of hippocampal neurogenesis and immune responses of neural stem cells following chronic, systemic inflammation
Q37060402GFAP expression and social deficits in transgenic mice overexpressing human sAPPα.
Q38775572Gastrodin Protects Neural Progenitor Cells Against Amyloid β (1-42)-Induced Neurotoxicity and Improves Hippocampal Neurogenesis in Amyloid β (1-42)-Injected Mice
Q39649610Involvement of notch signaling pathway in amyloid precursor protein induced glial differentiation.
Q61804428MicroRNAs as diagnostic and therapeutic tools for Alzheimer's disease: advances and limitations
Q47703114Role of Amyloid Precursor Protein (APP) and Its Derivatives in the Biology and Cell Fate Specification of Neural Stem Cells
Q33556006Staging neurodegenerative disorders: structural, regional, biomarker, and functional progressions
Q37175063The amyloid precursor protein (APP) triplicated gene impairs neuronal precursor differentiation and neurite development through two different domains in the Ts65Dn mouse model for Down syndrome

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