Rac1 is required for oncolytic NDV replication in human cancer cells and establishes a link between tumorigenesis and sensitivity to oncolytic virus

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Rac1 is required for oncolytic NDV replication in human cancer cells and establishes a link between tumorigenesis and sensitivity to oncolytic virus is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/ONC.2009.507
P8608Fatcat IDrelease_euztqblydbhjhmx656gszx6vom
P698PubMed publication ID20101224

P2093author name stringD Mumberg
P Boukamp
R Beier
J Puhlmann
F Puehler
P2860cites workThe molecular basis of viral oncolysis: usurpation of the Ras signaling pathway by reovirusQ24533256
Phosphoinositide-3 Kinase-Akt Pathway Controls Cellular Entry of Ebola VirusQ27486638
Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteinsQ27860890
How cells respond to interferonsQ27861006
Roles of the Rac1 and Rac3 GTPases in human tumor cell invasionQ28262533
Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell lineQ29547520
Rational design and characterization of a Rac GTPase-specific small molecule inhibitorQ29616494
Newcastle disease virus (NDV): brief history of its oncolytic strainsQ33841589
Exploiting tumor-specific defects in the interferon pathway with a previously unknown oncolytic virusQ33908950
Activated MEK suppresses activation of PKR and enables efficient replication and in vivo oncolysis by Deltagamma(1)34.5 mutants of herpes simplex virus 1Q34302130
Differentially regulated interferon response determines the outcome of Newcastle disease virus infection in normal and tumor cell linesQ34648125
Ras proteins: different signals from different locationsQ35120159
A critical role for Rac1 in tumor progression of human colorectal adenocarcinoma cellsQ36357411
Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformationQ36556010
Reovirus oncolysis: the Ras/RalGEF/p38 pathway dictates host cell permissiveness to reovirus infectionQ37285576
Rac1 GTPase: a "Rac" of all trades.Q37371665
Newcastle disease virus: a promising vector for viral therapy, immune therapy, and gene therapy of cancerQ37535829
Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformationQ38334837
Signals from the Ras, Rac, and Rho GTPases converge on the Pak protein kinase in Rat-1 fibroblastsQ39444795
Bioselection of a gain of function mutation that enhances adenovirus 5 release and improves its antitumoral potency.Q39923110
Generation of a recombinant oncolytic Newcastle disease virus and expression of a full IgG antibody from two transgenesQ40024329
The RAS/Raf1/MEK/ERK signaling pathway facilitates VSV-mediated oncolysis: implication for the defective interferon response in cancer cellsQ40132472
Early herpes simplex virus type 1 infection is dependent on regulated Rac1/Cdc42 signalling in epithelial MDCKII cellsQ40209381
Tumor selective replication of Newcastle disease virus: association with defects of tumor cells in antiviral defenceQ40318115
The role of Rac1 in maintaining malignant phenotype of mouse skin tumor cellsQ40422550
Oncogenes in Ras signalling pathway dictate host-cell permissiveness to herpes simplex virus 1.Q40788613
Multiple stages and genetic alterations in immortalization, malignant transformation, and tumor progression of human skin keratinocytesQ40991506
CDC42 and Rac1 are implicated in the activation of the Nef-associated kinase and replication of HIV-1.Q41147249
Defective translational control facilitates vesicular stomatitis virus oncolysisQ42831942
Tumor progression of skin carcinoma cells in vivo promoted by clonal selection, mutagenesis, and autocrine growth regulation by granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factorQ42856274
OBSERVATIONS ON THE REPEATED ADMINISTRATION OF VIRUSES TO A PATIENT WITH ACUTE LEUKEMIA. A PRELIMINARY REPORT.Q43786318
An optimized clinical regimen for the oncolytic virus PV701.Q45407407
NEWCASTLE DISEASE VIRUS AS AN ANTINEOPLASTIC AGENT.Q45713156
Phase I trial of intravenous administration of PV701, an oncolytic virus, in patients with advanced solid cancersQ45732737
Newcastle disease virus selectively kills human tumor cellsQ45865340
Requirement for Rac1 in a K-ras induced lung cancer in the mouseQ53329326
Rho GTPase activity modulates paramyxovirus fusion protein-mediated cell–cell fusionQ56912219
P433issue15
P407language of work or nameEnglishQ1860
P921main subjectoncolytic virusQ1560099
P304page(s)2205-2216
P577publication date2010-01-25
P1433published inOncogeneQ1568657
P1476titleRac1 is required for oncolytic NDV replication in human cancer cells and establishes a link between tumorigenesis and sensitivity to oncolytic virus
P478volume29