Functional characterization of high levels of meningioma 1 as collaborating oncogene in acute leukemia

scientific article

Functional characterization of high levels of meningioma 1 as collaborating oncogene in acute leukemia is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/LEU.2009.272
P698PubMed publication ID20072157
P5875ResearchGate publication ID41013432

P2093author name stringV Rossi
T Liu
A Biondi
J Schwaller
D Jankovic
F Baty
S Ehret
L Brault
V Stavropoulou
P2860cites workPrognostic importance of MN1 transcript levels, and biologic insights from MN1-associated gene and microRNA expression signatures in cytogenetically normal acute myeloid leukemia: a cancer and leukemia group B studyQ24643738
MN1, a novel player in human AMLQ24653588
MN1-TEL myeloid oncoprotein expressed in multipotent progenitors perturbs both myeloid and lymphoid growth and causes T-lymphoid tumors in miceQ24669642
Conditional MN1-TEL knock-in mice develop acute myeloid leukemia in conjunction with overexpression of HOXA9Q24669668
High EVI1 expression predicts poor survival in acute myeloid leukemia: a study of 319 de novo AML patientsQ28209409
MLL translocations, histone modifications and leukaemia stem-cell developmentQ29615368
Candidate genes for expansion and transformation of hematopoietic stem cells by NUP98-HOX fusion genesQ33294832
Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENLQ33887064
Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genesQ33889476
MN1 overexpression induces acute myeloid leukemia in mice and predicts ATRA resistance in patients with AML.Q34627288
MN1 overexpression is an important step in the development of inv(16) AML.Q34631634
Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitorsQ34641731
Insertional mutagenesis identifies genes that promote the immortalization of primary bone marrow progenitor cellsQ35847760
Cooperating cancer-gene identification through oncogenic-retrovirus-induced insertional mutagenesisQ35848246
The molecular basis of leukemiaQ35961770
Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential.Q36098242
ReSETting PP2A tumour suppressor activity in blast crisis and imatinib-resistant chronic myelogenous leukaemiaQ36585748
Retroviral insertion mutagenesis in mice as a comparative oncogenomics tool to identify disease genes in human leukemiaQ36681931
Malignant transformation initiated by Mll-AF9: gene dosage and critical target cellsQ36726183
N-Glycans in cancer progressionQ37243167
Genome-wide identification of aberrantly methylated promoter associated CpG islands in acute lymphocytic leukemia.Q39975102
Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia.Q40219637
Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9.Q40252270
Suppressor of cytokine signalling-1 gene silencing in acute myeloid leukaemia and human haematopoietic cell linesQ40522793
Retroviral insertional mutagenesis identifies genes that collaborate with NUP98-HOXD13 during leukemic transformation.Q42185555
AML1 mutations induced MDS and MDS/AML in a mouse BMT modelQ42818187
Significance of heat-shock protein (HSP) 90 expression in acute myeloid leukemia cellsQ42970606
High meningioma 1 (MN1) expression as a predictor for poor outcome in acute myeloid leukemia with normal cytogeneticsQ44034346
Prognostically useful gene-expression profiles in acute myeloid leukemiaQ51999490
Acute myeloid leukemia induced by MLL-ENL is cured by oncogene ablation despite acquisition of complex genetic abnormalitiesQ53315688
MN1-TEL, the product of the t(12;22) in human myeloid leukemia, immortalizes murine myeloid cells and causes myeloid malignancy in mice.Q53344487
MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors.Q53362332
The MLL recombinome of acute leukemiasQ56965972
Significance of murine retroviral mutagenesis for identification of disease genes in human acute myeloid leukemiaQ82310130
P433issue3
P921main subjectcollaborationQ1145523
leukemiaQ29496
P304page(s)601-612
P577publication date2010-01-14
P1433published inLeukemiaQ6534498
P1476titleFunctional characterization of high levels of meningioma 1 as collaborating oncogene in acute leukemia
P478volume24

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cites work (P2860)
Q35995227An insertional mutagenesis screen identifies genes that cooperate with Mll-AF9 in a murine leukemogenesis model
Q45990007CXCR4-SERINE339 regulates cellular adhesion, retention and mobilization, and is a marker for poor prognosis in acute myeloid leukemia.
Q35425688Cell fate decisions in malignant hematopoiesis: leukemia phenotype is determined by distinct functional domains of the MN1 oncogene
Q38262122Cell of origin in AML: susceptibility to MN1-induced transformation is regulated by the MEIS1/AbdB-like HOX protein complex
Q34474749Cell population-specific expression analysis of human cerebellum
Q38981878Constitutive IRF8 expression inhibits AML by activation of repressed immune response signaling
Q96640393Effective drug treatment identified by in vivo screening in a transplantable patient-derived xenograft model of chronic myelomonocytic leukemia
Q37818094Epigenetic Mechanisms in Acute Myeloid Leukemia
Q37499049High MN1 expression increases the in vitro clonogenic activity of primary mouse B-cells
Q44738170Impairing MLL-fusion gene-mediated transformation by dissecting critical interactions with the lens epithelium-derived growth factor (LEDGF/p75).
Q34692292Mapping of MN1 Sequences Necessary for Myeloid Transformation
Q47117304Meis2 as a critical player in MN1-induced leukemia.
Q46570611Meningioma 1 (MN1) expression: Refined risk stratification in acute myeloid leukemia with normal cytogenetics (CN-AML)
Q38432673Modeling de novo leukemogenesis from human cord blood with MN1 and NUP98HOXD13
Q47255841Myeloid neoplasms with t(12;22)(p13;q12)/MN1-EVT6: a systematic review of 12 cases.
Q28482247Overexpression of MN1 Confers Resistance to Chemotherapy, Accelerates Leukemia Onset, and Suppresses p53 and Bim Induction
Q37524210Positive feedback between NF-κB and TNF-α promotes leukemia-initiating cell capacity
Q36036310Potent co-operation between the NUP98-NSD1 fusion and the FLT3-ITD mutation in acute myeloid leukemia induction
Q94482231Role of Meningioma 1 for maintaining the transformed state in MLL-rearranged acute myeloid leukemia: potential for therapeutic intervention?
Q30250315Significance of oncogenes and tumor suppressor genes in AML prognosis.
Q42143905The Meningioma 1 (MN1) Gene is an Independent Poor Prognostic Factor in Adult Egyptian Acute Myeloid Leukemia Patients
Q51890625Transcriptional deregulation of oncogenic myocyte enhancer factor 2C in T-cell acute lymphoblastic leukemia
Q35885311Unique dual targeting of thymidylate synthase and topoisomerase1 by FdUMP[10] results in high efficacy against AML and low toxicity

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