Genistein potentiates activity of the cation channel TRPC5 independently of tyrosine kinases.

scientific article published on 3 March 2010

Genistein potentiates activity of the cation channel TRPC5 independently of tyrosine kinases. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/J.1476-5381.2010.00636.X
P932PMC publication ID2850405
P698PubMed publication ID20233211
P5875ResearchGate publication ID42108294

P50authorYu HuangQ56528909
Xiaoqiang YaoQ57009857
P2093author name stringChing-On Wong
P2860cites workTRPC channel activation by extracellular thioredoxinQ24650851
TRPC5 is a regulator of hippocampal neurite length and growth cone morphologyQ28186910
Phytochemical genistein in the regulation of vascular function: new insightsQ28255853
Canonical transient receptor potential channels promote cardiomyocyte hypertrophy through activation of calcineurin signalingQ28261648
Evaluation of ligand selectivity using reporter cell lines stably expressing estrogen receptor alpha or betaQ28303271
Genistein, a specific inhibitor of tyrosine-specific protein kinasesQ29618097
Complex functions of phosphatidylinositol 4,5-bisphosphate in regulation of TRPC5 cation channelsQ33573380
Isoflavonoids and chronic disease: mechanisms of actionQ34160721
Rapid actions of plasma membrane estrogen receptorsQ34214352
Role of Src in C3 transient receptor potential channel function and evidence for a heterogeneous makeup of receptor- and store-operated Ca2+ entry channelsQ34249717
Block of TRPC5 channels by 2-aminoethoxydiphenyl borate: a differential, extracellular and voltage-dependent effectQ34408366
Canonical transient receptor potential 5.Q34600602
Bipolar phospholipid sensing by TRPC5 calcium channel.Q34603424
Estrogen and xenoestrogen actions on endocrine pancreas: from ion channel modulation to activation of nuclear function.Q35853377
Recent developments in vascular endothelial cell transient receptor potential channelsQ36299266
Regulation of canonical transient receptor potential isoform 3 (TRPC3) channel by protein kinase G.Q36603171
Rapid estrogen signaling in the brainQ37078034
Epinephrine-induced Ca2+ influx in vascular endothelial cells is mediated by CNGA2 channels.Q39962254
Sensing of lysophospholipids by TRPC5 calcium channelQ40337792
Human TRPC5 channel activated by a multiplicity of signals in a single cellQ40535856
Lanthanides potentiate TRPC5 currents by an action at extracellular sites close to the pore mouthQ40686893
Receptor-mediated regulation of the nonselective cation channels TRPC4 and TRPC5.Q40876055
Genistein inhibits cardiac L-type Ca(2+) channel activity by a tyrosine kinase-independent mechanismQ42524881
Intracellular calcium strongly potentiates agonist-activated TRPC5 channels.Q42548715
A sphingosine-1-phosphate-activated calcium channel controlling vascular smooth muscle cell motilityQ43138558
Inhibitory effects of genistein on ATP-sensitive K+ channels in rabbit portal vein smooth muscleQ43179252
Genistein inhibits the inward rectifying potassium current in guinea pig ventricular myocytesQ44081309
Genistein Can Modulate Channel Function by a Phosphorylation-Independent Mechanism: Importance of Hydrophobic Mismatch and Bilayer MechanicsQ44657959
Genistein directly inhibits L-type calcium currents but potentiates cAMP-dependent chloride currents in cardiomyocytesQ46157689
CNGA2 channels mediate adenosine-induced Ca2+ influx in vascular endothelial cells.Q46739960
Generation of functional ion-channel tools by E3 targeting.Q51353260
Tyrosine kinase inhibitors suppress N-type and T-type Ca2+ channel currents in NG108-15 cells.Q51515370
E3-targeted anti-TRPC5 antibody inhibits store-operated calcium entry in freshly isolated pial arterioles.Q52855490
Transient receptor potential channels in essential hypertension.Q52933025
Guide to Receptors and Channels (GRAC), 4th EditionQ56639335
Modulation of Liposomal Membrane Fluidity by Flavonoids and IsoflavonoidsQ59281335
Inhibition of vascular smooth muscle cell K+ currents by tyrosine kinase inhibitors genistein and ST 638Q72455594
Direct block of voltage-sensitive sodium channels by genistein, a tyrosine kinase inhibitorQ73045752
Regulation of TRP channel TRPM2 by the tyrosine phosphatase PTPL1Q79654779
Interactions of genistein and related isoflavones with lipid micellesQ80069271
P433issue7
P407language of work or nameEnglishQ1860
P304page(s)1486-1496
P577publication date2010-03-03
P1433published inBritish Journal of PharmacologyQ919631
P1476titleGenistein potentiates activity of the cation channel TRPC5 independently of tyrosine kinases
P478volume159

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cites work (P2860)
Q37220799Aortic Baroreceptors Display Higher Mechanosensitivity than Carotid Baroreceptors
Q36153290Apigenin, a plant-derived flavone, activates transient receptor potential vanilloid 4 cation channel.
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Q44207548Genistein excitation of gonadotrophin-releasing hormone neurones in juvenile female mice
Q38114119In pursuit of small molecule chemistry for calcium-permeable non-selective TRPC channels -- mirage or pot of gold?
Q35780729Insulin increases surface expression of TRPC6 channels in podocytes: role of NADPH oxidases and reactive oxygen species
Q93551704Ion Channels
Q54360230Mg²⁺-dependent modulation of BKCa channels by genistein in rat arteriolar smooth muscle cells.
Q40324920Natural and synthetic flavonoid modulation of TRPC5 channels
Q39715069Nitric oxide lacks direct effect on TRPC5 channels but suppresses endogenous TRPC5-containing channels in endothelial cells
Q47325822Noradrenaline Modulates the Membrane Potential and Holding Current of Medial Prefrontal Cortex Pyramidal Neurons via β1-Adrenergic Receptors and HCN Channels.
Q35596439Plasma membrane mechanical stress activates TRPC5 channels
Q37835328Properties and therapeutic potential of transient receptor potential channels with putative roles in adversity: focus on TRPC5, TRPM2 and TRPA1.
Q39080963Riluzole activates TRPC5 channels independently of PLC activity
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Q36170493Update on vascular endothelial Ca(2+) signalling: A tale of ion channels, pumps and transporters

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