A flavivirus signal peptide balances the catalytic activity of two proteases and thereby facilitates virus morphogenesis

scientific article

A flavivirus signal peptide balances the catalytic activity of two proteases and thereby facilitates virus morphogenesis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.VIROL.2010.02.008
P698PubMed publication ID20207389
P5875ResearchGate publication ID41808024

P50authorEva K. LeeQ75682803
P2093author name stringMario Lobigs
Megan Pavy
Päivi Lobigs
Mah Lee Ng
P2860cites workAntiviral effect of the heparan sulfate mimetic, PI-88, against dengue and encephalitic flavivirusesQ40347293
Murray Valley encephalitis virus field strains from Australia and Papua New Guinea: studies on the sequence of the major envelope protein gene and virulence for miceQ40785472
Studies on the nature of dengue viruses. IV. The structural proteins of type 2 dengue virusQ40936964
Proteolytic processing of a Murray Valley encephalitis virus non-structural polyprotein segment containing the viral proteinase: accumulation of a NS3-4A precursor which requires mature NS3 for efficient processingQ42981986
Genetic differentiation of Murray Valley encephalitis virus in Australia and Papua New Guinea.Q42991076
In situ reactions of monoclonal antibodies with a viable mutant of Murray Valley encephalitis virus reveal an absence of dimeric NS1 proteinQ43036631
Regulation of the late events in flavivirus protein processing and maturationQ43047637
Role of type I and type II interferon responses in recovery from infection with an encephalitic flavivirusQ43049528
Functional role of type I and type II interferons in antiviral defenseQ24276429
Structure of dengue virus: implications for flavivirus organization, maturation, and fusionQ24736810
Substitutions at the putative receptor-binding site of an encephalitic flavivirus alter virulence and host cell tropism and reveal a role for glycosaminoglycans in entryQ27469309
Signal peptidase cleavage at the flavivirus C-prM junction: dependence on the viral NS2B-3 protease for efficient processing requires determinants in C, the signal peptide, and prMQ27469528
Mutagenesis of the signal sequence of yellow fever virus prM protein: enhancement of signalase cleavage In vitro is lethal for virus productionQ27469616
Stable high-level expression of heterologous genes in vitro and in vivo by noncytopathic DNA-based Kunjin virus replicon vectorsQ27469662
Mutagenesis of the NS2B-NS3-mediated cleavage site in the flavivirus capsid protein demonstrates a requirement for coordinated processingQ27469726
Coupling between replication and packaging of flavivirus RNA: evidence derived from the use of DNA-based full-length cDNA clones of Kunjin virusQ27469797
Alpha/beta interferon protects against lethal West Nile virus infection by restricting cellular tropism and enhancing neuronal survivalQ27472671
Lack of both Fas ligand and perforin protects from flavivirus-mediated encephalitis in miceQ27472849
Complementation analysis of the flavivirus Kunjin NS3 and NS5 proteins defines the minimal regions essential for formation of a replication complex and shows a requirement of NS3 in cis for virus assemblyQ27472910
Structures of immature flavivirus particlesQ27477478
Translation of the Flavivirus Kunjin NS3 Gene in cis but Not Its RNA Sequence or Secondary Structure Is Essential for Efficient RNA PackagingQ27477616
Incorporation of Tick-Borne Encephalitis Virus Replicons into Virus-Like Particles by a Packaging Cell LineQ27477708
Construction and Mutagenesis of an Artificial Bicistronic Tick-Borne Encephalitis Virus Genome Reveals an Essential Function of the Second Transmembrane Region of Protein E in Flavivirus AssemblyQ27477719
Posttranslational signal peptidase cleavage at the flavivirus C-prM junction in vitroQ27480321
Yellow Fever Virus NS3 Plays an Essential Role in Virus Assembly Independent of Its Known Enzymatic FunctionsQ27485572
NS2B-3 proteinase-mediated processing in the yellow fever virus structural region: in vitro and in vivo studiesQ27485989
E Protein Domain III Determinants of Yellow Fever Virus 17D Vaccine Strain Enhance Binding to Glycosaminoglycans, Impede Virus Spread, and Attenuate VirulenceQ27486116
Production and characterization of vaccines based on flaviviruses defective in replicationQ27486374
Extension of Flavivirus Protein C Differentially Affects Early RNA Synthesis and Growth in Mammalian and Arthropod Host CellsQ27490326
Physical and biological properties of dengue-2 virus and associated antigensQ30501192
How proteins adapt to a membrane-water interfaceQ34023262
Tetracycline-inducible packaging cell line for production of flavivirus replicon particlesQ34552578
Inefficient signalase cleavage promotes efficient nucleocapsid incorporation into budding flavivirus membranesQ34553454
Common E protein determinants for attenuation of glycosaminoglycan-binding variants of Japanese encephalitis and West Nile virusesQ35702608
Flavivirus premembrane protein cleavage and spike heterodimer secretion require the function of the viral proteinase NS3.Q36400767
Mimicking live flavivirus immunization with a noninfectious RNA vaccineQ36604221
trans-Packaged West Nile virus-like particles: infectious properties in vitro and in infected mosquito vectorsQ37583440
The signal peptideQ37942677
Epitope Analysis of the Envelope and Non-structural Glycoproteins of Murray Valley Encephalitis VirusQ39042221
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectmorphogenesisQ815547
P304page(s)80-89
P577publication date2010-03-06
P1433published inVirologyQ7934867
P1476titleA flavivirus signal peptide balances the catalytic activity of two proteases and thereby facilitates virus morphogenesis
P478volume401

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cites work (P2860)
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