Bisphosphonates: mechanisms of action

scientific article

Bisphosphonates: mechanisms of action is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1172/JCI118722
P932PMC publication ID507360
P698PubMed publication ID8675678

P2093author name stringRodan GA
Fleisch HA
P2860cites workHuman protein tyrosine phosphatase-sigma: alternative splicing and inhibition by bisphosphonatesQ28301020
Bisphosphonates act on rat bone resorption through the mediation of osteoblastsQ33898760
The effects of 2-year treatment with the aminobisphosphonate alendronate on bone metabolism, bone histomorphometry, and bone strength in ovariectomized nonhuman primatesQ33909532
Bisphosphonate action. Alendronate localization in rat bone and effects on osteoclast ultrastructureQ34216753
Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone in miceQ35607627
Effect of bisphosphonates on proliferation and viability of mouse bone marrow-derived macrophagesQ36458021
Protein-tyrosine phosphatase activity regulates osteoclast formation and function: inhibition by alendronateQ37685549
The effect of several diphosphonates on acid phosphohydrolases and other lysosomal enzymesQ39983345
Renal secretion of diphosphonates in ratsQ40338996
Inhibition of osteoclast-like cell formation by bisphosphonates in long-term cultures of human bone marrow.Q40379763
The when and how of Src regulationQ40487537
Clinical effects of bisphosphonates in involutional osteoporosisQ40721873
A new model for the regulation of bone resorption, with particular reference to the effects of bisphosphonatesQ41122422
Bisphosphonates induce osteoblasts to secrete an inhibitor of osteoclast-mediated resorptionQ41196903
Importance of the paracellular pathway for the transport of a new bisphosphonate using the human CACO-2 monolayers modelQ41514890
The influence of 1-hydroxyethane-1,1-diphosphonate and dichloromethanediphosphonate on lysine hydroxylation and cross-link formation in rat bone, cartilage and skin collagenQ42022377
Structure-activity relationships of various bisphosphonatesQ42259282
A possible mechanism of the specific action of bisphosphonates on osteoclasts: tiludronate preferentially affects polarized osteoclasts having ruffled bordersQ42557625
Acid extrusion is induced by osteoclast attachment to bone. Inhibition by alendronate and calcitoninQ42930218
The effects of diphosphonates on the growth and glycolysis of connective-tissue cells in cultureQ42935477
Two modes of action of bisphosphonates on osteoclastic resorption of mineralized matrixQ44274641
The binding of pyrophosphate and two diphosphonates by hydroxyapatite crystalsQ44967804
Four-year study of intermittent cyclic etidronate treatment of postmenopausal osteoporosis: three years of blinded therapy followed by one year of open therapy.Q45976835
Effect of ethane-1-hydroxy-1,1-diphosphonate (EHDP) and dichloromethylene diphosphonate (Cl 2 MDP) on the calcification and resorption of cartilage and bone in the tibial epiphysis and metaphysis of ratsQ46282954
Effects of two novel bisphosphonates on bone cells in vitroQ47561419
Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis. The Alendronate Phase III Osteoporosis Treatment Study GroupQ48527134
Bisphosphonates act on osteoblastic cells and inhibit osteoclast formation in mouse marrow cultures.Q54153483
Diphosphonates inhibit formation of calcium phosphate crystals in vitro and pathological calcification in vivo.Q54724724
Effects of bisphosphonates on isolated rat osteoclasts as examined by reflected light microscopyQ57104134
Intermittent cyclical etidronate treatment of postmenopausal osteoporosisQ67300571
Retention of etidronate in human, dog, and ratQ68178967
The subcellular distribution of [14C]dichloromethylenebisphosphonate and [14C]1-hydroxyethylidene-1,1-bisphosphonate in cultured calvaria cellsQ70196013
The acute-phase response after bisphosphonate administrationQ70376821
The influence of two diphosphonates on calcium metabolism in the ratQ70411015
Changes in bone histomorphometry after long-term treatment with intermittent, cyclic etidronate for postmenopausal osteoporosisQ70583314
Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivoQ71207806
Influence of a diphosphonate on the cellular aspect of young bone tissueQ71520540
Interleukin-6 and the acute phase response during treatment of patients with Paget's disease with the nitrogen-containing bisphosphonate dimethylaminohydroxypropylidene bisphosphonateQ71773706
The effects of risedronate on canine cancellous bone remodeling: three-dimensional kinetic reconstruction of the remodeling siteQ72248081
Alendronate distributed on bone surfaces inhibits osteoclastic bone resorption in vitro and in experimental hypercalcemia modelsQ72251064
Diphosphonates inhibit hydroxyapatite dissolution in vitro and bone resorption in tissue culture and in vivoQ72434479
Lipophilic 1,1-bisphosphonates are potent squalene synthase inhibitors and orally active cholesterol lowering agents in vivoQ72571828
Inhibitory effects of bisphosphonates on growth of amoebae of the cellular slime mold Dictyostelium discoideumQ72758768
Effects of one-year cyclical treatment with clodronate on postmenopausal bone lossQ72838186
Continuous therapy with pamidronate, a potent bisphosphonate, in postmenopausal osteoporosisQ72879073
Studies on x ray absorption and diffraction of bone tissueQ76137662
P433issue12
P407language of work or nameEnglishQ1860
P304page(s)2692-2696
P577publication date1996-06-01
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleBisphosphonates: mechanisms of action.
P478volume97

Reverse relations

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