Effects of Fostamatinib on the Pharmacokinetics of the CYP2C8 Substrate Pioglitazone: Results From In Vitro and Phase 1 Clinical Studies.

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Effects of Fostamatinib on the Pharmacokinetics of the CYP2C8 Substrate Pioglitazone: Results From In Vitro and Phase 1 Clinical Studies. is …
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scholarly articleQ13442814

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P356DOI10.1002/CPDD.243
P8608Fatcat IDrelease_lhlcajge5rdx3hscrw2gg7b5cy
P698PubMed publication ID27163495

P50authorDavid MillsonQ63378747
P2093author name stringPaul Martin
David Lau
Clive Brealey
Michael Gillen
Stuart Oliver
Dominic Surry
Philip Leese
David Sweeny
P2860cites workTreatment of rheumatoid arthritis with a Syk kinase inhibitor: a twelve-week, randomized, placebo-controlled trialQ46271720
Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics of pioglitazoneQ46496013
Fostamatinib, a Syk-kinase inhibitor, does not affect methotrexate pharmacokinetics in patients with rheumatoid arthritisQ48933623
Pioglitazone is metabolised by CYP2C8 and CYP3A4 in vitro: potential for interactions with CYP2C8 inhibitorsQ79984892
Fostamatinib Disodium.Q33405080
Safety and tolerability of pioglitazone in high-risk patients with type 2 diabetes: an overview of data from PROactiveQ33425406
Baseline comorbidities in a population-based cohort of rheumatoid arthritis patients receiving biological therapy: data from the Australian rheumatology association databaseQ33529391
Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytesQ34184221
Epidemiology and genetics of rheumatoid arthritisQ34731244
Cardiovascular co-morbidity in rheumatic diseasesQ36835851
New era in drug interaction evaluation: US Food and Drug Administration update on CYP enzymes, transporters, and the guidance processQ37124261
Cardiovascular risk in rheumatoid arthritisQ37459157
Efficacy and tolerability of pioglitazone in patients with type 2 diabetes mellitus: comparison with other oral antihyperglycaemic agents.Q37794960
Metabolism of fostamatinib, the oral methylene phosphate prodrug of the spleen tyrosine kinase inhibitor R406 in humans: contribution of hepatic and gut bacterial processes to the overall biotransformationQ43108099
An oral Syk kinase inhibitor in the treatment of rheumatoid arthritis: a three-month randomized, placebo-controlled, phase II study in patients with active rheumatoid arthritis that did not respond to biologic agentsQ46066669
P433issue3
P921main subjectpharmacokineticsQ323936
P304page(s)170-179
P577publication date2016-03-23
P1433published inClinical pharmacology in drug developmentQ27726600
P1476titleEffects of Fostamatinib on the Pharmacokinetics of the CYP2C8 Substrate Pioglitazone: Results From In Vitro and Phase 1 Clinical Studies
P478volume5

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cites work (P2860)
Q54977025Fostamatinib: First Global Approval.
Q92940962New Small Molecule Drugs for Thrombocytopenia: Chemical, Pharmacological, and Therapeutic Use Considerations

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