Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease.

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Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/AAC.47.6.2047-2050.2003
P932PMC publication ID155860
P698PubMed publication ID12760897
P5875ResearchGate publication ID10748333

P50authorJuan B. RodríguezQ55762175
P2093author name stringJulio A Urbina
Roberto Docampo
Andrea Montalvetti
Juan Luis Concepcion
P2860cites workAntiproliferative effects and mechanism of action of SCH 56592 against Trypanosoma (Schizotrypanum) cruzi: in vitro and in vivo studies.Q33694317
Squalene synthase as a chemotherapeutic target in Trypanosoma cruzi and Leishmania mexicanaQ34162880
Recent developments in the chemotherapy of Chagas disease.Q34319202
Chemotherapy of Chagas diseaseQ34541660
Specific treatment of Chagas disease: current status and new developmentsQ34608380
Effects of juvenile hormone on mammalian steroidogenesisQ41450426
Lipid biosynthesis pathways as chemotherapeutic targets in kinetoplastid parasitesQ41601456
Development of a radiometric spot-wash assay for squalene synthaseQ41954359
Synthesis and activity of a novel series of 3-biarylquinuclidine squalene synthase inhibitorsQ42555302
YM-53601, a novel squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in several animal speciesQ43264545
Bisphosphonates are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthaseQ43660559
Recombinant squalene synthase. Synthesis of non-head-to-tail isoprenoids in the absence of NADPH.Q44076633
Recombinant squalene synthase. A mechanism for the rearrangement of presqualene diphosphate to squaleneQ44076636
Design, synthesis, and biological evaluation of aryloxyethyl thiocyanate derivatives against Trypanosoma cruziQ44110808
Squalene synthase: steady-state, pre-steady-state, and isotope-trapping studies.Q55033631
Cure of short- and long-term experimental Chagas' disease using D0870Q58843324
Structure−Activity Relationship of New Growth Inhibitors ofTrypanosomacruziQ58866773
Trypanosoma (Schizotrypanum) cruzi: terminal oxidases in exponential and stationary growth phase emipastigotes cultured in vitroQ70406315
Modification of the sterol composition of Trypanosoma (Schizotrypanum) cruzi epimastigotes by delta 24(25)-sterol methyl transferase inhibitors and their combinations with ketoconazoleQ70940460
Inhibition of squalene synthase in vitro by 3-(biphenyl-4-yl)-quinuclidineQ71077795
Regulation of the cholesterol ester cycle and progesterone synthesis by juvenile hormone in MA-10 Leydig tumor cellsQ72550267
3-Hydroxy-3-methyl-glutaryl-CoA reductase in Trypanosoma (Schizotrypanum) cruzi: subcellular localization and kinetic propertiesQ74378292
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectChagas diseaseQ649558
Trypanosoma cruziQ150162
P304page(s)2047-2050
P577publication date2003-06-01
P1433published inAntimicrobial Agents and ChemotherapyQ578004
P1476titleMechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease
P478volume47

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cites work (P2860)
Q38938937Activity of Fluorine-Containing Analogues of WC-9 and Structurally Related Analogues against Two Intracellular Parasites: Trypanosoma cruzi and Toxoplasma gondii.
Q92610556Advances in preclinical approaches to Chagas disease drug discovery
Q35660950Aryloxyethyl Thiocyanates Are Potent Growth Inhibitors of Trypanosoma cruzi and Toxoplasma gondii.
Q36795395Cardiac manifestations of parasitic infections part 1: overview and immunopathogenesis.
Q37318751Design, synthesis and biological evaluation of WC-9 analogs as antiparasitic agents
Q38845466Detection and treatment of Trypanosoma cruzi: a patent review (2011-2015).
Q43276756Ergosterol biosynthesis and drug development for Chagas disease
Q37254812Fluorine-containing aryloxyethyl thiocyanate derivatives are potent inhibitors of Trypanosoma cruzi and Toxoplasma gondii proliferation
Q91941849Further insights of selenium-containing analogues of WC-9 against Trypanosoma cruzi
Q27678389Head-to-Head Prenyl Tranferases: Anti-Infective Drug Targets
Q37612993In Vitro and In Vivo Activities of Sulfur-Containing Linear Bisphosphonates against Apicomplexan Parasites
Q35125554In vitro and in vivo activities of E5700 and ER-119884, two novel orally active squalene synthase inhibitors, against Trypanosoma cruzi
Q79416088Inhibitory effect of umbelliferone aminoalkyl derivatives on oxidosqualene cyclases from S. cerevisiae, T. cruzi, P. carinii, H. sapiens, and A. thaliana: a structure-activity study
Q37992089New antibacterials for the treatment of toxoplasmosis; a patent review
Q28554785Quantitative Laser Biospeckle Method for the Evaluation of the Activity of Trypanosoma cruzi Using VDRL Plates and Digital Analysis
Q27683611Squalene synthase as a target for Chagas disease therapeutics
Q36580508Synthesis and biological evaluation of 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase
Q34764622Synthesis and biological evaluation of new 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase.
Q33290749Synthesis, Cruzain docking, and in vitro studies of aryl-4-oxothiazolylhydrazones against Trypanosoma cruzi
Q38974228Synthetic Medicinal Chemistry in Chagas' Disease: Compounds at The Final Stage of "Hit-To-Lead" Phase
Q35022297Toxoplasma gondii relies on both host and parasite isoprenoids and can be rendered sensitive to atorvastatin

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