[11C]AF150(S), an agonist PET ligand for M1 muscarinic acetylcholine receptors

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[11C]AF150(S), an agonist PET ligand for M1 muscarinic acetylcholine receptors is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1001260312
P356DOI10.1186/2191-219X-3-19
P932PMC publication ID3623648
P698PubMed publication ID23514539

P50authorAdriaan A LammertsmaQ52983347
Hans J C BuiterQ90963203
Maqsood YaqubQ92663723
Josée E LeysenQ117267565
Albert D. WindhorstQ39190002
P2093author name stringMarc C Huisman
Dirk L Knol
Abraham Fisher
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AF150(S): A new functionally selective M1 agonist improves cognitive performance in ratsQ48799211
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Xanomeline, an M(1)/M(4) preferring muscarinic cholinergic receptor agonist, produces antipsychotic-like activity in rats and mice.Q52168809
Gender differences in the effect of rivastigmine on brain cholinesterase activity and cognitive function in rats.Q52170510
Effect of L-dopa and 6-hydroxydopamine lesioning on [11C]raclopride binding in rat striatum, quantified using PETQ57089247
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Synthesis, in vivo biodistribution and dosimetry of [11C]N-methylpiperidyl benzilate ([11C]NMPB), a muscarinic acetylcholine receptor antagonistQ72203819
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On neurodegenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesisQ33421837
A comparative evaluation of the dopamine D(2/3) agonist radiotracer [11C](-)-N-propyl-norapomorphine and antagonist [11C]raclopride to measure amphetamine-induced dopamine release in the human striatumQ33861946
AF150(S) and AF267B: M1 muscarinic agonists as innovative therapies for Alzheimer's diseaseQ34147757
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Evidence for sigma opioid receptor: binding of [3H]SKF-10047 to etorphine-inaccessible sites in guinea-pig brainQ34253793
PET study of the M1-agonists [11C]xanomeline and [11C]butylthio-TZTP in monkey and man.Q34400131
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Molecular Mechanisms of Bone 18F-NaF DepositionQ35203602
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Identification of the primary muscarinic autoreceptor subtype in rat striatum as m2 through a correlation of in vivo microdialysis and in vitro receptor binding data.Q36700008
Cholinergic modulation of amyloid precursor protein processing with emphasis on M1 muscarinic receptor: perspectives and challenges in treatment of Alzheimer's diseaseQ37961834
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5-HT2 receptor blockade by ICI 169,369 and other 5-HT2 antagonists modulates the effects of D-2 dopamine receptor blockadeQ41197529
Distinct kinetic binding properties of N-[3H]-methylscopolamine afford differential labeling and localization of M1, M2, and M3 muscarinic receptor subtypes in primate brainQ41538057
Reproducible Analysis of Rat Brain PET Studies Using an Additional [(18)F]NaF Scan and an MR-Based ROI TemplateQ42183322
Reconstitution of agonist-stimulated phosphatidylinositol 4,5-bisphosphate hydrolysis using purified m1 muscarinic receptor, Gq/11, and phospholipase C-beta 1Q43508385
Reduction of cerebrospinal fluid amyloid beta after systemic administration of M1 muscarinic agonistsQ43651491
In vivo visualization of central muscarinic receptors using [11C]quinuclidinyl benzilate and positron emission tomography in baboonsQ43962571
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Dysregulated hippocampal acetylcholine neurotransmission and impaired cognition in M2, M4 and M2/M4 muscarinic receptor knockout miceQ44521481
Synthesis and biological evaluation of the binding of dopamine D2/D3 receptor agonist, (R,S)-5-hydroxy-2-(N-propyl-N-(5'-(18)F-fluoropentyl)aminotetralin ((18)F-5-OH-FPPAT) in rodents and nonhuman primatesQ44803575
M1 muscarinic antagonists interact with sigma recognition sitesQ44918686
Binding characteristics of high-affinity dopamine D2/D3 receptor agonists, 11C-PPHT and 11C-ZYY-339 in rodents and imaging in non-human primates by PET.Q45047807
Positron-labeled dopamine agonists for probing the high affinity states of dopamine subtype 2 receptorsQ45228605
Quantitative analysis of binding parameters of [3H]N-methylscopolamine in central nervous system of muscarinic acetylcholine receptor knockout miceQ45231582
Accuracy of 3-dimensional reconstruction algorithms for the high-resolution research tomographQ46192833
A preliminary PET evaluation of the new dopamine D2 receptor agonist [11C]MNPA in cynomolgus monkeyQ46476544
Radiosynthesis and evaluation of [11C]-(+)-4-propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol as a potential radiotracer for in vivo imaging of the dopamine D2 high-affinity state with positron emission tomography.Q46534517
In vivo quantitative autoradiographic analysis of brain muscarinic receptor occupancy by antimuscarinic agents for overactive bladder treatmentQ46713725
Effect of amphetamine on dopamine D2 receptor binding in nonhuman primate brain: a comparison of the agonist radioligand [11C]MNPA and antagonist [11C]racloprideQ46896544
Performance evaluation of the ECAT HRRT: an LSO-LYSO double layer high resolution, high sensitivity scannerQ48272311
Autoradiographic localization of M1 and M2 muscarine receptors in the rat brainQ48291672
Imaging opiate receptors in the human brain by positron tomographyQ48518140
P433issue1
P304page(s)19
P577publication date2013-03-21
P1433published inEJNMMI ResearchQ27723773
P1476title[11C]AF150(S), an agonist PET ligand for M1 muscarinic acetylcholine receptors
P478volume3

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cites work (P2860)
Q26865012Application of cross-species PET imaging to assess neurotransmitter release in brain
Q38788038Cholinergic System and Post-translational Modifications: An Insight on the Role in Alzheimer's Disease
Q93204051Hunting for the high-affinity state of G-protein-coupled receptors with agonist tracers: Theoretical and practical considerations for positron emission tomography imaging
Q52593214In vitro pharmacological characterization and in vivo validation of LSN3172176 a novel M1 selective muscarinic receptor agonist tracer molecule for positron emission tomography (PET).
Q61455308Less Exploited GPCRs in Precision Medicine: Targets for Molecular Imaging and Theranostics
Q48176913News and views on in-vivo imaging of neurotransmission using PET and MRI.
Q38531787Optimising PET approaches to measuring 5-HT release in human brain
Q42354388[11C]phenytoin revisited: synthesis by [11C]CO carbonylation and first evaluation as a P-gp tracer in rats

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