The Hsp70 and TRiC/CCT chaperone systems cooperate in vivo to assemble the von Hippel-Lindau tumor suppressor complex

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The Hsp70 and TRiC/CCT chaperone systems cooperate in vivo to assemble the von Hippel-Lindau tumor suppressor complex is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.23.9.3141-3151.2003
P932PMC publication ID153194
P698PubMed publication ID12697815
P5875ResearchGate publication ID7498035

P50authorAnne S MeyerQ59542682
Judith FrydmanQ61960999
P2093author name stringMark W Melville
Amie J McClellan
Andre Darveau
P2860cites workThe tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysisQ22009936
HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensingQ24291102
Functional organization of the yeast proteome by systematic analysis of protein complexesQ24292209
Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperoninQ24336409
The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteinsQ24564802
Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complexQ24654714
Studying interactions of four proteins in the yeast two-hybrid system: structural resemblance of the pVHL/elongin BC/hCUL-2 complex with the ubiquitin ligase complex SKP1/cullin/F-box proteinQ24657293
Solution structure and dynamics of yeast elongin C in complex with a von Hippel-Lindau peptideQ27634727
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylationQ27860876
Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometryQ27861116
Functional interaction of cytosolic hsp70 and a DnaJ-related protein, Ydj1p, in protein translocation in vivoQ27935347
Folding in vivo of a newly translated yeast cytosolic enzyme is mediated by the SSA class of cytosolic yeast Hsp70 proteinsQ27935523
Compartmentation of protein folding in vivo: sequestration of non-native polypeptide by the chaperonin-GimC systemQ27937256
Molecular evolution of the HSP70 multigene familyQ27940113
Protein misfolding, evolution and diseaseQ28143452
The von Hippel-Lindau tumor suppressor geneQ28203455
Molecular chaperones in the cytosol: from nascent chain to folded proteinQ28205903
Principles of chaperone-assisted protein folding: differences between in vitro and in vivo mechanismsQ28279173
Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligaseQ28506124
The Hsp70 and Hsp60 chaperone machinesQ29547601
Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau proteinQ29615928
Folding of newly translated proteins in vivo: the role of molecular chaperonesQ29619368
Molecular cloning of DNAs encoding the regulatory subunits of elongin from Saccharomyces cerevisiae and Drosophila melanogasterQ32152292
Formation of the VHL-elongin BC tumor suppressor complex is mediated by the chaperonin TRiC.Q33886538
Getting newly synthesized proteins into shape.Q33901641
Defective folding and rapid degradation of mutant proteins is a common disease mechanism in genetic disordersQ34006948
Von Hippel-Lindau disease: clinical and molecular perspectivesQ34305239
Diverse effects of mutations in exon II of the von Hippel-Lindau (VHL) tumor suppressor gene on the interaction of pVHL with the cytosolic chaperonin and pVHL-dependent ubiquitin ligase activityQ34323668
Review: cellular substrates of the eukaryotic chaperonin TRiC/CCT.Q34387488
The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activityQ35201819
A yeast TCP-1-like protein is required for actin function in vivoQ35763868
Sequential action of mitochondrial chaperones in protein import into the matrixQ35933138
Elongin BC complex prevents degradation of von Hippel-Lindau tumor suppressor gene productsQ37230912
In vivo newly translated polypeptides are sequestered in a protected folding environmentQ40983488
Review: the Cct eukaryotic chaperonin subunits of Saccharomyces cerevisiae and other yeastsQ41083231
Chaperones get in touch: the Hip-Hop connectionQ41379488
Increased proportion of B cell hybridomas secreting monoclonal antibodies of desired specificity in cultures containing macrophage-derived hybridoma growth factor (IL-6).Q46091038
Trigger factor and DnaK cooperate in folding of newly synthesized proteins.Q54081409
Sequential interaction of the chaperones BiP and GRP94 with immunoglobulin chains in the endoplasmic reticulumQ59060210
Folding of nascent polypeptide chains in a high molecular mass assembly with molecular chaperonesQ59060241
Folding of VSV G protein: sequential interaction with BiP and calnexinQ72752117
Novel roles for elongin C in yeastQ73666190
Directionality of polypeptide transfer in the mitochondrial pathway of chaperone-mediated protein foldingQ74490317
Polypeptide flux through bacterial Hsp70: DnaK cooperates with trigger factor in chaperoning nascent chainsQ77918974
Copper ion inducible and repressible promoter systems in yeastQ78083803
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectmolecular chaperonesQ422496
P304page(s)3141-3151
P577publication date2003-05-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleThe Hsp70 and TRiC/CCT chaperone systems cooperate in vivo to assemble the von Hippel-Lindau tumor suppressor complex
P478volume23

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