Activation of PERK kinase in neural cells by proteasome inhibitor treatment

scientific article published on 24 October 2009

Activation of PERK kinase in neural cells by proteasome inhibitor treatment is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/J.1471-4159.2009.06448.X
P932PMC publication ID2882876
P698PubMed publication ID19860852
P5875ResearchGate publication ID38040088

P2093author name stringYing Liu
Le Zhang
Jeffrey N Keller
Annadora J Bruce-Keller
Kalavathi Dasuri
Philip J Ebenezer
Sun Ok Fernandez-Kim
P2860cites workRoles of CHOP/GADD153 in endoplasmic reticulum stressQ24302185
Perk is essential for translational regulation and cell survival during the unfolded protein responseQ28140062
Translational control is required for the unfolded protein response and in vivo glucose homeostasisQ28204066
Regulated translation initiation controls stress-induced gene expression in mammalian cellsQ28506388
Reduced eIF2alpha phosphorylation and increased proapoptotic proteins in agingQ28570097
PERK and GCN2 contribute to eIF2alpha phosphorylation and cell cycle arrest after activation of the unfolded protein response pathwayQ28592902
Protein degradation and protection against misfolded or damaged proteinsQ29618400
MAPK cascade signalling and synaptic plasticityQ29619955
Aging impairs the unfolded protein response to sleep deprivation and leads to proapoptotic signalingQ30496197
Proteasome inhibition modulates kinase activation in neural cells: relevance to ubiquitination, ribosomes, and survivalQ33871372
Protein turnover by the proteasome in aging and disease.Q33959350
Ubiquitin-mediated proteolysis in learning and memoryQ34019149
Development of the proteasome inhibitor Velcade (Bortezomib).Q34327233
The proteasome in brain agingQ34662304
Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease.Q44251931
Cyclin-dependent kinase activity is required for apoptotic death but not inclusion formation in cortical neurons after proteasomal inhibition.Q44323443
Proteasomal inhibition causes the formation of protein aggregates containing a wide range of proteins, including nitrated proteinsQ44518991
Lack of p53 delays apoptosis, but increases ubiquitinated inclusions, in proteasomal inhibitor-treated cultured cortical neuronsQ44627817
Generalized brain and skin proteasome inhibition in Huntington's diseaseQ45045405
Proteasome inhibition by lactacystin in primary neuronal cells induces both potentially neuroprotective and pro-apoptotic transcriptional responses: a microarray analysisQ46578554
Oxidized low-density lipoprotein induces neuronal death: implications for calcium, reactive oxygen species, and caspasesQ48198061
Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis.Q48679489
The unfolded protein response is activated in Alzheimer's disease.Q48839954
p38 mitogen-activated protein kinase is required for central nervous system myelination.Q50923980
Oxidative inactivation of the proteasome in Alzheimer's disease.Q53386725
Gene expression analysis of B-lymphoma cells resistant and sensitive to bortezomib*Q58214451
Proteasome inhibition induces reversible impairments in protein synthesis.Q64998535
Impaired proteasome function in Alzheimer's diseaseQ73897101
Overexpression of proteasome beta5 assembled subunit increases the amount of proteasome and confers ameliorated response to oxidative stress and higher survival ratesQ81300121
Endoplasmic reticulum stress features are prominent in Alzheimer disease but not in prion diseases in vivoQ83323941
Hypothesis: proteasomal dysfunction: a primary event in neurogeneration that leads to nitrative and oxidative stress and subsequent cell deathQ34699662
HIV-1 protease inhibitors nelfinavir and atazanavir induce malignant glioma death by triggering endoplasmic reticulum stress.Q34714150
The role of mitogen-activated protein kinase pathways in Alzheimer's diseaseQ35059550
Translational regulation in the cellular response to biosynthetic load on the endoplasmic reticulum.Q35133775
Does proteasome inhibition play a role in mediating neuropathology and neuron death in Alzheimer's disease?Q35191073
Analysis of nucleolar protein dynamics reveals the nuclear degradation of ribosomal proteinsQ35830128
Proteolytic dysfunction in neurodegenerative disordersQ35941669
Endoplasmic reticulum dysfunction in brain pathology: critical role of protein synthesisQ36268426
Role of the unfolded protein response in cell deathQ36351719
Proteasome regulation of oxidative stress in aging and age-related diseases of the CNS.Q36399788
Ubiquitin-proteasome system and Parkinson's diseaseQ36593351
Ubiquitin proteasome system as a pharmacological target in neurodegeneration.Q36607342
Interplay between protein synthesis and degradation in the CNS: physiological and pathological implicationsQ36663735
Expanding insights on the involvement of endoplasmic reticulum stress in Parkinson's diseaseQ36804706
The pathways to tumor suppression via route p38.Q36877196
p38alpha: a suppressor of cell proliferation and tumorigenesisQ36980265
p38 Mitogen-activated protein kinase regulates myelinationQ36997755
PERK and PKR: old kinases learn new tricksQ37140418
The unfolded protein response is activated in pretangle neurons in Alzheimer's disease hippocampusQ37164517
Think locally: control of ubiquitin-dependent protein degradation in neuronsQ37349687
Non-classical p38 map kinase functions: cell cycle checkpoints and survivalQ37374255
Transducing neuronal activity into dendritic spine morphology: new roles for p38 MAP kinase and N-cadherinQ37393562
Proteasome inhibition potentiates antitumor effects of photodynamic therapy in mice through induction of endoplasmic reticulum stress and unfolded protein responseQ37448609
c-Jun N-terminal kinase mediates lactacystin-induced dopamine neuron degenerationQ39938608
Amyloid peptides in different assembly states and related effects on isolated and cellular proteasomesQ39993629
Proteasome inhibitor PS-341 induces apoptosis through induction of endoplasmic reticulum stress-reactive oxygen species in head and neck squamous cell carcinoma cells.Q40291997
Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cellsQ40310345
Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cellsQ40339637
P38 activation mediates amyloid-beta cytotoxicityQ40368411
Proteasome inhibition alters glucose-stimulated (pro)insulin secretion and turnover in pancreatic {beta}-cells.Q40459805
Proteasome inhibition alters neural mitochondrial homeostasis and mitochondria turnoverQ40595923
Central role of the proteasome in senescence and survival of human fibroblasts: induction of a senescence-like phenotype upon its inhibition and resistance to stress upon its activation.Q40649321
Oxidized lipoproteins increase reactive oxygen species formation in microglia and astrocyte cell linesQ40951390
Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction.Q41067625
Cellular environment facilitates protein accumulation in aged rat hippocampus.Q42480086
Phosphorylation of eIF2 directs ATF5 translational control in response to diverse stress conditionsQ42523594
Proteasomal inhibition leads to formation of ubiquitin/alpha-synuclein-immunoreactive inclusions in PC12 cellsQ43718632
Age-specific changes in expression, activity, and activation of the c-Jun NH(2)-terminal kinase and p38 mitogen-activated protein kinases by methyl methanesulfonate in ratsQ43737676
Inhibition of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complexQ43947832
Apoptotic changes in the aged brain are triggered by interleukin-1beta-induced activation of p38 and reversed by treatment with eicosapentaenoic acidQ44045957
P433issue1
P407language of work or nameEnglishQ1860
P1104number of pages8
P304page(s)238-245
P577publication date2009-10-24
P1433published inJournal of NeurochemistryQ6295643
P1476titleActivation of PERK kinase in neural cells by proteasome inhibitor treatment
P478volume112

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cites work (P2860)
Q35743868Aging is associated with hypoxia and oxidative stress in adipose tissue: implications for adipose function.
Q39377253Recent insights on principles of synaptic protein degradation
Q42146983The effects of proteasomal inhibition on synaptic proteostasis
Q26825627The roles of protein expression in synaptic plasticity and memory consolidation
Q93205353The switch-like expression of Heme-regulated kinase 1 mediates neuronal proteostasis following proteasome inhibition
Q36224582p38 MAP kinase-dependent phosphorylation of the Gp78 E3 ubiquitin ligase controls ER-mitochondria association and mitochondria motility

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